Characterization of Bioadhesion, Mucin‐interactions and Mucosal Permeability of Pharmaceutical Nano‐ and Microsystems

Hagesæther, Ellen; Adamczak, M.; Hiorth, Marianne; Tho, Ingunn

doi:10.1002/9781119414018.ch5

Cited by 3 publications

(1 citation statement)

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“…Multivalency is used to enhance the binding of mucoadhesive nanoparticles: these particles can achieve adhesion by electrostatic interactions, van der Waals interactions, hydrophobicity, and entangled chains, as well as by hydrogen bonding to mucosal tissue [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Novel Adhesive Nanocarriers Based on Mussel-Inspired Polyglycerols for the Application onto Mucosal Tissues

et al. 2022

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A synthetic route for adhesive core-multishell (CMS) nanocarriers for application to the oral mucosa was established using mussel-inspired catechol moieties. The three CMS nanocarriers with 8%, 13%, and 20% catechol functionalization were evaluated for loading capacity using Nile red, showing an overall loading of 1 wt%. The ability of Nile red loaded and functionalized nanocarriers to bind to a moist mucosal surface was tested in two complementary adhesion assays under static and dynamic conditions using monolayers of differentiated gingival keratinocytes. Adhesion properties of functionalized nanocarriers were compared to the adhesion of the non-functionalized nanocarrier. In both assays, the CMS nanocarrier functionalized with 8% catechol exhibited the strongest adhesion compared to its catechol-free counterpart and the CMS nanocarriers functionalized with 13% and 20% catechol.

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Section: Introductionmentioning

confidence: 99%