Characterization of Antidiabetic and Antihypertensive Properties of Canary Seed (Phalaris canariensis L.) Peptides

Abstract

Canary grass is used as traditional food for diabetes and hypertension treatment. The aim of this work is to characterize the biological activity of encrypted peptides released after gastrointestinal digestion of canary seed proteins. Canary peptides showed 43.5% inhibition of dipeptidyl peptidase IV (DPPIV) and 73.5% inhibition of angiotensin-converting enzyme (ACE) activity. An isolated perfused rat heart system was used to evaluate the canary seed vasoactive effect. Nitric oxide (NO), a major vasodilator agent, was evaluated in the venous effluent from isolated perfused rat heart. Canary seed peptides (1 μg/mL) were able to induce the production of NO (12.24 μM) in amounts similar to those induced by captopril (CPT) and bradykinin (BK). These results show that encrypted peptides in canary seed have inhibitory activity against DPPIV and ACE, enzymes that are targets for diabetes and hypertension treatments.

Fractionation of hydrolysate from corn germ protein by ultrafiltration: In vitro antidiabetic and antioxidant activity

“…Another approaches for control of diabetes are through inhibition of dipeptidyl peptidase‐IV (DPP‐IV) activity that increases the half‐life of total circulating GLP‐1 (peptides that stimulates glucose‐dependent insulin secretion in pancreatic β‐cells) by preventing it from degradation and inactivation. Thereafter, prolonged secretion of insulin resulted in more absorption of glucose by the tissues and decreased in plasma glucose (Estrada‐Salas, Montero‐Morán, Martínez‐Cuevas, González, & Barba de la Rosa, 2014; Vilcacundo et al, 2017; Zambrowicz et al, 2015). Hence, in the past few years, enzyme inhibitors have developed for control of the type 2 diabetes.…”

48. Canary Grass – a special crop for birds and biodiversity

“…as an agent that protects the yarn during processing and improves cloth characteristics). Canary seed has been used as a folk medicine for diabetes and hypertension, and recent research (Estrada-Salas et al 2014) has indicated that it has some potential therapeutic value. Ground hulled canary seed is currently marketed as a powder for preparing a beverage called 'Canary Seed Milk' in Mexico and the US, but apparently for use as a traditional medicine rather than for food.…”

Chemical Composition, Characteristics Profiles and Bioactivities of Tunisian<i> Phalaris canariensis </i>Seed: A Potential Source of &#969;-6 and &#969;-9 Fatty Acids

“…Currently this crop is solely used as food for caged and wild birds. However the unique composition and characteristics of Phalaris canariensis make it a promising cereal for food and industrial uses [8,9,10]. It is spread throughout the entire northern hemisphere, particularly in Asia, Europe, North America and North Africa.…”