Characterization of Ascidian Plasma Growth Factors Promoting the Proliferation of Mouse Thymocytes

Iizuka, Junko; Azumi, Kaoru; Yokosawa, Hideyoshi

doi:10.2108/zsj.14.271

Cited by 4 publications

(1 citation statement)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Burke and Watkins (69) showed that human IL-1 stimulates starfish (Pisaster ochraceus) coelomocyte phagocytosis and that an IL-1-like factor could be detected in coelomic fluids. Iizuka et al (70) have characterized several tunicate (Halocynthia rortezi) growth factors that are capable of stimulating the proliferation of mouse thymocytes. Pestarino et al (71) have localized IL-1-beta mRNA in the cerebral ganglion of the tunicate, Styela plicata.…”

Section: Macrokine Molecules and Receptors In Other Lower Speciesmentioning

confidence: 99%

Macrokines invertebrate cytokine-like molecules

Beck¹

1998

Front Biosci

View full text Add to dashboard Cite

My laboratory is applying contemporary techniques of biochemistry and molecular biology to an important emerging field in biomedicine: the evolution of the immune system. Our investigations will build upon the discoveries that key immunoregulatory molecules (i.e., cytokines), that function in the mammalian immune response appear to be present in phylogenetically distinct invertebrate species. Herein, we propose the term macrokine to describe invertebrate proteins that have vertebrate cytokine-like activities. The wide distribution of such basic elements of innate host defense responses demonstrates its antiquity in animal evolution. Through these studies we hope to identify the more ancient facets of the vertebrate innate immune response. In turn, these observations may help clarify host defense functions and responses not yet appreciated in the vertebrate immune system.

show abstract

Section: Macrokine Molecules and Receptors In Other Lower Speciesmentioning

confidence: 99%

Macrokines invertebrate cytokine-like molecules

Beck¹

1998

Front Biosci

View full text Add to dashboard Cite

show abstract

Marine Invertebrate Cell Cultures: New Millennium Trends

Rinkevich

2005

Mar Biotechnol

118

View full text Add to dashboard Cite

This review analyzes activities in the field of marine invertebrate cell culture during the years 1999 to 2004 and compares the outcomes with those of the preceding decade (1988 to 1998). During the last 5 years, 90 reports of primary cell culture studies of marine organisms belonging to only 6 taxa (Porifera, Cnidaria, Crustacea, Mollusca, Echinodermata, and Urochordata) have been published. This figure represents a 2-fold increase in the annual number of publications over the decade 1988 to 1998. Three other trends distinguish the two reviewed periods. First, in recent years studies attempting to improve cell culture methodologies have decreased, while interest in applications of already existing methodologies has increased. This reflects the effects of short-term cultures in attracting new researchers and scientific disciplines to the field. Second, only 17.8% of the recent publications used long-term cultures, compared with 30.0% of the publications in the previous decade. Third, during recent years research in cell cultures has studied fewer model species more extensively (mainly, Botryllus schlosseri, Crassostrea, Mytilus, Penaeus, and Suberites domuncula), signifying a shift from previous investigations that had studied a more diverse range of organisms. From 1988 to 1998 the phylum Mollusca was the most studied taxon (34.4%), but recent years have seen more studies of Porifera and Crustacea (30.0% and 32.2% of publications) than of Mollusca (21.1%). Still, not even a single established cell line from any marine invertebrate has yet been made available. However, the use of new cellular, genomic, and proteomic tools may fundamentally change our strategy for the development of cell cultures from marine invertebrates.

show abstract