Characterization of DNA polymorphisms in three populations of hereford cattle and their associations with growth and maternal EPD in line 1 herefords.

Moody, D. E.; Pomp, Daniel; Newman, Scott; MacNeil, M. D.

doi:10.2527/1996.7481784x

Cited by 70 publications

(61 citation statements)

References 20 publications

(36 reference statements)

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“…Two alleles at each RFLP marker were present in both Canchim and Charolais. Although previous reports indicate the influence of κ-casein and β-lactoglobulin on maternal effects in beef cattle (Moody et al, 1994), no significant variation of allele frequencies was observed over generations of Canchim. A highly significant variation (P < 0.01) was observed for GH AluI polymorphism, with a linear increase of the allele coding for valine (V) at position 127 of this peptide ( Figure 1).…”

Section: Allele Frequency Variationmentioning

confidence: 56%

Selection for breed-specific growth hormone and IGF-I alleles in a synthetic beef cattle cross, Canchim

et al. 1999

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This study was developed to evaluate selection effects on gene frequencies in a synthetic beef cattle cross (5/8 Charolais, 3/ 8 Zebu) named Canchim. A sample of 154 Canchim animals, representing three generation classes, was analyzed for seven molecular markers. Thirty-six Charolais cattle were also studied for comparison. A highly significant variation (P < 0.01), with a linear increase of the allele coding for valine at position 127 of the growth hormone peptide, was observed through generations. This allele was found in the Charolais sample but is not observed in Brazilian Bos indicus breeds. Four alleles were found for a microsatellite in the 5' flanking region of insulin-like growth factor I gene in Canchim. Allele sizes ranged from 231 to 225 bp. There was a significant (P < 0.05) nonlinear increase in the 225-bp allele frequency. This allele was not observed in Charolais. Six alleles were observed for microsatellite CSFM50 in the Canchim population. A significant (P < 0.05) linear reduction of the 168-bp allele was observed over the generations. The hypothesis of preferential mating for growth hormone polymorphism was supported by Wright's F-statistics. Estimated F IS value for growth hormone was 0.59 (P < 0.01). These results suggest that selection influenced three out of seven loci analyzed. The simultaneous increases of a Bos taurus-specific growth hormone allele and a Bos indicus-specific insulin-like growth factor I allele indicate that phenotypic selection favored different regions of both genomes.

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Section: Allele Frequency Variationmentioning

confidence: 56%

Selection for breed-specific growth hormone and IGF-I alleles in a synthetic beef cattle cross, Canchim

et al. 1999

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“…Li et al (2002) detected QTLs for birth weight at 20 to 30 cM and 65 to 75 cM intervals in a Bos taurus breed. An association between IGF-1 and weights was detected by Moody et al (1996) in Hereford cattle and by Pereira (2002) for birth weight and yearling weight in the same Canchim samples investigated here. An association between IGF-1 and growth was reported in swine by Casas-Carrillo et al (1997) and in mice by Horvat and Medrano (1995).…”

Section: Qtl Mappingmentioning

confidence: 90%

“…Marker TEXAN15 is located at 4.2 cM of candidate gene IGF-1 and marker BMS1248 at 15.4 cM. QTLs influencing growth and other traits have been reported in this interval (Moody et al, 1996;Davis et al, 1998;Stone et al, 1999;Pereira, 2002). Deviations in the allelic frequencies of microsatellite TEXAN15 were reported in a Nellore population selected for weight, suggesting its association with a QTL affecting this trait (Merzel et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

“…Bovine chromosome 5 harbors QTLs that influence milk production (Kalm et al, 1998), reproductivon (Kirkpatrick et al, 2000;Kappes et al, 2000;Lien et al, 2000) and growth and carcass traits (Moody et al, 1996;Davis et al, 1998;Stone et al, 1999;Casas et al, , 2002Pereira, 2002;Li et al, 2002). The location of some of these QTLs approaches the position of the IGF-1 (insulin-like growth factor) gene and, since IGF-1 plays a fundamental role in regulation growth and development, this gene is considered a strong candidate for the QTL effect.…”

Section: Introductionmentioning

confidence: 99%

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QTL affecting body weight in a candidate region of cattle chromosome 5

et al. 2003

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The objective of this work was to identify QTLs for liveweight in a candidate region of bovine chromosome 5. Half-sib families from two lines, one traditional and the other new, of Canchim beef cattle (5/8 Charolais + 3/8 Zebu) were genotyped for four microsatellite markers, including the microsatellite in the IGF-1 (insulin-like growth factor-1) promoter region. Significant differences in allele distribution between the two lines were found for three markers. Interval mapping analyses in this region indicated the presence of a QTL controlling birth weight (p < 0.05) and of a QTL influencing breeding value for yearling weight (p < 0.01) in the newer line of the breed. The previously identified interaction between the IGF-1 genotype and genetic group strengthens the hypothesis of a linked QTL rather than an IGF-1 effect on growth traits in the Canchim cattle.

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“…Ge et al (2001) reported an effect of the IGF-I/SnaBI polymorphism, located in the regulatory region of the IGF-I gene, on growth traits in Angus cattle, also suggested a direct action of this polymorphism on gene transcription and, consequently, on phenotypic traits. Moody et al (1996) observed an effect of STR polymorphism on body weight at birth and at weaning, and with the growth rate In Hereford cattle, Siadkowska et al (2006) reported a correlation between the polymorphism in the 5'-non coding region of the IGF-I and meat and milk production traits in Polish HF cattle. Finally for the reason that quantitative traits are regulated by many genes and affected by interactions among them, and thus, a candidate gene associated with a trait in one population may have a different effect, or show no effect at all, in another population due to negative effects of other genes and epistatic interactions of the candidate gene with other genes in the population (Pomp, 1994).…”

Section: Discussionmentioning

confidence: 99%

Association of the polymorphism in the 5’ flanking region of the ovine IGF-I gene with growth traits in the Baluchi sheep

et al. 2010

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The insulin-like growth factor 1 (IGF-I) gene has been described in several studies as a candidate gene for growth traits in farm animals. The present preliminary study attempts to establish associations between growth traits and genetic polymorphisms at the 5' flanking region s IGF-I in the Baluchi sheep. The DNA of 102 sheep of the indigenous Iranian Baluchi breed was evaluated. Polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) analysis of the 5' flanking region (Exon1) of the ovine IGF-I gene revealed three banding patterns (genotypes) named as A/A, A/B and B/B. The evaluation of an association effect between these SSCP patterns with birth weight (BW), weaning weight (WW), and average daily gain from birth to weaning (GBW), weaning to six month (GWS) and from six month to yearling age (GSY) suggest a positive effect of pattern (Genotype) A/B with GBW and weaning weight (WW). Pattern (Genotype) B/B had a superior birth weight when compared to those of individuals with other patterns. Moreover, the A/A pattern (Genotype) appeared favourable for live weight at yearling age. These results confirmed the potential usefulness of this gene in marker-assisted selection programmes for sheep breeding. ________________________________________________________________________________

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Characterization of DNA polymorphisms in three populations of hereford cattle and their associations with growth and maternal EPD in line 1 herefords.

Cited by 70 publications

References 20 publications

Selection for breed-specific growth hormone and IGF-I alleles in a synthetic beef cattle cross, Canchim

Selection for breed-specific growth hormone and IGF-I alleles in a synthetic beef cattle cross, Canchim

QTL affecting body weight in a candidate region of cattle chromosome 5

Association of the polymorphism in the 5’ flanking region of the ovine IGF-I gene with growth traits in the Baluchi sheep

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