Characterization of chemical constituents from Thymelaea hirsuta with PPARα/γ modulation activity

Yang, MH; Ali, Zainab A. M.; Khan, SI; Khan, IA

doi:10.1055/s-0034-1382545

Cited by 3 publications

(4 citation statements)

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“…However, a number of known phenolic compounds were identified in AF. Among the phenolic constituents of AF mentioned above, mangiferin, genkwanin and kaempferol have already been reported earlier as PPAR agonists [45][46][47]. Flavonoids have been reported to bind well with PPARs [48,49].…”

Section: Resultsmentioning

confidence: 91%

A Multitarget Approach to Evaluate the Efficacy of Aquilaria sinensis Flower Extract against Metabolic Syndrome

et al. 2022

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Aquilaria sinensis (Lour.) Spreng is known for its resinous secretion (agarwood), often secreted in defense against injuries. We investigated the effects of A. sinensis flower extract (AF) on peroxisome proliferator-activated receptors alpha and gamma (PPARα and PPARγ), liver X receptor (LXR), glucose uptake, and lipid accumulation (adipogenesis). Activation of PPARα, PPARγ and LXR was determined in hepatic (HepG2) cells by reporter gene assays. Glucose uptake was determined in differentiated muscle (C2C12) cells using 2-NBDG (2-deoxy-2-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]-D-glucose). Adipogenesis was determined in adipocytes (3T3-L1 cells) by Oil red O staining. At a concentration of 50 µg/mL, AF caused 12.2-fold activation of PPARα and 5.7-fold activation of PPARγ, while the activation of LXR was only 1.7-fold. AF inhibited (28%) the adipogenic effect induced by rosiglitazone in adipocytes and increased glucose uptake (32.8%) in muscle cells at 50 μg/mL. It was concluded that AF acted as a PPARα/γ dual agonist without the undesired effect of adipogenesis and exhibited the property of enhancing glucose uptake. This is the first report to reveal the PPARα/γ dual agonistic action and glucose uptake enhancing property of AF along with its antiadipogenic effect, indicating its potential in ameliorating the symptoms of metabolic syndrome.

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Section: Resultsmentioning

confidence: 91%

A Multitarget Approach to Evaluate the Efficacy of Aquilaria sinensis Flower Extract against Metabolic Syndrome

et al. 2022

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“…Yang isolated mono-and biflavonoids as genkwanin, genkwanin 5-O-β-D-glucopyranoside, genkwanin 5-O-β-D-primeveroside, tiliroside and neochamaejasmin B from T. hirsuta (Yang et al, 2014) are listed in Table 2.…”

Section: Flavonoidsmentioning

confidence: 99%

“…Yang isolated bi-and tricoumarins (daphnoretin and triumbelletin) from T. hirsuta (Yang et al, 2014) are listed in Table 2.…”

Section: Coumarinsmentioning

confidence: 99%

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Review article on Chemical constituents and Biological activity of Thymelaea hirsuta

Badawy

2019

Records of Pharmaceutical and Biomedical Sciences

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Thymelaea hirsuta a perennial, evergreen and dioecious shrub, which is native to North Africa. T. hirsuta is a widespread invasive weed and is commonly known as "Methnane". Along the history, T. hirsuta, family Thymelaeaceae, has been recognized as an important medicinal plant. Much research has been carried out on the medical applications of Methnane. The choice of the plant was based on the good previous biological study of T. hirsuta plant extract to use as anticancer, hepatoprotective and anti-diapetic. Several species of Thymelaeaceae have been the subject of numerous phytochemical studies. Initially, interest may have been due to the marked toxicity of these plants, but the widespread use of some species medicinally has certainly played a part in sustaining this interest.

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Feeding Aquilaria sinensis Leaves Modulates Lipid Metabolism and Improves the Meat Quality of Goats

Wang

Tong

et al. 2023

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Aquilaria (A.) sinensis is a medicinal plant widely grown in tropical South China. Given the abundant pruning waste of its leaves, the use of A. sinensis leaves is valuable. In this study, goats were fed a diet containing 20% A. sinensis leaves. Compared with the basal diet, feeding A. sinensis leaves to goats did not affect growth performance but considerably reduced the feeding cost. Strikingly, feeding A. sinensis leaves resulted in a significant decrease in the blood cholesterol levels (2.11 vs. 1.49 mmol/L, p = 0.01) along with a significant increase in the high-density lipoprotein levels (1.42 vs. 1.82 mmol/L, p = 0.01). There was also a tendency to lower the content of low-density lipoprotein levels in goats (0.78 vs. 0.45 mmol/L, p = 0.09). Furthermore, metabolomics analysis demonstrated that the reduction in cholesterol levels occurred in both the serum (0.387-fold change) and muscle (0.382-fold change) of goats during A. sinensis leaf feeding. The metabolic responses to feeding A. sinensis leaves suggest that the activation of lipolysis metabolism might happen in goats. These observed changes would be conducive to improving animal health and meat quality, ultimately benefiting human health.

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Characterization of chemical constituents from Thymelaea hirsuta with PPARα/γ modulation activity

Cited by 3 publications

References 0 publications

A Multitarget Approach to Evaluate the Efficacy of Aquilaria sinensis Flower Extract against Metabolic Syndrome

A Multitarget Approach to Evaluate the Efficacy of Aquilaria sinensis Flower Extract against Metabolic Syndrome

Review article on Chemical constituents and Biological activity of Thymelaea hirsuta

Feeding Aquilaria sinensis Leaves Modulates Lipid Metabolism and Improves the Meat Quality of Goats

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