Characterization of Calcium-doped Silica Gel Prepared in an Aqueous Solution

Abstract

In this study, calcium-doped silica was prepared by modifying sodium silicate-based silica gel in an aqueous solution of Ca(OH)2. Silica gels with less than 1 mm in size with different pH values were treated in Ca(OH)2 solution at concentrations ranging from 2 to 20 g/L and aged at 25, 60, and 90°C for 40 min. The BET surface area of the silica gel decreased while its pore size increased considerably after modification in Ca(OH)2 solution. The pH of 5% calcium-doped silica in water ranged from about 8.5 to 10, depending on the pH of silica gel, the aging temperature, and the concentration of the Ca(OH)2. When the concentration of the Ca(OH)2 solution was 20%, needle-like crystals of calcium silicate hydrate formed over the surface of silica gel.

Effect of Artemisinin-Loaded Mesoporous Cerium-Doped Calcium Silicate Nanopowder on Cell Proliferation of Human Periodontal Ligament Fibroblasts

“…Calcium-doped mesoporous materials exhibit improved properties such as a stable mesh structure, high surface area and high bioactivity [ 4 , 5 , 6 ]. Both calcium and silicate ions can promote bone regeneration and increase bone mineral density in vivo [ 7 , 8 , 9 ], while a few studies have unraveled the effectiveness of bioactive mesoporous calcium-silicate nanoparticles on the apical sealing of teeth root canals [ 10 ] and the odontogenic differentiation of human dental pulp stem cells [ 11 ].…”

Synthesis and Characterization of Mesoporous Mg- and Sr-Doped Nanoparticles for Moxifloxacin Drug Delivery in Promising Tissue Engineering Applications

“…From the ζ potential measurements it seems that no direct correlation exists with the hemolysis findings, although non-hemolytic MSNs presented less negative ζ potential compared to the hemolytic MSi nanoparticles. Ca 2+ and other ions of modifying elements can be attached to silica matrices by a reaction with silanol groups on the surface [ 82 ], thus reducing their overall amount. A combination of z potential, particle size, agglomeration and pore volume may result in a smaller number of silanol groups available for cell contact [ 64 ], tailoring the total hemolytic activity.…”