Characterization of benign and malignant melanocytic skin lesions using optical coherence tomography in vivo

Gambichler, Thilo; Regeniter, Philipp; Bechara, Falk G.; Orlikov, Alexej; Vasa, R; Moussa, Georg; Stücker, Markus; Altmeyer, Peter; Hoffmann, Klaus

doi:10.1016/j.jaad.2007.05.029

Cited by 149 publications

(134 citation statements)

References 33 publications

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“…Although icicle-like structures have been described in malignant melanomas, these fi ndings are not specifi c enough [ 15 ] . Penetration depth may be determined to a thickness of about 1.5 mm.…”

Section: Discussionmentioning

confidence: 95%

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Optical coherence tomography: its role in daily dermatological practice

Schmitz¹,

Reinhold²,

Bierhoff

et al. 2013

J Deutsche Derma Gesell

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SummaryOptical coherence tomography (OCT) is a non-invasive, tomographic imaging technique which generates high-resolution in-vivo images up to mid-dermal layers. Due to continuous technological improvements, OCT is moving from research projects into daily dermatological practice. It can complement other imaging methods like highfrequency ultrasound or confocal microscopy. There is a wide variety of indications for OCT. In addition to aiding in the diagnosis and clinical monitoring of inflammatory dermatoses, OCT is a very useful and feasible technique in dermato-oncology.

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Section: Discussionmentioning

confidence: 95%

“…OCT: The DEJ could not be clearly discerned and there were vertical, icicle-like structures as seen in malignant melanocytic processes [ 15 ] . Signs of basal cell carcinoma, such as nests of basaloid cells, were not detected (Figure 3 b).…”

Section: Applications In Dermatology Practicementioning

confidence: 98%

Optical coherence tomography: its role in daily dermatological practice

Schmitz¹,

Reinhold²,

Bierhoff

et al. 2013

J Deutsche Derma Gesell

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“…OCT features of malignant melanoma were large vertically arranged icicle-shaped structures, which mainly corresponded to dense dermal infiltrates of melanocytes as confirmed by histology. However Gambichler (Gambichler, Regeniter et al 2007) were not able to detect any definitive features in OCT images enabling to differentiate tumour subtypes and tumour stages, e.g. thin vs. thick melanomas.…”

Section: Optical Coherence Tomography (Oct)mentioning

confidence: 82%

Non-Invasive Determination of Breslow Index

Amouroux¹,

Walter²

2011

Current Management of Malignant Melanoma

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“…Melanoma was characterized in MPT by features such as large intercellular distances, pleomorphic cells and the presence of dendritic cells [12]. In OCT, malignant melanoma was differentiated from benign lesions by its marked architectural disarray and presence of vertical, icicle-shaped structures [49]. Hence, a multimodal MPT/OCT system has the potential to improve the diagnostic accuracy of dermatological disorders by assessing the complimentary information obtained using both imaging modalities.…”

Section: Discussionmentioning

confidence: 99%

Three‐dimensional multiphoton/optical coherence tomography for diagnostic applications in dermatology

Alex

Weingast

Weinigel

et al. 2012

Journal of Biophotonics

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A preliminary clinical trial using state‐of‐the‐art multiphoton tomography (MPT) and optical coherence tomography (OCT) for three‐dimensional (3D) multimodal in vivo imaging of normal skin, nevi, scars and pathologic skin lesions has been conducted. MPT enabled visualization of sub‐cellular details with axial and transverse resolutions of <2 μm and <0.5 μm, respectively, from a volume of 0.35 × 0.35 × 0.2 mm3 at a frame rate of 0.14 Hz (512 × 512 pixels). State‐of‐the‐art OCT, operating at a center wavelength of 1300 nm, was capable of acquiring 3D images depicting the layered architecture of skin with axial and transverse resolutions ∼8 μm and ∼20 μm, respectively, from a volume of 7 × 3.5 × 1.5 mm3 at a frame rate of 46 Hz (1024 × 1024 pixels). This study demonstrates the clinical diagnostic potential of MPT/OCT for pre‐screening relatively large areas of skin using 3D OCT to identify suspicious regions at microscopic level and subsequently using high resolution MPT to obtain zoomed in, sub‐cellular level information of the respective regions (© 2013 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)

show abstract

Characterization of benign and malignant melanocytic skin lesions using optical coherence tomography in vivo

Cited by 149 publications

References 33 publications

Optical coherence tomography: its role in daily dermatological practice

Optical coherence tomography: its role in daily dermatological practice

Non-Invasive Determination of Breslow Index

Three‐dimensional multiphoton/optical coherence tomography for diagnostic applications in dermatology

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