Characterization of Circulating CD4+CD25High Regulatory T Cells in Men With Chronic Prostatitis/Chronic Pelvic Pain Syndrome

Bai, Jian; Wang, Shaogang; Liu, Jihong; Ye, Zhangqun; Yu, Xiao; Xi, Qi; Dong-liang, HU; Su, Shiqiang

doi:10.1016/j.urology.2009.07.1229

Cited by 9 publications

(11 citation statements)

References 22 publications

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“…Published evidence has shown that CD4 + T-cells are more active in immunoreaction with self-produced proteins such as prostatic acid phosphatase (PAP) and prostatic specific acid phosphatase from prostate 19. Meanwhile, some cytokines such as interleukin (IL)-2,20 IL-6,21 IL-8,22 IL-10,20 transforming growth factor alpha,23 and monocyte chemotactic protein-124 also have changed in the presence of CP/CPPS. Speculation for this outcome may result from antigen-presenting pathogens to CD4 + T-cells by DCs that resided in foreskin,25 which then circulated through the blood, and activated T-cells.…”

Section: Discussionmentioning

confidence: 99%

Redundant prepuce increases the odds of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS)

Zhao

et al. 2014

Asian J Androl

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Some published evidence has revealed that the dendritic cells can interact with pathogens that exist in the inner foreskin. This information provides a new vision that pathogens could play a role through the redundant prepuce; numerous studies have failed to find pathogens in prostates of patients who had chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). However, no studies have reported an association between foreskin length and CP/CPPS. Hence, we conducted a retrospective case-control study of clinical data from 322 CP/CPPS patients (case group) and 341 nonCP/CPPS patients (control group). Demographic characteristics, lifestyle factors, and foreskin lengths were collected and analyzed. Multivariate logistic regression was adopted to calculate the odds of foreskin length for CP/CPPS. According to the multivariate logistic regression results, when the foreskin length covered up more than half of the glans penis, the odds for CP/CPPS were higher with an increased foreskin (odds ratio (OR): 1.66, 95% confidence interval (CI): 1.04–2.66). In comparison, when the glans penis was completely covered by the foreskin, the OR value increased to 1.86 (95% CI, 1.2–2.88). The study results showed an association between foreskin length and the odds of CP/CPPS. When the foreskin length covered up more than half of the glans penis, there were greater odds for CP/CPPS. This possible mechanism might result from interaction between pathogens and DCs in the inner foreskin, consequently activating T-cells to mediate allergic inflammation in the prostate and producing the autoimmunizations causing CP/CPPS.

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Section: Discussionmentioning

confidence: 99%

Redundant prepuce increases the odds of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS)

Zhao

et al. 2014

Asian J Androl

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“…Inflammasome activation in the prostate involves a complex interaction between danger-associated molecules (DAMPs) and glandular endothelium, macrophages, or lymphocytes [28,29], among others. It has been reported that inflammasomes can be seen in prostate epithelial cells and infiltrating macrophages [30].…”

Section: Inflammasome Is Important In Cp/cppsmentioning

confidence: 99%

Beneficial Effects of Inflammatory Cytokine-Targeting Aptamers in an Animal Model of Chronic Prostatitis

Chang

Lin

et al. 2020

IJMS

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Non-bacterial prostatitis is an inflammatory disease that is difficult to treat. Oligonucleotide aptamers are well known for their stability and flexibility in conjugating various inflammatory molecules. In this study, we investigated the effects of inflammatory cytokine-targeting aptamers (ICTA), putative neutralizers of TNF-alpha and IL-1 beta activation, on local carrageenan-induced prostate inflammation, allodynia, and hyperalgesia in rats. In vitro evaluation confirmed the binding capability of ICTA. Intraprostatic injection of carrageenan or control vehicle was performed in six-week-old rats, and ICTA (150 µg) or vehicle was administered in the prostate along with carrageenan injection. The von Frey filament test was performed to determine mechanical allodynia, and prostate inflammation was examined seven days after drug administration. Local carrageenan administration resulted in a reduction of the tactile threshold. The levels of mononuclear cell infiltration, pro-inflammatory cytokine interleukin-1 beta (b), caspase-1 (casp-1), and Nucleotide-binding oligomerization domain, Leucine rich Repeat and Pyrin domain containing proteins 1 and 3 (NALP1 and NALP3) in the prostate of rats were increased seven days after carrageenan injection. Treatment with ICTA significantly attenuated the carrageenan-induced hyperalgesia and reduced the elevated levels of proteins including TNF-a and IL-1b in the rats. Apoptosis markers, B-cell lymphoma 2-associated X protein (Bax) and caspase-3, were elevated in ICTA-treated Chronic pelvic pain syndrome (CPPS) rats. These results suggest that ICTA provides protection against local carrageenan-induced enhanced pain sensitivity, and that the neutralization of proinflammatory cytokines may result in inflammatory cell apoptosis.

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“…When treating CP/CPPS rats with MS‐275, a potent histone deacetylase inhibitor, the percentage of FoxP3 + CD4 + Treg cells in lymph nodes, and their proportion to CD4 + cells in peripheral blood increased . However, there was normal frequency of circulating CD4 + CD25 high Treg cells in CP/CPPS patients , showing that functional defects of Treg cells may also be involved in the pathogenesis of CP/CPPS.…”

Section: Cp/cpps Immune Microenvironmentmentioning

confidence: 99%

“…When treating CP/ CPPS rats with MS-275, a potent histone deacetylase inhibitor, the percentage of FoxP3 + CD4 + Treg cells in lymph nodes, and their proportion to CD4 + cells in peripheral blood increased [29]. However, there was normal frequency of circulating CD4 + CD25 high Treg cells in CP/CPPS patients [26], showing that functional defects of Treg cells may also be involved in the pathogenesis of CP/CPPS. Th17 lymphocytes are a newly discovered subset of helper CD4 + T cells, which are characterized by secreting IL-17A, IL-17F, and IL-22 as signature cytokines [30] and expressing transcription factor retinoic acid receptor-related orphan receptor c (RORc), and play a key role in a variety of tumors and chronic infections [31].…”

Section: Treg and Th17 Cells Dysfunctionmentioning

confidence: 99%

Chronic prostatitis/chronic pelvic pain syndrome and prostate cancer: study of immune cells and cytokines

Liu

Mikrani

Xie

et al. 2019

Fundamemntal Clinical Pharma

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Prostate cancer and prostatitis are both significant health concerns. A large number of studies have established that the occurrence of the two is closely related. However, the most common prostatitis, type III chronic prostatitis/chronic pelvic pain syndromes (CP/CPPS), is reported to not correlate with the occurrence of prostate cancer. Although the etiology of CP/CPPS is unknown, it may be related to the autoimmune mechanism favored by most studies. Manipulating the immune system and targeting tumor microenvironment are promising new methods for the treatment of prostate cancer. Therefore, this review focuses on the immune cells and cytokines of CP/CPPS and prostate cancer from the perspective of biological immunology and immune microenvironment. We discuss T‐regulatory (Treg) and T helper 17 (Th17) cells dysfunction, the abnormal regulation of T helper 1(Th1) and T helper 2 (Th2) cells, macrophages, and their related cytokines as key activators in CP/CPPS. In addition, we discuss the roles of Treg and Th17 cells, Th1 and Th2 cells, and related cytokines in modulating prostate cancer progression. This review highlights the concept that immune cells and cytokines provide a research strategy for the etiology of CP/CPPS and offer potentially promising targets for the treatment of prostate cancer.

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Characterization of Circulating CD4+CD25High Regulatory T Cells in Men With Chronic Prostatitis/Chronic Pelvic Pain Syndrome

Cited by 9 publications

References 22 publications

Redundant prepuce increases the odds of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS)

Redundant prepuce increases the odds of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS)

Beneficial Effects of Inflammatory Cytokine-Targeting Aptamers in an Animal Model of Chronic Prostatitis

Chronic prostatitis/chronic pelvic pain syndrome and prostate cancer: study of immune cells and cytokines

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