Characterization of endothelium-dependent relaxation and modulation by treatment with pioglitazone in the hypercholesterolemic rabbit renal artery

Pioglitazone reduces tumor necrosis factor-α serum concentration and mRNA expression of adipose tissue in hypercholesterolemic rabbits

“…We found that pioglitazone has no effect on blood glucose levels in hypercholesterolemic rabbits in our study. Consistent with the results reported by Taniguchi et al [25] and Moroe et al [26], we also found that pioglitazone had no effect on serum lipid profile in rabbits fed with cholesterol chow. Administration with pioglitazone for 4 weeks significantly decreased serum TNF-α level in hypercholesterolemic rabbits.…”

Puerarin decreases serum total cholesterol and enhances thoracic aorta endothelial nitric oxide synthase expression in diet-induced hypercholesterolemic rats

“…This observation is in accordance with that of Morore and et al They demonstrated that rabbit fed with high cholesterol did not influence relaxation induced by acetylcholine on renal arteries. It is due to the enhancement effect of hypercholesterolemia on EDHF-mediated relaxation which compensates the impairment of responsiveness to receptordependent stimuli in the initial phase of hypercholesterolemia (Moroe et al, 2004). In addition, change of eNOS expression was observed on the Western Blot data presented in the current study.…”

“…In fact, hypercholesterolemia increases oxygenderived free radical production in the endothelium, which increases NO breakdown (Ohara et al, 1993;Mugge et al, 1994). The enhancement of the EDHF component may serve as a compensatory mechanism to uphold vasorelaxation in the disease states (Moroe et al, 2004). Puerarin restored the reduced eNOS expression in rats fed with HCD and significant decreased the atherogenic index.…”

Evidence-Based Efficacy of Kampo Formulas in a Model of Non Alcoholic Fatty Liver

“…The other 5 groups received 1% KBG (group KBG), 1% OGT (group OGT), 1% SST (group SST), 0.045% vitamin E (group VE), or 300 ppm PG (group PG). Treatment regimens and compounds were chosen based on previous studies from our group (6) and other laboratories (14,15).…”