Characterization of gut microbiota composition in HIV-infected patients with metabolic syndrome

Villanueva-Millán, María Jesús; Pérez-Matute, Patricia; Recio-Fernández, Emma; Rosales, Jose Miguel Lezana; Oteo, José A.

doi:10.1007/s13105-019-00673-9

Cited by 15 publications

(18 citation statements)

References 52 publications

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“…Gelpi et al (2020) describe the following conditions in these patients: a lower microbial diversity, increased abundance of Gammaproteobacteria and Desulfovibionaceae , and a decrease of several Clostridia ( Butyrivibrio, Coprococcus‐2, Lachnospiraceae UCG‐001 and CAG‐56 ), which was associated with a twofold increase in the risk of MetS (Gelpi et al, 2020). Moreover, Villanueva‐Millán et al (2019) found a reduction in butyrate‐producing bacteria with an anti‐inflammatory role: Eubacterium eligens, Retortamonas intestinalis, Roseburia inulinivorans and Subdoligranulum sp. and Faecalibacterium prausnitzii (Villanueva‐Millán et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

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Gut microbiota from Mexican patients with metabolic syndrome and HIV infection: An inflammatory profile

Amador-Lara

Andrade-Villanueva

Vega-Magaña

et al. 2022

Journal of Applied Microbiology

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Aim A remarkable increase in metabolic syndrome (MetS) has occurred in HIV‐infected subjects. Gut dysbiosis is involved in the pathogenesis of metabolic disorders. Therefore, the aim is to explore the profile of the gut microbiota in Mexican population with HIV infection and MetS. Methods and Results In all, 30 HIV‐infected patients with MetS were compared to a group of 30 patients without MetS, treated with integrase inhibitors and undetectable viral load were included in the study. Stool samples were analysed by 16S rRNA next‐generation sequencing. High‐sensitivity C‐reactive protein >3 mg L−1 and higher scores in cardiometabolic indices were associated with MetS. The group with MetS was characterized by a decrease in α‐diversity, higher abundance of Enterobacteriaceae and Prevotella, as well as a dramatic decrease in bacteria producing short‐chain fatty acids. Prevotella negatively correlated with Akkermansia, Lactobacillus and Anaerostipes. Interestingly, the group without MetS presented higher abundance of Faecalibacterium, Ruminococcus, Anaerofilum, Oscillospira and Anaerostipes. Functional pathways related to energy metabolism and inflammation were increased in the group with MetS. Conclusions HIV‐infected patients with MetS present a strong inflammatory microbiota profile; therefore, future strategies to balance intestinal dysbiosis should be implemented.

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Section: Introductionmentioning

confidence: 99%

“…Moreover, Villanueva‐Millán et al (2019) found a reduction in butyrate‐producing bacteria with an anti‐inflammatory role: Eubacterium eligens, Retortamonas intestinalis, Roseburia inulinivorans and Subdoligranulum sp. and Faecalibacterium prausnitzii (Villanueva‐Millán et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Gut microbiota from Mexican patients with metabolic syndrome and HIV infection: An inflammatory profile

Amador-Lara

Andrade-Villanueva

Vega-Magaña

et al. 2022

Journal of Applied Microbiology

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“…Restriction and adjustment were used most frequently, although n = 7 studies used no apparent method to control confounders. Nearly half (n = 32) of studies excluded participants who had recently taken antibiotics/antimicrobials ( 106,112,113,120,123,126,131,[134][135][136]. Such studies typically excluded patients with major chronic diseases or cardiometabolic phenotypes (such as major cardiovascular disease) other than that being studied.…”

Section: Number Of Articlesmentioning

confidence: 99%

“…Several studies utilized data from the TwinsUK cohort (9,46,63,75) recruited through media campaigns (88) and the American Gut project (8), in which participants were recruited online (85). Another 22 relied on in-or out-patient clinical samples (1,3,14,18,33,38,47,58,62,65,71,73,74,89,90,101,103,119,122,123,126,131). Volunteer and convenience samples are known to be self-selected on both high SES and good health, with potentially serious implications for inference (37).…”

Section: Sample Selectionmentioning

confidence: 99%

“…Many studies restrict eligibility to otherwise healthy individuals, illustrated in Figure 3d, where H 1 represents health at baseline and S represents selection into the study. The rationale may be that health status can impact the microbiome and the disease of interest and is thus a confounder (59,126). However, H 1 could be affected by both prevalent metabolic syndrome (Y 0 ) and previous microbiome (M 0 ), so H 1 is termed a collider, meaning a common effect of exposure and outcome (54,99).…”

Section: Study Design and Selection Biasmentioning

confidence: 99%

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Sick Individuals and Sick (Microbial) Populations: Challenges in Epidemiology and the Microbiome

Renson

Herd

Dowd

2020

Annu. Rev. Public Health

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The human microbiome represents a new frontier in understanding the biology of human health. While epidemiology in this area is still in its infancy, its scope will likely expand dramatically over the coming years. To rise to the challenge, we argue that epidemiology should capitalize on its population perspective as a critical complement to molecular microbiome research, allowing for the illumination of contextual mechanisms that may vary more across populations rather than among individuals. We first briefly review current research on social context and the gut microbiome, focusing specifically on socioeconomic status (SES) and race/ethnicity. Next, we reflect on the current state of microbiome epidemiology through the lens of one specific area, the association of the gut microbiome and metabolic disorders. We identify key methodological shortcomings of current epidemiological research in this area, including extensive selection bias, the use of noncompositionally robust measures, and a lack of attention to social factors as confounders or effect modifiers.

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The Gut Microbiome, Microbial Metabolites, and Cardiovascular Disease in People Living with HIV

et al. 2023

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Characterization of gut microbiota composition in HIV-infected patients with metabolic syndrome

Cited by 15 publications

References 52 publications

Gut microbiota from Mexican patients with metabolic syndrome and HIV infection: An inflammatory profile

Gut microbiota from Mexican patients with metabolic syndrome and HIV infection: An inflammatory profile

Sick Individuals and Sick (Microbial) Populations: Challenges in Epidemiology and the Microbiome

The Gut Microbiome, Microbial Metabolites, and Cardiovascular Disease in People Living with HIV

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