Characterization of antigenically and genetically similar influenza C viruses isolated in Japan during the 1999–2000 season

Matsuzaki, Yoko; Takao, Shinichi; Shimada, Shin‐ichi; Mizuta, Katsumi; Sugawara, Kanetsu; Takashita, Emi; Muraki, Yasushi; Hongō, Seiji; Nishimura, Hidekazu

doi:10.1017/s0950268804002146

Cited by 24 publications

(32 citation statements)

References 33 publications

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“…We previously revealed that genetically similar strains belonging to the Yamagata/26/81-related lineage were dominantly isolated in four Japanese prefectures (Miyagi, Yamagata, Saitama, and Hiroshima) during the 1999-2000 season (14). The results of antigenic and phylogenetic analyses in the present study also showed that antigenically and genetically similar strains belonging to the Kanagawa/1/76-related lineage were dominantly isolated in various areas of Japan in 2004, along with viruses belonging to other ones in each of the Yamagata, Fukuoka, and Miyagi prefectures.…”

Section: Discussionmentioning

confidence: 99%

“…For the first and nested PCR of the NS gene, we used the primers that had been used for NS gene sequencing as reported previously (1,8,14). The primer sequences are well conserved (Ͼ95% identities) among more than 100 influenza C viruses that are registered in GenBank, and we found that influenza A (H3) viruses that circulated in 2004 were not amplified by this PCR procedure.…”

Section: Methodsmentioning

confidence: 99%

“…Moreover, we have identified some important epidemiological features of influenza C virus: antigenically and genetically different strains cocirculate in a community (10), genetic reassorting occurs frequently among strains (13), and newly emergent reassortant viruses become predominant and may be prevalent throughout Japan (13,14). However, there were only a small number of influenza C viruses isolated outside of the Yamagata and Miyagi prefectures (21,22), since the isolation of this virus is difficult due to a lack of suitable cell line for isolation of influenza C virus.…”

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confidence: 99%

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A Nationwide Epidemic of Influenza C Virus Infection in Japan in 2004

et al. 2007

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a total of 131 influenza C viruses were detected by cell culture or reverse transcription-PCR (RT-PCR) from specimens that were obtained from children with acute respiratory symptoms in 10 prefectures across Japan. Influenza C virus was identified most frequently in the Miyagi (1.4%, 45 of 3,226 specimens) and Yamagata (2.5%, 31 of 1,263 specimens) prefectures, and the frequency in this year was the highest since 1990. Phylogenetic analysis of the hemagglutinin esterase gene of the 13 strains isolated in nine prefectures revealed that genetically similar strains belonging to the Kanagawa/1/76-related lineage dominantly spread throughout Japan. During the 2004 influenza season, influenza C virus coexisted with epidemics of influenza A virus (H3 strain), and 12 cases were identified from patients who had been diagnosed with influenza-like illness (7 were detected by RT-PCR, and 5 were detected by culture). A comparison of specimens that were found positive by culture with those found positive only by RT-PCR shows that the amount of virus in PCR-positive specimens tended to be lower than in isolation-positive specimens. Although the mean peak temperature in patients in the PCR-positive group was slightly lower, there were no significant differences in characteristics between specimens (i.e., kind of specimen, period from onset to specimen collection, age distribution of patients, and severity of illness). These results suggest that an epidemic of influenza C virus occurred on a national scale during this period and that RT-PCR can be an effective supplemental tool for the evaluation of clinical and epidemiological information.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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confidence: 99%

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A Nationwide Epidemic of Influenza C Virus Infection in Japan in 2004

et al. 2007

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“…However, AM cells have been shown to be susceptible to influenza C viruses [25,48]. These findings indicate that 9-O-acetyl sialic acid may be carried on Olinked glycoproteins or glycolipids, such as gangliosides [8,49], in AM cells of chicken embryonated eggs.…”

Section: Methodsmentioning

confidence: 99%

Analysis of N-glycans in embryonated chicken egg chorioallantoic and amniotic cells responsible for binding and adaptation of human and avian influenza viruses

et al. 2008

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The initial step essential in influenza virus infection is specific binding of viral hemagglutinin to host cell-surface glycan receptors. Influenza A virus specificity for the host is mediated by viral envelope hemagglutinin, that binds to receptors containing glycans with terminal sialic acids. Human viruses preferentially bind to α2→6 linked sialic acids on receptors of host cells, whereas avian viruses are specific for the α2→3 linkage on the target cells. Human influenza virus isolates more efficiently infect amniotic membrane (AM) cells than chorioallantoic membrane (CAM) cells. N-glycans were isolated from AM and CAM cells of 10-day-old chicken embryonated eggs and their structures were analyzed by multi-dimensional HPLC mapping and MALDI-TOF-MS techniques. Terminal Nacetylneuraminic acid contents in the two cell types were similar. However, molar percents of α2→3 linkage prefer- Glycoconj J (2009) 26:433-443

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“…We suspect that influenza C viruses, which have similar genome composition, are circulating worldwide, as are influenza A and B viruses, because most of the isolates in various areas of the world in the 1970s and 1980s were closely related to the contemporary Japanese viruses in all gene segments, as reported previously (13). Furthermore, future surveillance will try to determine if adult infections are the major means by which influenza C virus spreads.…”

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confidence: 75%