Characterization of dendrimers

Kokare, Chandrakant; Khot, Shubham; Gorain, Bapi; Kesharwani, Prashant

doi:10.1016/b978-0-12-821250-9.00006-8

Cited by 5 publications

(1 citation statement)

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“…Between 1970–1990, Buhleier et al and Tomalia et al synthesized dendrimers for the first time. Dendrimers have a precise controlled structure, suitable for surface functionalization with different ligands ( Kokare et al, 2021 ). The word dendrimer is derived from a Greek term dendron which means tree, that is because of their distinctive architecture with a number of branching units.…”

Section: Cd44 Engineered Nanocarriers For Cancer Therapymentioning

confidence: 99%

CD44-Targeted Nanocarrier for Cancer Therapy

et al. 2022

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Cluster of differentiation 44 (CD44) is a cell surface glycoprotein overexpressed in varieties of solid tumors including pancreatic, breast, ovary, brain, and lung cancers. It is a multi-structural glycoprotein of the cell surface which is majorly involved in cell proliferation, cell-to-cell interaction, cellular migration, inflammation, and generation of immune responses. Numerous studies focus on the development of nanocarriers for active targeting of the CD44 receptor to improve efficacy of targeting chemotherapy and achieve precise chemotherapy by defining the release, uptake, and accumulation of therapeutic agents. The CD44 receptor has a selective binding affinity towards hyaluronic and chondroitin sulfate (CS). Taking this into consideration, this review focused on the role of CD44 in cancer and its therapy using several nanocarriers such as polymeric/non-polymeric nanoparticles, dendrimer, micelles, carbon nanotubes, nanogels, nanoemulsions etc., for targeted delivery of several chemotherapeutic molecules and nucleic acid. This review also illuminates the role of hyaluronic acid (HA) in cancer therapy, interaction of HA with CD44, and various approaches to target CD44-overexpressed neoplastic cells.

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Section: Cd44 Engineered Nanocarriers For Cancer Therapymentioning

confidence: 99%