Characterization of AuFe-C Core-shell Nanoparticles

Li, H; Dai, Hongjie; Li, Xing; Sinclair, Robert

doi:10.1017/s1431927606064464

Cited by 3 publications

(4 citation statements)

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“…Nanotechnology‐based agents will be developed during the next decade for MRI (Neuwalt et al., 2004; Schellenberger et al., 2002; Harishingani et al., 2003; Li et al., 2004; Kircher et al., 2003), X‐ray/CT (Srinivas et al., 2002; Rabin et al., 2006; Hainfeld et al., 2006), optical (Itoh and Osamura, 2007; Gao et al., 2005; Chan et al., 2002; Min‐Ho Lee, 2006) and ultrasound imaging (Liu et al., 2006, 2007; Wheatley et al., 2006) Nanoparticles are being developed as bi‐modal imaging agents (Mulder et al., 2006; Li et al., 2006) for MR/CT and MR/optical imaging.…”

Section: Image Contrastmentioning

confidence: 99%

Imaging and cancer: A review

2008

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Multiple biomedical imaging techniques are used in all phases of cancer management. Imaging forms an essential part of cancer clinical protocols and is able to furnish morphological, structural, metabolic and functional information. Integration with other diagnostic tools such as in vitro tissue and fluids analysis assists in clinical decision-making. Hybrid imaging techniques are able to supply complementary information for improved staging and therapy planning. Image guided and targeted minimally invasive therapy has the promise to improve outcome and reduce collateral effects. Early detection of cancer through screening based on imaging is probably the major contributor to a reduction in mortality for certain cancers. Targeted imaging of receptors, gene therapy expression and cancer stem cells are research activities that will translate into clinical use in the next decade. Technological developments will increase imaging speed to match that of physiological processes. Targeted imaging and therapeutic agents will be developed in tandem through close collaboration between academia and biotechnology, information technology and pharmaceutical industries.

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Section: Image Contrastmentioning

confidence: 99%

Imaging and cancer: A review

2008

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“…The graphitization is carried out by a modification of a process from growing carbon nanotubes, by heating in a methane hydrogen mixture at 900°C[7–10]. …”

Section: Methodsmentioning

confidence: 99%

“…The suspension is dropped onto a holey carbon TEM grid (Ted Pella PELCO © 200 mesh copper) and allowed to air dry. Further details regarding synthesis and characterization can be found in [8–10]. …”

Section: Methodsmentioning

confidence: 99%

“…The small particle diameters are designed to ensure that they are in the superparamagnetic size range to avoid magnetic interactions between them. To characterize both their structure and the degree of graphitization, only high resolution transmission electron microscopy (HREM) is applicable, and this paper therefore describes the results which have been obtained [8–10]. …”

Section: Introductionmentioning

confidence: 99%

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HREM analysis of graphite-encapsulated metallic nanoparticles for possible medical applications

Sinclair

Madsen

et al. 2013

Ultramicroscopy

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High resolution electron microscopy has been applied to study the structure of metallic nanoparticles. These have sparked considerable interest as contrast agents in the field of biological imaging, including in magnetic resonance imaging (MRI) and computed tomography (CT). Here, we describe a method of synthesizing sub-10nm superparamagnetic metal and alloy nanoparticles by reduction of metallic salts. Annealing at 900°C in a methane/hydrogen environment forms a thin graphitic-carbon shell which is expected to improve stability, biocompatibility, and functionalization. Subsequent high resolution electron microscopy verifies graphitization and allows for crystallographic analysis. Most particles consist of single crystals in the phase predicted for the bulk material at the annealing temperature. Electron energy loss spectroscopy, energy dispersive X-ray spectroscopy and lattice constant measurements show large variation in composition for alloy nanoparticles from a single synthesis. The magnetization relaxation time (T2) measurements demonstrate that Fe and AuFe nanoparticles compete with commercially available iron oxide MRI contrast agents. X-ray attenuation measurements of an AuFe alloy nanoparticle solution gave a relative radiodensity of 280 Hounsfield Units, demonstrating promise as a dual-purpose contrast agent in CT and MRI. Long term stability in an atmospheric environment was also tested, with no signs of corrosion or oxidation after several years of storage.

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Synthesis and characterization of graphite-encapsulated iron nanoparticles from ball milling-assisted low-pressure chemical vapor deposition

Ağaoğulları

Madsen

Ögüt

et al. 2017

Carbon

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Graphite-encapsulated Fe nanoparticles were synthesized using a combined method of high-energy ball milling and low-pressure chemical vapor deposition (LPCVD). Fe2O3 and graphite powders were milled to increase their surface areas and obtain a more homogeneous distribution. LPCVD was performed at a pressure of ~0.57 Torr in a tube furnace under a CH4/H2 atmosphere at 1050°C for 1 and 3 h. As-synthesized samples were purified in a 2 M HF solution. Characterization was performed using X-ray diffractometry (XRD), scanning and transmission electron microscopy (SEM and TEM) and alternating gradient magnetometry (AGM). XRD revealed the presence of body centered cubic (BCC) and face centered cubic (FCC) Fe phases without residual iron oxides. SEM confirmed the powders were better mixed and smaller after ball milling compared to mortar and pestle milled powders. High resolution TEM showed all nanoparticles had at least four and on average 16 graphitic layers, around an Fe core ranging from 20–300 nm. Magnetic measurements indicated that nanoparticles exhibit soft ferromagnetic behavior with low saturation magnetization (17–21 emu/g) and coercivity (110 Oe). A chemical stability test performed in a 2 M HCl solution showed that graphitic shells did not degrade, nor was there evidence of core dissolution or shell discontinuity.

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Characterization of AuFe-C Core-shell Nanoparticles

Abstract: Extended abstract of a paper presented at Microscopy and Microanalysis 2006 in Chicago, Illinois, USA, July 30 – August 3, 2005

Cited by 3 publications

References 2 publications

Imaging and cancer: A review

Imaging and cancer: A review

HREM analysis of graphite-encapsulated metallic nanoparticles for possible medical applications

Synthesis and characterization of graphite-encapsulated iron nanoparticles from ball milling-assisted low-pressure chemical vapor deposition

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