Characterization of glucagon-like peptide 1 receptor (GLP1R) gene in chickens: functional analysis, tissue distribution, and identification of its transcript variants

Huang, Guodong; Li, J.; Fu, Hao; Yan, Zhong; Bu, Guixian; He, Xiaping; Wang, Y.

doi:10.1016/j.domaniend.2012.01.005

Cited by 22 publications

(19 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, Mo et al (2014) demonstrated that chicken GLP-2 receptor expressed in CHO cells could be potently activated by chicken GLP-2 but not by other structurally related peptides, including chicken GLP-1 and glucagon, suggesting that GLP-2 receptor is a functional receptor specific to GLP-2 in chicken as well as in mammals. In contrast, chicken GLP-1 receptor expressed in Chinese hamster ovary (CHO) cells could not be activated by GLP-2 (Huang et al, 2012). These findings suggest that GLP-2 express their functions via its own receptor.…”

Section: Al 2003)mentioning

confidence: 93%

Glucagon-like Peptide-2 Functions as an Anorexigenic Peptide not only in the Central Nervous System but also in the Peripheral Circulation in Broiler Chicks

et al. 2015

View full text Add to dashboard Cite

Brain-gut peptides play important roles in the appetite regulatory system in mammals. Glucagon-like peptide (GLP)-1, GLP-2, and oxyntomodulin (OXM) are processed from the same precursor, proglucagon, in both brain and intestines in mammals and birds. We previously showed that intracerebroventricular administration of these three peptides significantly suppressed food intake in chicks. However, peripheral roles of chicken GLP-2 have not yet been investigated, although GLP-2 plays important roles both in central and peripheral regulation of food intake in mammals. The aim of this study is to investigate whether GLP-2 functions as an anorexigenic peptide in both brain and peripheral circulation in chicks. Intracerebroventricular administration of GLP-2 significantly suppressed food intake in chicks. Twenty-four hours of fasting significantly decreased the mRNA level of proglucagon in the medulla oblongata of chicks. These results suggest that GLP-2 functions as anorexigenic peptides in the central nervous system in chicks. In addition, intravenous administration of GLP-2 significantly suppressed food intake in chicks. Lines of evidence suggest that dietary nutrients stimulate the secretion of GLP-2 from L cells in the small intestine in chickens. These findings suggest that GLP-2 functions as both central and peripheral anorexigenic signals in chicks.

show abstract

Section: Al 2003)mentioning

confidence: 93%

Glucagon-like Peptide-2 Functions as an Anorexigenic Peptide not only in the Central Nervous System but also in the Peripheral Circulation in Broiler Chicks

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Chicken GLP1R was highly expressed in the telencephalon, midbrain, hindbrain and hypothalamus (Huang et al . 2012). All these findings suggest that GLP‐1 functions as an anorexigenic peptide in the central nervous system in chicks.…”

Section: Introductionmentioning

confidence: 99%

“…Chicken GLP‐1 receptor expressed in Chinese hamster ovary cells was potently activated by GLP‐1 but not by glucagon and GLP‐2 (Huang et al . 2012). Recently, Mo et al .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Glucagon‐related peptides and the regulation of food intake in chickens

Honda

2016

Animal Science Journal

View full text Add to dashboard Cite

The regulatory mechanisms underlying food intake in chickens have been a focus of research in recent decades to improve production efficiency when raising chickens. Lines of evidence have revealed that a number of brain‐gut peptides function as a neurotransmitter or peripheral satiety hormone in the regulation of food intake both in mammals and chickens. Glucagon, a 29 amino acid peptide hormone, has long been known to play important roles in maintaining glucose homeostasis in mammals and birds. However, the glucagon gene encodes various peptides that are produced by tissue‐specific proglucagon processing: glucagon is produced in the pancreas, whereas oxyntomodulin (OXM), glucagon‐like peptide (GLP)‐1 and GLP‐2 are produced in the intestine and brain. Better understanding of the roles of these peptides in the regulation of energy homeostasis has led to various physiological roles being proposed in mammals. For example, GLP‐1 functions as an anorexigenic neurotransmitter in the brain and as a postprandial satiety hormone in the peripheral circulation. There is evidence that OXM and GLP‐2 also induce anorexia in mammals. Therefore, it is possible that the brain‐gut peptides OXM, GLP‐1 and GLP‐2 play physiological roles in the regulation of food intake in chickens. More recently, a novel GLP and its specific receptor were identified in the chicken brain. This review summarizes current knowledge about the role of glucagon‐related peptides in the regulation of food intake in chickens.

show abstract

“…First, tissue-specific alternate transcripts/ splice variants may not be detected by using a single set of primers. Second, smaller or bigger PCR products than anticipated may be detected and would need sequencing in order to estimate relevance (14). Of importance, the above issues are exemplified by two studies, one using chicken GLP1R and the other rat GLP1R, which show that tissue-specific variants of GLP1R do exist and these may explain the extrapancreatic actions of GLP-1/-2 (15).…”

mentioning

confidence: 99%

Tissue-Specific Expression of GLP1R in Mice: Is the Problem of Antibody Nonspecificity Solved?

Aroor

Nistala

2014

Diabetes

View full text Add to dashboard Cite

Characterization of glucagon-like peptide 1 receptor (GLP1R) gene in chickens: functional analysis, tissue distribution, and identification of its transcript variants

Cited by 22 publications

References 45 publications

Glucagon-like Peptide-2 Functions as an Anorexigenic Peptide not only in the Central Nervous System but also in the Peripheral Circulation in Broiler Chicks

Glucagon-like Peptide-2 Functions as an Anorexigenic Peptide not only in the Central Nervous System but also in the Peripheral Circulation in Broiler Chicks

Glucagon‐related peptides and the regulation of food intake in chickens

Tissue-Specific Expression of GLP1R in Mice: Is the Problem of Antibody Nonspecificity Solved?

Contact Info

Product

Resources

About