Characterization of cyclodextrin complexes of camostat mesylate by ESI mass spectrometry and NMR spectroscopy

Kwon, Soonho; Park, Sung Sup; Shin, Hoon−Kyu; Yoon, Sung‐il; Kim, Yun-tae; Kim, Young‐Jin; Lee, Kyungruyl; Lee, Sanghoo

doi:10.1016/j.molstruc.2009.09.025

Cited by 22 publications

(7 citation statements)

References 20 publications

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“…Camostat mesylate is a synthetic proteolytic enzyme inhibitor for trypsin, plasmin, kallikrein, tissue kallikrein, and thrombin. It also shows activity in the treatment of pancreatitis and reflux esophagitis ( Kwon et al, 2009 ). Nafamostat mesylate is also a synthetic serine protease inhibitor approved in Japan for the treatment of acute pancreatitis, disseminated intravascular coagulation and for anticoagulation in extracorporeal circulation ( McKee et al, 2020 ).…”

Section: Drugs Used In the Treatment Of Covid-19mentioning

confidence: 99%

What to expect from different drugs used in the treatment of COVID-19: A study on applications and in vivo and in vitro results

Marcolino

Pimentel

Barão

2020

European Journal of Pharmacology

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The end of 2019 was marked by the emergence of a new type of coronavirus (SARS-CoV-2), which has killed more than 240,000 people around the world so far. Several clinical studies are being performed to test possible drugs in response to the COVID-19 outbreak; however, there is still no treatment that is completely effective. Our goal in this paper is to bring together the results of main studies carried out with different drugs in order to help spread the knowledge about possible treatments for COVID-19 that have been suggested so far.

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Section: Drugs Used In the Treatment Of Covid-19mentioning

confidence: 99%

What to expect from different drugs used in the treatment of COVID-19: A study on applications and in vivo and in vitro results

Marcolino

Pimentel

Barão

2020

European Journal of Pharmacology

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“…Electrospray ionization mass spectrometry (ESI-MS) is a powerful means of studying reaction products and non-covalent complexes between “host-guest” with high sensitivity and rapidity, at a very low level of sample consumption [24], [25], [26].…”

Section: Introductionmentioning

confidence: 99%

Modified β-Cyclodextrin Inclusion Complex to Improve the Physicochemical Properties of Albendazole. Complete In Vitro Evaluation and Characterization

et al. 2014

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The potential use of natural cyclodextrins and their synthetic derivatives have been studied extensively in pharmaceutical research and development to modify certain properties of hydrophobic drugs. The ability of these host molecules of including guest molecules within their cavities improves notably the physicochemical properties of poorly soluble drugs, such as albendazole, the first chosen drug to treat gastrointestinal helminthic infections. Thus, the aim of this work was to synthesize a beta cyclodextrin citrate derivative, to analyze its ability to form complexes with albendazole and to evaluate its solubility and dissolution rate. The synthesis progress of the cyclodextrin derivative was followed by electrospray mass spectrometry and the acid-base titration of the product. The derivative exhibited an important drug affinity. Nuclear magnetic resonance experiments demonstrated that the tail and the aromatic ring of the drug were inside the cavity of the cyclodextrin derivative. The inclusion complex was prepared by spray drying and full characterized. The drug dissolution rate displayed exceptional results, achieving 100% drug release after 20 minutes. The studies indicated that the inclusion complex with the cyclodextrin derivative improved remarkably the physicochemical properties of albendazole, being a suitable excipient to design oral dosage forms.

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“…CDs are widely applied in the biotransformation of steroids. Natural CDs include Į-, ȕ-, Ȗ-, and į-CD, with six, seven, eight and nine glucose units, respectively [10]. Several modified hydrophilic CD derivatives, such as hydroxypropyl-ȕ-cyclodextrin, carboxymethyl-ȕ-cyclodextrin, methyl-ȕ-cyclodextrin, and SBE-ȕ-CD, have been employed to increase aqueous solubility.…”

Section: Effect Of Molar Ratio (Sbe-ȕ-cd: ȕ-Sitosterol) On ȕ-Sitostermentioning

confidence: 99%

“…Meanwhile, the biotransformation was shortened by 24 h. The low solubility of ȕ-sitosterol was a bottleneck for biotransformation. Complexation with CD enhanced the biotransformation efficiency in an aqueous fermentation system because of the special structure of CD [10]. Moreover, CD caused the changes of the cell membrane permeability, which was favorable for biotransformation [9].…”

Section: Time Course Of Biotransformationmentioning

confidence: 99%

Increased Yield of Biotransformation of Androsta-1, 4-Dien-3, 17-Dione from Β-Sitosterol by Using Sulfobutyl Ether-Β-Cyclodextrin Complexation Technique

et al. 2016

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Substrate solubility in steroid biotransformation is critical for enhancing the biotransformation of hydrophobic compounds. In this study, the sulfobutyl ether-ȕ-cyclodextrin (SBE-ȕ-CD) complexation technique was used for the biotransformation of ȕ-sitosterol to androsta-1, 4-diene-3, 17-dione with Mycobacterium ATCC25795. The production yield was increased by 26.72%, and the biotransformation course was shortened by 24h using ȕ-sitosterol/SBE-ȕ-CD inclusion complexes as substrates (1.0 g/L). Fourier transform infrared spectroscopy and differential scanning calorimetry indicated that an inclusion complex was formed between SBE-ȕ-CD and ȕ-sitosterol. The complex significantly increased the solubility of ȕ-sitosterol and improved the biotransformation efficiency of the substrate.

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Characterization of cyclodextrin complexes of camostat mesylate by ESI mass spectrometry and NMR spectroscopy

Cited by 22 publications

References 20 publications

What to expect from different drugs used in the treatment of COVID-19: A study on applications and in vivo and in vitro results

What to expect from different drugs used in the treatment of COVID-19: A study on applications and in vivo and in vitro results

Modified β-Cyclodextrin Inclusion Complex to Improve the Physicochemical Properties of Albendazole. Complete In Vitro Evaluation and Characterization

Increased Yield of Biotransformation of Androsta-1, 4-Dien-3, 17-Dione from Β-Sitosterol by Using Sulfobutyl Ether-Β-Cyclodextrin Complexation Technique

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