Characterization of herbal medicine with different particle sizes using pyrolysis GC/MS, SEM, and thermal techniques

Correia, Lidiane Pinto; Procópio, José Valdilânio Virgulino; Santana, Cleildo P.; Santos, Ana Flávia Oliveira; Cavalcante, Horacinna Maria de Medeiros; Macêdo, Rui Oliveira

doi:10.1007/s10973-011-2129-x

Cited by 24 publications

(11 citation statements)

References 12 publications

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“…For drugs derived from the fruit, the greatest mass loss in oxidative atmosphere occurred in sample F3 between the temperature ranges of 184°C to 267°C, with 9.3% mass loss occurring when subjected to similar values in an inert atmosphere. It is suggested that in the decomposition there was no degradation of matrix components of the plant, only output samples of the constituents; there may have been a phase transition, such as volatilization, since similar profiles were obtained for vegetable drugs studied in two atmospheres [ 22 ].…”

Section: Resultsmentioning

confidence: 99%

Model Analytical Development for Physical, Chemical, and Biological Characterization ofMomordica charantiaVegetable Drug

Brandão

Guimarães

Santos³

et al. 2016

Journal of Analytical Methods in Chemistry

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Momordica charantia is a species cultivated throughout the world and widely used in folk medicine, and its medicinal benefits are well documented, especially its pharmacological properties, including antimicrobial activities. Analytical methods have been used to aid in the characterization of compounds derived from plant drug extracts and their products. This paper developed a methodological model to evaluate the integrity of the vegetable drug M. charantia in different particle sizes, using different analytical methods. M. charantia was collected in the semiarid region of Paraíba, Brazil. The herbal medicine raw material derived from the leaves and fruits in different particle sizes was analyzed using thermoanalytical techniques as thermogravimetry (TG) and differential thermal analysis (DTA), pyrolysis coupled to gas chromatography/mass spectrometry (PYR-GC/MS), and nuclear magnetic resonance (1H NMR), in addition to the determination of antimicrobial activity. The different particle surface area among the samples was differentiated by the techniques. DTA and TG were used for assessing thermal and kinetic parameters and PYR-GC/MS was used for degradation products chromatographic identification through the pyrograms. The infusions obtained from the fruit and leaves of Momordica charantia presented antimicrobial activity.

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Section: Resultsmentioning

confidence: 99%

Model Analytical Development for Physical, Chemical, and Biological Characterization ofMomordica charantiaVegetable Drug

Brandão

Guimarães

Santos³

et al. 2016

Journal of Analytical Methods in Chemistry

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“…Peak regions at <2000 cm −1 represent the carbonyl group compounds and the =C bonds in the aromatic rings and aromatic CH bonds on substituted rings [46]. The peaks in the region <1500 cm −1 are related to carbon-oxygen bonds (CO) in ethers, esters, and carboxylic acids and are indicative of a wide variety of metabolites, such as tannins, flavonoids, and anthraquinones [47]. FTIR analysis suggested the formation of hydrogen bonding between the secondary compounds of AGN and the hydroxyl group of the HPMC.…”

Section: Thermal Analysis Of the Agnc Formulation By Dsc And Ft-irmentioning

confidence: 99%

Bio- Fortification of Angelica gigas Nakai Nano-Powder Using Bio-Polymer by Hot Melt Extrusion to Enhance the Bioaccessibility and Functionality of Nutraceutical Compounds

et al. 2019

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Angelica gigas Nakai (AGN) is a popular traditional herbal medicine which has been used to alleviate various human diseases in Korea since ancient times. However, the low bioaccessibility of the nutraceutical compounds of AGN results in a poor water solubility, thereby limiting bioavailability. In this regard, a ternary AGN–biopolymer–plasticizer composite (AGNC) was developed to enhance the bioaccessibility of nutraceutical compounds from extrudate AGN formulations manufactured by hot melt extrusion (HME). The AGNC was prepared with extrudate AGN (EAGN) using different hydroxypropyl methylcellulose (HPMC) biopolymers (5% w/w) viz.: hypromellose phthalate (HP), hypromellose (AN), and hypromellose (CN) along with acetic acid (AA) (0.1 M, 20% w/v) as a plasticizer. The non-extrudate fresh AGN (FAGN) powder was used as a control. The physicochemical properties of the extrudate formulations and control were characterized by differential scanning calorimetry (DSC) and Fourier-transform infrared spectroscopy (FTIR). DSC analysis showed a lower enthalpy (ΔH) (12.22 J/g) and lower glass transition temperature (Tg) (41 °C) in HP-AA-EAGN compared to the control. FTIR confirmed the physical crosslinking between AGN and biopolymer in the extrudate composite and demonstrated that some functional groups formed viz., -OH and -CH2. The obtained result also shows that the particle size was reduced by 341 nm, and solubility was increased by 65.5% in HP-AA-EAGN compared to the control (1499 nm, 29.4%, respectively). The bioaccessibility of the total phenolic content and the total flavonoids—including decursin (D) and decursinol angelate (DA)—were significantly higher in HP-AA-EAGN compared to the control. The 2,2-diphenyl-1 picryl hydrazyl (DPPH) free radical scavenging capacity and ferric reducing antioxidant power assay (FRAP) indicated that the HP-AA-EAGN formulation preserves a greater antioxidant profile than the other formulations. Finally, it is summarized that the addition of acidified HP biopolymer increased the bioaccessibility, functionality, and improved the physicochemical properties of nutraceutical compounds in the extrudate AGN formulation.

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“…SEM enabled us to detect the existence of divergences from the expected results, allowing a better quality evaluation of the herbal medicine powder production technology [19].…”

Section: Granulometrymentioning

confidence: 99%

“…Recent study showed through TG and others techniques that herbal medicine particle size powder samples demonstrate differences in its analytical signal, showing that samples in different granulometries could have different physical and chemical qualities [19].…”

Section: Thermogravimetric Characterization Of Herbal Medicinementioning

confidence: 99%

“…The presented model is still being developed with the goal of being used to sort through thermogravimetry the different particle sizes, which will be interesting, considering that previous studies [19] demonstrated the influence of the herbal medicine powder particle size in the physical, chemical, pharmacological and toxicological effects.…”

Section: Determination Of the Reaction Order And Activation Energymentioning

confidence: 99%

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Herbal medicine physical quality evaluation by thermal analysis using adapted Ozawa method

Correia

Procópio

Santana

et al. 2015

J Therm Anal Calorim

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The aim of this study was to evaluate the physical quality of Tabebuia caraiba (Mart.) Bur. powder, separately in three batches of different particle sizes, through the adapted Ozawa method. The Ozawa model was used for thermogravimetry (TG) data analysis in dynamic synthetic air and nitrogen atmospheres in different heating rates (5, 10, 20 and 40°C min -1 ). The software TA-50 was used to data treatment. Kinetic data showed different values of activation energy and same reaction order according to the particle powder sample size in a specific model (derivative or tangent) of data treatment. The difference factor (F 1 ) was used to compare the parallelism line of the samples constructed by Ozawa graphs. Different kinetic results discriminate the particles size of the samples. TG technique allowed discriminating different particle sizes of herbal medicine powder.

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Characterization of herbal medicine with different particle sizes using pyrolysis GC/MS, SEM, and thermal techniques

Cited by 24 publications

References 12 publications

Model Analytical Development for Physical, Chemical, and Biological Characterization ofMomordica charantiaVegetable Drug

Model Analytical Development for Physical, Chemical, and Biological Characterization ofMomordica charantiaVegetable Drug

Bio- Fortification of Angelica gigas Nakai Nano-Powder Using Bio-Polymer by Hot Melt Extrusion to Enhance the Bioaccessibility and Functionality of Nutraceutical Compounds

Herbal medicine physical quality evaluation by thermal analysis using adapted Ozawa method

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