An insight into aptamer engineered dendrimer for cancer therapy

Sheikh, Afsana; Kesharwani, Prashant

doi:10.1016/j.eurpolymj.2021.110746

Cited by 53 publications

(12 citation statements)

References 116 publications

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“…Bone gra materials such as hydroxyapatite and tricalcium phosphate, have been widely used owing to their excellent bioconductivity and biocompatibility. [112][113][114][115][116] However, their use is limited as a bone gra material around implants owing to low strength and fracture toughness. It had been reported that a composite coating of zirconia and hydroxyapatite/ titanium alloy exhibited a complex surface topography at the micro-and nano-structural level, which dramatically enhanced the osteoblastic cell activity and osseointegration.…”

Section: Disadvantages Of Other Biomaterialsmentioning

confidence: 99%

Review on synthesis, properties and multifarious therapeutic applications of nanostructured zirconia in dentistry

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Section: Disadvantages Of Other Biomaterialsmentioning

confidence: 99%

Review on synthesis, properties and multifarious therapeutic applications of nanostructured zirconia in dentistry

et al. 2022

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“…A central core of pharmacokinetic profiles and biocompatibility are determined by a functional group at the dendrimer’s periphery [ 43 ]. Since the cationic dendrimers cause cell lysis, which damages the cell membrane due to interaction between the negatively charged cell membrane and the positively charged dendrimer surface, PEGylation and glycosylation enhance dendrimer biocompatibility [ 44 , 45 ]. Figure 3 shows the schematic representation of dendrimers.…”

Section: Nanocarriers Used In Cancer Therapymentioning

confidence: 99%

Smart Nanocarriers as an Emerging Platform for Cancer Therapy: A Review

et al. 2021

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Cancer is a group of disorders characterized by uncontrolled cell growth that affects around 11 million people each year globally. Nanocarrier-based systems are extensively used in cancer imaging, diagnostics as well as therapeutics; owing to their promising features and potential to augment therapeutic efficacy. The focal point of research remains to develop new-fangled smart nanocarriers that can selectively respond to cancer-specific conditions and deliver medications to target cells efficiently. Nanocarriers deliver loaded therapeutic cargos to the tumour site either in a passive or active mode, with the least drug elimination from the drug delivery systems. This review chiefly focuses on current advances allied to smart nanocarriers such as dendrimers, liposomes, mesoporous silica nanoparticles, quantum dots, micelles, superparamagnetic iron-oxide nanoparticles, gold nanoparticles and carbon nanotubes, to list a few. Exhaustive discussion on crucial topics like drug targeting, surface decorated smart-nanocarriers and stimuli-responsive cancer nanotherapeutics responding to temperature, enzyme, pH and redox stimuli have been covered.

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“…There are numerous strategies, such as surgical removal, radiation therapy, chemotherapy, and hormonal therapy, that have been developed for cancer treatment but each of them possesses drawbacks and side effects. Chemotherapy is the most commonly used anticancer therapy for cancer management ( Kamal et al, 2012 ; Zhao and Rodriguez, 2012 ; Sheikh and Kesharwani, 2021 ). In most cases, due to non-specific delivery, chemotherapeutic agents fail to deliver desired therapeutic effects along with generating multiple side effects ( Chadar et al, 2021 ; Kaur and Kesharwani, 2021 ; Singh and Kesharwani, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

CD44-Targeted Nanocarrier for Cancer Therapy

et al. 2022

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Cluster of differentiation 44 (CD44) is a cell surface glycoprotein overexpressed in varieties of solid tumors including pancreatic, breast, ovary, brain, and lung cancers. It is a multi-structural glycoprotein of the cell surface which is majorly involved in cell proliferation, cell-to-cell interaction, cellular migration, inflammation, and generation of immune responses. Numerous studies focus on the development of nanocarriers for active targeting of the CD44 receptor to improve efficacy of targeting chemotherapy and achieve precise chemotherapy by defining the release, uptake, and accumulation of therapeutic agents. The CD44 receptor has a selective binding affinity towards hyaluronic and chondroitin sulfate (CS). Taking this into consideration, this review focused on the role of CD44 in cancer and its therapy using several nanocarriers such as polymeric/non-polymeric nanoparticles, dendrimer, micelles, carbon nanotubes, nanogels, nanoemulsions etc., for targeted delivery of several chemotherapeutic molecules and nucleic acid. This review also illuminates the role of hyaluronic acid (HA) in cancer therapy, interaction of HA with CD44, and various approaches to target CD44-overexpressed neoplastic cells.

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An insight into aptamer engineered dendrimer for cancer therapy

Cited by 53 publications

References 116 publications

Review on synthesis, properties and multifarious therapeutic applications of nanostructured zirconia in dentistry

Review on synthesis, properties and multifarious therapeutic applications of nanostructured zirconia in dentistry

Smart Nanocarriers as an Emerging Platform for Cancer Therapy: A Review

CD44-Targeted Nanocarrier for Cancer Therapy

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