Characterization of Firmiana colorata (Roxb.) R. Br. leaf extract and its silver nanoparticles reveal their antioxidative, anti-microbial, and anti-inflammatory properties

Abstract

Nanotechnology is the integrative science in the field of physics, chemistry and biology. For the synthesis of silver nanoparticles, a simple approach was applied using Firmiana colorata (Roxb.) aqueous leaf extract. During the synthesis of this silver nanoparticle, the solution color changes from green to deep brown due to the reduction of silver. The phytocompounds present in the Firmiana colorata (Roxb.) leaf extract acts as a reducing as well as a capping agent. Identifying the presence of bioactive compounds responsible for the reduction of silver was extensively characterized by UV–Vis spectrophotometer, FTIR, SEM, and EDX. Moreover, to know the efficacy of the silver nanoparticles (AgNps) antioxidant and antimicrobial studies were evaluated against the human pathogenic bacteria. Furthermore, GC–MS analysis of the leaf extract of Firmiana colorata has been done followed by the in-silico molecular docking against the Anti-inflammatory and oxidative protein. Here within this study, a comparative evaluation was done among the Firmiana colorata (Roxb.) leaf extract and the synthesized silver nanoparticles. Results indicate that ethnomedicinally lesser known Firmiana colorata (Roxb.) and AgNps have the potency to act as anti-inflammatory, antioxidative, and antimicrobial agents.

Biosynthesis and Characterization of Silver Nanoparticles Using Tribulus terrestris Seeds: Revealed Promising Antidiabetic Potentials

“…AgNPs have been shown to trigger apoptosis and reduce the level of matrix metalloproteinase in wounds, limiting angiogenesis [ 14 ] and vascular permeability with the help of growth factors, i.e., VEGF, interleukin (IL)-1, and advanced glycation in endothelial cells of the retina [ 15 ]. However, the effect of AgNPs on diabetes is an area that has not been extensively studied [ 16 ].…”

Slowly Making Sense: A Review of the Two-Step Venom System within Slow (Nycticebus spp.) and Pygmy Lorises (Xanthonycticebus spp.)

“…Supplementary File S1: detailed list of top 100 NCBI BLAST hits on the two chains from BGEsp from N. javanicus , Supplementary File S2: list of all plants slow lorises have been observed eating as well as potential medicinal/toxic effects that may contribute to the venom system and Supplementary File S3: Proposed research agenda for the slow loris venom system. References [ 64 ] are cited in Supplementary File S1 and references [ 56 , 101 , 137 , 138 , 139 , 166 , 167 , 168 , 169 , 170 , 171 , 172 , 173 , 174 , 175 , 176 , 177 , 178 , 179 , 180 , 181 , 182 , 183 , 184 , 185 , 186 , 187 , 188 , 189 , 190 , 191 , 192 , 193 , 194 , 195 , 196 , 197 , 198 , 199 , 200 , 201 , 202 , 203 , 204 , 205 , 206 , 207 , 208 ,…”