Preparation, Characterization and Evaluation of Antifungal Efficacy of Chitosan/Soy Phosphatidylcholine Topical Films Containing Griseofulvin

Bavarsad, Neda; Kouchak, Maryam; Varmaziar, Marzieh; Sadeghi-Nejad, Batool

doi:10.17795/jjnpp-27562

“…Both film formulations (F1 and F2) were found to be of uniform drug content as seen in the results given in Table 3 . There was no significant difference between WVTR of F1 and F2 ( P > 0.05), but these formulations showed lower WVTR (about one tenth) compared to that of the formulations in our previous study[ 25 ] that soy PC was incorporated to the chitosan film directly. Liposomes may have reduced water diffusivity by increasing the tortuosity of the film matrix and decreasing the water sorption, so improve the water barrier function.…”

Section: Discussioncontrasting

confidence: 58%

“…[ 24 ] There were no significant differences among strength of F1, F2, C1, and C2, in other words, addition of drug had no impact on mechanical properties of the films as most of the drug was encapsulated in liposomes. Interestingly, in our previous study[ 25 ] that composite film was prepared using a molecular dispersion of chitosan and soy PC, TS and EB of chitosan/soy PC film were higher than chitosan film. Ionic and hydrogen bonding interactions of chitosan and PC are possible in molecular form but that was not happened in case of adding soy PC in liposomal form to Cs.…”

Section: Discussionmentioning

confidence: 96%

Preparation and physicochemical characterization of topical chitosan-based film containing griseofulvin-loaded liposomes

Bavarsad

¹

,

Kouchak

²

,

Mohamadipour

³

et al. 2016

J Adv Pharm Technol Res

Self Cite

View full text Add to dashboard Cite

Griseofulvin is an antifungal drug and is available as oral dosage forms. Development of topical treatment could be advantageous for superficial fungal infections of the skin. In this study, films prepared from the incorporation of griseofulvin-loaded liposomes in chitosan film for topical drug delivery in superficial fungal infections. The properties of the films were characterized regarding mechanical properties, swelling, ability to transmit vapor, drug release, thermal behavior, and antifungal efficacy against Microsporum gypseum and Epidermophyton floccosum. The presence of liposomes led to decreased mechanical properties but lower swelling ratio. Higher amount of drug permeation and rate of flux were obtained by liposomes incorporated in films compared to liposomal formulations. Antifungal efficacy of formulations was confirmed against two species of dermatophytes in vitro. Therefore, two concepts of using vesicular carrier systems and biopolymeric films have been combined and this topical novel composite film has the potential for griseofulvin delivery to superficial fungal infections.

show abstract

“…Hydrophilic natural or synthetic polymers can be used to prepare fast dissolving films or strips (61)(62)(63)(64)(65). Some of the common polymers used to manufacture films or nanofibers are poly (lactide-glycolide) (40,66), chitosan (67,68), collagen (69), poly (lactide-caprolactone) (70, 71), cellulose acetate phthalate, polyvinyl alcohol (53,72,73), polyethylene glycol, polyvinyl pyrrolidone (12, 27, 47, 74-77) and cellulose derivatives such as hydroxypropyl methylcellulose (HPMC) and hydroxypropyl cellulose (HPC) (48).…”

Section: Polymersmentioning

confidence: 99%

A Review on Fast Dissolving Systems: From Tablets to Nanofibers

Bahrainian

¹

,

Abbaspour

²

,

Kouchak

³

et al. 2016

Jundishapur J Nat Pharm Prod

Self Cite

View full text Add to dashboard Cite

Context: Oral administration of drugs remains the most common and preferred route for many active pharmaceutical ingredients (APIs). However, solid oral dosage forms may be limited for patients who have swallowing problems or fear of choking. Furthermore in the case of solid dosage forms, disintegration and dissolution of dosage forms are rate limiting steps mostly for hydrophobic drugs' absorption and bioavailability. Liquid oral dosage forms such as syrups, emulsions or suspensions may be used to overcome these disadvantages but higher costs of their production and larger volume and dimensions of their packaging along with the lower precision in dose intake make the liquid oral dosage form less acceptable for patients and pharmaceutical industries. Evidence Acquisition: In order to merge the advantages of both solid and liquid oral dosage forms, fast dissolving drug delivery systems have been developed over the years. The current review aimed to discuss the pros and cons of different preparations of oral fast dissolving dosage forms including tablets, films and nanofibers. Results: Fast dissolving dosage forms rapidly dissolve in mouth without the need for additional liquid or chewing, providing ease of use for consumers, a fast absorption of drug, quick onset of action, and improved bioavailability. Various technologies to fabricate these dosage forms such as lyophilization, spray drying, solvent casting, hot melt extrusion, compaction and electrospinning are also addressed. Conclusions: Fast dissolving drug delivery systems are the promising approach in oral drug delivery systems, which can provide patient compliance especially in case of pediatrics and geriatrics. They can also lead to quick action of drugs and enhanced bioavailability.

show abstract

“…Hydrophilic natural or synthetic polymers can be used to prepare fast dissolving films or strips (61)(62)(63)(64)(65). Some of the common polymers used to manufacture films or nanofibers are poly (lactide-glycolide) (40,66), chitosan (67,68), collagen (69), poly (lactide-caprolactone) (70,71), cellulose acetate phthalate, polyvinyl alcohol (53,72,73), polyethylene glycol, polyvinyl pyrrolidone (12, 27, 47, 74-77) and cellulose derivatives such as hydroxypropyl methylcellulose (HPMC) and hydroxypropyl cellulose (HPC) (48).…”

Section: Polymersmentioning

confidence: 99%

A Review on Fast Dissolving Systems: From Tablets to Nanofibers

Bahrainian

¹

,

Abbaspour

²

,

Kouchak

³

et al. 2016

Jundishapur J Nat Pharm Prod

View full text Add to dashboard Cite

Context: Oral administration of drugs remains the most common and preferred route for many active pharmaceutical ingredients (APIs). However, solid oral dosage forms may be limited for patients who have swallowing problems or fear of choking. Furthermore in the case of solid dosage forms, disintegration and dissolution of dosage forms are rate limiting steps mostly for hydrophobic drugs' absorption and bioavailability. Liquid oral dosage forms such as syrups, emulsions or suspensions may be used to overcome these disadvantages but higher costs of their production and larger volume and dimensions of their packaging along with the lower precision in dose intake make the liquid oral dosage form less acceptable for patients and pharmaceutical industries. Evidence Acquisition: In order to merge the advantages of both solid and liquid oral dosage forms, fast dissolving drug delivery systems have been developed over the years. The current review aimed to discuss the pros and cons of different preparations of oral fast dissolving dosage forms including tablets, films and nanofibers. Results: Fast dissolving dosage forms rapidly dissolve in mouth without the need for additional liquid or chewing, providing ease of use for consumers, a fast absorption of drug, quick onset of action, and improved bioavailability. Various technologies to fabricate these dosage forms such as lyophilization, spray drying, solvent casting, hot melt extrusion, compaction and electrospinning are also addressed. Conclusions: Fast dissolving drug delivery systems are the promising approach in oral drug delivery systems, which can provide patient compliance especially in case of pediatrics and geriatrics. They can also lead to quick action of drugs and enhanced bioavailability.

show abstract

Preparation, Characterization and Evaluation of Antifungal Efficacy of Chitosan/Soy Phosphatidylcholine Topical Films Containing Griseofulvin

Cited by 4 publications

References 32 publications

Preparation and physicochemical characterization of topical chitosan-based film containing griseofulvin-loaded liposomes

Preparation and physicochemical characterization of topical chitosan-based film containing griseofulvin-loaded liposomes

A Review on Fast Dissolving Systems: From Tablets to Nanofibers

A Review on Fast Dissolving Systems: From Tablets to Nanofibers

Contact Info

Product

Resources

About