Nano Based Drug Delivery 2015

DOI: 10.5599/obp.8.4

|View full text |Cite

|

Sign up to set email alerts

|

Characterization of drug-loaded nanoparticles

Irina Kalashnikova¹,

Norah A. Albekairi²,

Sanaalarab Al-Enazy³

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Z-potential1

Drug Release1

Citation Types

Supporting

0

Mentioning

2

Contrasting

0

Year Published

2015

2015

2024

2024

Publication Types

Select...

Article4

Relationship

Self Cite1

Independent3

Authors

Journals

Cited by 4 publications

(2 citation statements)

References 107 publications

(145 reference statements)

Supporting

0

Mentioning

2

Contrasting

0

Order By: Relevance

“…Details regarding the equations relating drug loading and encapsulation efficiency have been published previously [21].…”

Section: Z-potentialmentioning

confidence: 99%

“…Release of digoxin from the nanoparticles was studied under sink conditions in phosphate buffered saline (PBS) at 37°C as described previously [21,22]. In vitro drug release profiles in PBS have been previously shown to correlate well with the kinetics of in vivo therapeutic effects [18].…”

Section: Drug Releasementioning

confidence: 99%

See 1 more Smart Citation

Transport of digoxin-loaded Polymeric Nanoparticles Across BeWo cells, an In Vitro Model of Human Placental Trophoblast

¹

,

²

,

³

et al. 2015

Self Cite

View full text Add to dashboard Cite

Background: Fetal arrhythmias can lead to fetal congestive heart failure and hydrops fetalis. Digoxin (the first-line treatment) has low transplacental permeability and high risk of maternal side effects. Biodegradable digoxin-loaded PEGylated poly(lactic-co-glycolic acid) nanoparticles may increase digoxin transport across BeWo b30 cell monolayers (an in vitro model of trophoblast in human placenta) by reducing the drug's interaction with P-gp. Results/methodology: The nanoparticles showed high encapsulation efficiency and sustained release over 48 h. Transport studies revealed significantly increased permeability across BeWo cell layers of digoxin-loaded nanoparticles when compared with free digoxin. P-gp inhibition also increased the permeability of digoxin, but not digoxin-loaded nanoparticles. Conclusion: This represents a novel treatment strategy for fetal cardiovascular disease which may improve maternal and fetal outcomes.

“…Details regarding the equations relating drug loading and encapsulation efficiency have been published previously [21].…”

Section: Z-potentialmentioning

confidence: 99%

“…Release of digoxin from the nanoparticles was studied under sink conditions in phosphate buffered saline (PBS) at 37°C as described previously [21,22]. In vitro drug release profiles in PBS have been previously shown to correlate well with the kinetics of in vivo therapeutic effects [18].…”

Section: Drug Releasementioning

confidence: 99%

Transport of digoxin-loaded Polymeric Nanoparticles Across BeWo cells, an In Vitro Model of Human Placental Trophoblast

¹

,

²

,

³

et al. 2015

Self Cite

View full text Add to dashboard Cite

Background: Fetal arrhythmias can lead to fetal congestive heart failure and hydrops fetalis. Digoxin (the first-line treatment) has low transplacental permeability and high risk of maternal side effects. Biodegradable digoxin-loaded PEGylated poly(lactic-co-glycolic acid) nanoparticles may increase digoxin transport across BeWo b30 cell monolayers (an in vitro model of trophoblast in human placenta) by reducing the drug's interaction with P-gp. Results/methodology: The nanoparticles showed high encapsulation efficiency and sustained release over 48 h. Transport studies revealed significantly increased permeability across BeWo cell layers of digoxin-loaded nanoparticles when compared with free digoxin. P-gp inhibition also increased the permeability of digoxin, but not digoxin-loaded nanoparticles. Conclusion: This represents a novel treatment strategy for fetal cardiovascular disease which may improve maternal and fetal outcomes.

PEGylated Polymeric Nanoparticles Loaded with 2-Methoxyestradiol for the Treatment of Uterine Leiomyoma in a Patient-Derived Xenograft Mouse Model

¹

,

²

,

³

et al. 2023

Journal of Pharmaceutical Sciences

View full text Add to dashboard Cite

No abstract

Development of tumor-specific liposomes containing quantum dots-photosensitizer conjugate used for radiotherapy

¹

,

²

,

³

et al. 2022

Journal of Liposome Research

View full text Add to dashboard Cite

No abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Product

Browser Extension Assistant by scite Citation Statement Search Reference Check Visualizations Dashboards Explore Journals Explore Organizations Explore Funders Embedding Badge Embedding Citation Search Pricing

Resources

Blog Help & FAQ Accessibility Statement API Terms For Universities & Governments For Researchers For Publishers For Corporate, Pharma & Enterprise Author Marketing Become an Affiliate Get an organization trial or quote scite Data & Services

About

News & Press Careers Read our Paper Coverage

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Copyright © 2024 scite LLC. All rights reserved.

Made with 💙 for researchers

Part of the Research Solutions Family.