Characterization of antibacterial and adhesion properties of chitosan-modified glass ionomer cement

Abstract

Incorporation of acidic solutions of chitosan in the polyacrylic acid liquid of GIC at v/v ratios of 5-10% improved the antibacterial properties of conventional glass ionomer cement against S. mutans without adversely affecting its bonding to dentin surface.

Characterization of Chitosan/TiO2 Nano‐Powder Modified Glass‐Ionomer Cement for Restorative Dental Applications

“…TiO 2 nano‐powders/particles (NP) are nano‐material which were used as reinforcing and antibacterial modifier for many dental materials, including GIC, with promising results . Chitosan, a natural biocompatible poly‐aminosaccharide, has proven its potent antibacterial effect against oral biofilms, specifically S. mutans . Accordingly, the potential applications of chitosan in preventive and restorative dentistry were recently intensively investigated for its possible clinical applications …”

“…Chitosan, a natural biocompatible poly‐aminosaccharide, has proven its potent antibacterial effect against oral biofilms, specifically S. mutans . Accordingly, the potential applications of chitosan in preventive and restorative dentistry were recently intensively investigated for its possible clinical applications …”

“…At every 24 hours, the specimens were transferred to new wells containing fresh growth medium for 3 days to form biofilms. For each group, 28 specimens were identified to be investigated qualitatively with SEM ( n = 5) and confocal microscopy ( n = 5); and quantitatively by colony forming unit counts (CFU) ( n = 9) and MTS assay for cells viability ( n = 9) following our previously described protocols …”

“…Chitosan exhibits a wide spectrum of antibacterial activity and high killing rate against gram‐positive and gram‐negative bacteria associated with lower toxicity toward mammalian cells . Modification of the liquid phase of GICs with chitosan was reported previously with significant improvement in the mechanical and antibacterial properties at optimum chitosan concentration of 10% ( v/v ). In addition, chitosan was shown to catalyze fluoride ions release.…”

Chitosan in different concentrations added to a two-step etch-and-rinse adhesive system: influence on bond strength to dentin

“…Different studies evaluated the inclusion of chitosan into different restorative materials, as resin cement modified [24] and glass ionomer cements [25]. When included into adhesive systems, it was demonstrated that the inclusion of low concentrations of chitosan (0.12 and 0.25%) do not compromise of bond strength to dentin compared to a higher concentration (1%) [21].…”