Characterization of animal sporotrichosis in a highly urbanized area

Andrade, Elisa Helena Paz; Moreira, Simone Magela; Paiva, Marcelo Teixeira; Zibaoui, Hassan Melo; Salvato, Lauranne Alves; Azevedo, María Isabel de; Oliveira, Camila Stefanie Fonseca de; Soares, Danielle Ferreira de Magalhães; Keller, Kelly Moura; Magalhães, Sérgio Leão; Morais, Maria Helena Franco; Costa, José Renato de Rezende; Bastos, Camila de Valgas e

doi:10.1016/j.cimid.2021.101651

Cited by 7 publications

(6 citation statements)

References 18 publications

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“…Most cats with sporotrichosis included in our study were young adults (mean age of 3.96 years), male, and domestic short hairs with uncontrolled outdoor access, similar to previous reports [31][32][33]. Specific demographic characteristics such as age and outdoor access, as well as natural and sexual behaviors of cats, may play a critical role in the transmission of sporotrichosis from cat to cat, cat to dog, and cat to human.…”

Section: Discussionsupporting

confidence: 85%

Phenotypic and Genotypic Characterization and Antifungal Susceptibility of Sporothrix schenckii sensu stricto Isolated from a Feline Sporotrichosis Outbreak in Bangkok, Thailand

Yingchanakiat

Limsivilai

Sunpongsri

et al. 2023

JoF

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Sporotrichosis, an invasive fungal infection caused by Sporothrix schenckii, has emerged in Southeast Asia, affecting cats and posing a potential zoonotic risk to humans. We evaluated 38 feline sporotrichosis cases in and around Bangkok, Thailand, from 2017 to 2021. The isolates were phenotypically and genotypically characterized. The cats infected with sporotrichosis were mainly young adults, males, and domestic short hairs with uncontrolled outdoor access, and they lived in Bangkok. All isolates showed low thermotolerance and converted to the yeast phase at 35 °C. Based on the internal transcribed spacer region of rDNA sequences, our strains belonged to S. schenckii sensu stricto and clustered with clinical clade D. Based on the concatenated tree of calmodulin and beta-tubulin genes, five groups of S. schenckii were generated, and the monophyletic clade, Group II, of Thai strains was recognized. In vitro antifungal susceptibility testing demonstrated that the MIC50 of our isolates to amphotericin B, itraconazole, and posaconazole were within the limit of the species-specific epidemiological cutoff values, suggesting that the organisms were the wild type. Addressing the outbreak of feline sporotrichosis in Thailand by providing guidelines for diagnosis and effective treatment may help control the spread of disease and reduce the risk of cat-transmitted sporotrichosis to humans.

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Section: Discussionsupporting

confidence: 85%

Phenotypic and Genotypic Characterization and Antifungal Susceptibility of Sporothrix schenckii sensu stricto Isolated from a Feline Sporotrichosis Outbreak in Bangkok, Thailand

Yingchanakiat

Limsivilai

Sunpongsri

et al. 2023

JoF

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“…Another study showed that wandering freely on the streets is a significant risk factor for Sporothrix spp. infection in cats, even after desexing 8 .…”

Section: Discussionmentioning

confidence: 99%

Household outbreak of sporotrichosis: towards the One Health approach

Andrade

Bastos

Silva³

et al. 2022

Rev. Soc. Bras. Med. Trop.

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Although sporotrichosis requires a broad approach for control, few reports have described the relationship between the index case and secondary contacts. In the present work, we report an outbreak involving a woman, a dog, and two cats from the same household environment, including the clinical and epidemiological aspects and outcomes, and discuss the importance of a One Health approach to face this neglected disease. The joint efforts of professionals such as veterinarians and physicians are essential for early diagnosis and surveillance, which contributes to the rapid identification and control of zoonotic sporotrichosis outbreaks.

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“…No passado, a doença era comumente adquirida em acidentes com restos vegetais, sendo conhecida como "doença do jardineiro". Em grande parte do mundo, esta ainda é a forma mais comum de contágio, porém, no Brasil, o contágio mais comum atualmente se dá através de arranhões, mordidas ou contato direto da pele lesionada com gatos doentes ou portadores do fungo, tendo se tornado uma importante zoonose, com risco de causar uma epidemia humana nas áreas endêmicas (Andrade et al, 2021;Bento et al, 2021;Moreira et al, 2021;Rodrigues et al, 2016).…”

Section: Discussionunclassified

“…uma zoonose de grande importância epidemiológica (Andrade et al, 2021;Bento et al, 2021;Rodrigues et al, 2016). A espécie mais comum causadora da esporotricose felina no Brasil é a Sporothrix brasiliensis, que apresenta maior virulência e potencial de transmissão do que as demais espécies (Gremião et al, 2017;Rodrigues et al, 2013).…”

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Esporotricose felina responsiva ao tratamento com itraconazol em São Paulo: Relato de caso

Bedrikow¹,

Novais-Mencalha²

2022

Pubvet

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A esporotricose felina é uma doença cada vez mais prevalente na rotina clínica veterinária, já sendo considerada epidêmica em várias regiões do Brasil. O diagnóstico muitas vezes é desafiador, e o tratamento pode ser frustrante, devido à resistência crescente do fungo às drogas comumente usadas. O presente trabalho tem o objetivo de relatar o caso de um gato errante resgatado em Guarulhos, com uma lesão esporotricótica importante na cabeça, e levado para uma clínica em um bairro nobre de São Paulo para tratamento. O mesmo consistiu em itraconazol como monoterapia, por um período de oito meses. O tratamento foi bem-sucedido e, até o presente momento, o animal não teve recidiva da doença. Nenhuma das pessoas envolvidas no resgate e cuidados com o animal apresentou lesões, apesar da desinformação de alguns acerca do aspecto zoonótico da doença, levando à falta de equipamentos de proteção individual para manejar o animal. Isso mostra a necessidade de políticas públicas focadas em ensinar a população a respeito das principais zoonoses, e programas mais eficientes de castração de animais errantes.

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Characterization of animal sporotrichosis in a highly urbanized area

Cited by 7 publications

References 18 publications

Phenotypic and Genotypic Characterization and Antifungal Susceptibility of Sporothrix schenckii sensu stricto Isolated from a Feline Sporotrichosis Outbreak in Bangkok, Thailand

Phenotypic and Genotypic Characterization and Antifungal Susceptibility of Sporothrix schenckii sensu stricto Isolated from a Feline Sporotrichosis Outbreak in Bangkok, Thailand

Household outbreak of sporotrichosis: towards the One Health approach

Esporotricose felina responsiva ao tratamento com itraconazol em São Paulo: Relato de caso

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