Characterization of chitosan–oleic acid composite films

Vargas, María; Albors, A.; Chiralt, Amparo; González‐Martínez, Chelo

doi:10.1016/j.foodhyd.2008.02.009

“…The biodegradability of the blended film in SCF also declined when the chitosan content increased, but the trend was not obvious when the blended film ratio was 1:1. This phenomenon was in line with studies that reported that chitosan is susceptible to glycosidic hydrolysis by microbial enzymes in the colon (Chourasia, Jain, 2003;McConnell, Murdan, Basit, 2008;Vargas et al, 2009).…”

Section: Influence Of the Simulated Gastrointestinal Tract Environmensupporting

confidence: 90%

Design and preparation of a novel colon-targeted tablet of hydrocortisone

Ren

¹

,

Jiang

²

,

Yang

³

et al. 2017

Braz. J. Pharm. Sci.

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The objective of this research was to design a new colon-targeted drug delivery system based on chitosan. The properties of the films were studied to obtain useful information about the possible applications of composite films. The composite films were used in a bilayer system to investigate their feasibility as coating materials. Tensile strength, swelling degree, solubility, biodegradation degree, Fourier Transform Infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), Scanning Electron Microscope (SEM) investigations showed that the composite film was formed when chitosan and gelatin were reacted jointly. The results showed that a 6:4 blend ratio was the optimal chitosan/gelatin blend ratio. In vitro drug release results indicated that the Eudragit-and chitosan/gelatin-bilayer coating system prevented drug release in simulated intestinal fluid (SIF) and simulated gastric fluid (SGF). However, the drug release from a bilayer-coated tablet in SCF increased over time, and the drug was almost completely released after 24h. Overall, colon-targeted drug delivery was achieved by using a chitosan/gelatin complex film and a multilayer coating system.

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“…The biodegradability of the blended film in SCF also declined when the chitosan content increased, but the trend was not obvious when the blended film ratio was 1:1. This phenomenon was in line with studies that reported that chitosan is susceptible to glycosidic hydrolysis by microbial enzymes in the colon (Chourasia, Jain, 2003;McConnel, Murdan, Basit, 2008;Vargas et al, 2009).…”

Section: Influence Of the Simulated Gastrointestinal Tract Environmensupporting

confidence: 90%

Design and preparation of a novel colon-targeted tablet of hydrocortisone

Ren

¹

,

Jiang

²

,

Yang

³

et al. 2016

Braz. J. Pharm. Sci.

View full text Add to dashboard Cite

The objective of this research was to design a new colon-targeted drug delivery system based on chitosan. The properties of the films were studied to obtain useful information about the possible applications of composite films. The composite films were used in a bilayer system to investigate their feasibility as coating materials. Tensile strength, swelling degree, solubility, biodegradation degree, Fourier transform infrared spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), Scanning electron microscope (SEM) investigations showed that the composite film was formed when chitosan and gelatin were jointly reacted jointly. The results showed that a 6:4 blend ratio was the optimal chitosan/gelatin blend ratio. In vitro drug release results indicated that the Eudragit-and chitosan/gelatin-bilayer coating system prevented drug release in simulated intestinal fluid (SIF) and simulated gastric fluid (SGF). However, the drug release from a bilayer-coated tablet in SCF increased over time, and the drug was almost completely released after 24 h. Overall, colon-targeted drug delivery was achieved by using a chitosan/ gelatin complex film and a multilayer coating system. Uniterms: Chitosan/gelatin complex film/drugs coating. Chitosan/multilayer coating system/drugs coating. Drugs/delivery system/colon-targeted. Tablets/bilayer-coated.O objetivo desta pesquisa foi planejar um novo sistema de liberação de fármacos direcionado ao cólon, utilizando quitosana. Estudaram-se as propriedades dos filmes a fim de obter informações úteis sobre a aplicação desses filmes compósitos. Utilizaram-se os filmes compósitos em sistema de bicamada para investigar a sua viabilidade como materiais de revestimento. Estudos de resistência à tração, grau de intumescimento, solubilidade, grau de biodegradação, no infravermelho por transformada de Fourier (FTIR), de calorimetria diferencial de varredura (DSC) e de microscopia eletrônica de varredura (SEM) mostraram que o filme compósito se formou quando a quitosana e a gelatina reagiram entre si. Os resultados mostraram que a mistura de proporção ótima foi de 6:4 de quitosana:gelatina. Resultados da liberação do fármaco in vitro indicaram que o sistema de revestimento de Eudragit e bicamada de quitosana/gelatina impediu a liberação de fármaco em fluido intestinal simulado (SIF) e em fluido gástrico simulado (SGF). Entretanto, a liberação de fármaco do comprimido revestido em bicamada no SCF aumentou ao longo do tempo e o fármaco foi quase completamente liberado após 24 h. Em geral, se obteve a forma de liberação dirigida ao cólon, utilizando filme complexo de quitosana/gelatina e sistema de revestimento multicamada.Unitermos: Quitosana/filme de complexo de gelatina. Quitosana/sistema multicamadas de revestimento/ revestimento de fármacos. Fármacos/sistema de liberação/dirigido ao cólon. Comprimidos/revestidos com bicamada.

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“…Soy PC solution (1% and 2% w/v) in ethanol and propylene glycol (5:1 v/v) containing certain amount of griseofulvin at final concentration of 0.2% w/v was mixed with the same volume of chitosan solution, vortexed and sonicated. Twenty-four milliliters of the mixture was placed in a glass Petri dish (9 cm diameter) and dried at 45°C for 48 hours and then peeled off (10,12). These formulations were named PC1Cs2 and PC2Cs2, respectively.…”

Section: Preparation Of the Filmsmentioning

confidence: 99%

Preparation, Characterization and Evaluation of Antifungal Efficacy of Chitosan/Soy Phosphatidylcholine Topical Films Containing Griseofulvin

Bavarsad

¹

,

Kouchak

²

,

Varmaziar

³

et al. 2015

Jundishapur J Nat Pharm Prod

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Background:Griseofulvin is an antifungal drug and is available as oral dosage forms. Development of topical treatment could be advantageous for superficial fungal infections of skin. The film forming property of chitosan has made it interesting for transdermal/ dermal drug delivery, but showed lack of stability. Soy phosphatidylcholine (PC), besides playing penetration enhancer and solubilizer roles, could enhance the stability and mechanical properties of the film. Films prepared from a mixture of chitosan and PC can achieve the benefits of both materials. Objectives: The aim of this study was to prepare and characterize films formed from blends of chitosan and soy PC for topical delivery of griseofulvin. Materials and Methods: Topical films composed of chitosan and soy PC were prepared by means of casting and solvent evaporation technique. The properties of the films were characterized regarding mechanical properties, swelling, ability to transmit vapor, drug release, thermal behavior and antifungal efficacy against Microsporum gypseum and Epidermophyton floccosum. Results: Presence of soy PC improved mechanical properties, lowered swelling ratio and increased stability of the films. Solubilizing activity of phospholipid resulted in higher flux of drug release from formulation containing higher amount of soy PC. Antifungal efficacy of formulations was confirmed against two species of dermatophytes in vitro. Conclusions: This topical composite film had the potential for griseofulvin delivery to superficial fungal infections.

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Characterization of chitosan–oleic acid composite films

Cited by 260 publications

References 40 publications

Design and preparation of a novel colon-targeted tablet of hydrocortisone

Design and preparation of a novel colon-targeted tablet of hydrocortisone

Design and preparation of a novel colon-targeted tablet of hydrocortisone

Preparation, Characterization and Evaluation of Antifungal Efficacy of Chitosan/Soy Phosphatidylcholine Topical Films Containing Griseofulvin

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