Characterization of an O-desmethylangolensin-producing bacterium isolated from human feces

Yokoyama, Shin-ichiro; Niwa, Toshio; Osawa, Toshihiko; Suzuki, Tohru

doi:10.1007/s00203-009-0524-5

Cited by 47 publications

(22 citation statements)

References 40 publications

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“…In addition to glycolysis/gluconeogenesis pathway-related genes, the genome also possesses genes for butyrate metabolism (ato, buk, ptb, bcd, fad, and paaH). This result corresponds with our previous report that the strain produces lactate and butyrate as end products of glucose fermentation (7). The VFDB result indicates that the strain possesses a gene for a tetracycline resistance protein (tetW) and urease and urease accessory protein (ureG) genes (CXIVA_10010, CXIVA_25610, and CXIVA_25570, respectively).…”

supporting

confidence: 91%

Complete Genomic Sequence of the O -Desmethylangolensin-Producing Bacterium Clostridium rRNA Cluster XIVa Strain SY8519, Isolated from Adult Human Intestine

Yokoyama¹,

Oshima

Nomura

et al. 2011

J Bacteriol

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supporting

confidence: 91%

Complete Genomic Sequence of the O -Desmethylangolensin-Producing Bacterium Clostridium rRNA Cluster XIVa Strain SY8519, Isolated from Adult Human Intestine

Yokoyama¹,

Oshima

Nomura

et al. 2011

J Bacteriol

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“…HGH136 , and Clostridium sp. SY8519 are efficient O‐DMA producers . On the contrary, bacterial genera including Slakia sp.…”

Section: Absorption Bioavailability and Metabolism Of Daidzeinmentioning

confidence: 99%

Daidzein, its effects on impaired glucose and lipid metabolism and vascular inflammation associated with type 2 diabetes

et al. 2018

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Over the last decades, the incidence of type 2 diabetes (T2D) is increasing substantially. Emerging evidences from epidemiological studies have shown the association between higher intake of soy isoflavones and reduced risk of T2D and its associated health risks. Daidzein, a soy isoflavone, has been found to have a promising therapeutic potential in managing T2D pathophysiology. Fermented soybean is the major source of daidzein; however, it can also be formed via the consumption of its glycosylated moiety, daidzin with subsequent hydrolysis by intestinal bacterial enzyme. Many studies reported the prophylactic effect of daidzein on the improvement of hyperglycemia, insulin resistance, dislipidemia, obesity, inflammation, and other complications associated with T2D. The molecular mechanisms underlying the action of daidzein include diverged pathways where daidzein has been shown to interact with several signaling molecules and receptors to achieve desirable effect. Although the specific molecular mechanism is still elusive, further studies are thus needed to understand it in detail. In this review, we discuss the antidiabetic potential of daidzein with respect to the evidences from various clinical, preclinical, and cell culture studies and the underlying molecular mechanism in a precise way to have a comprehensive account on this isoflavone with promising therapeutic potential. © 2018 BioFactors, 44(5):407-417, 2018.

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“…After C‐ ring‐fission, flavonoids can be further metabolized by the gut microbiota through demethylation and dehydroxylation reactions ( Table 2 ). [ 21,23,26,30,32–34,36–39,43–79 ] Simpler phenolic compounds derived from A and B rings are released as a product of this microbial degradation of flavonoids in the gut. The majority of these metabolites consist of acid or aldehyde phenolics with 1, 2, and(or) 3 hydroxyl and methyl ester radicals.…”

Section: The Two‐way Interaction Between Phenolics and Gut Microbiotamentioning

confidence: 99%

Where to Look into the Puzzle of Polyphenols and Health? The Postbiotics and Gut Microbiota Associated with Human Metabotypes

Cortés‐Martín

Selma

Tomás‐Barberán

et al. 2020

Molecular Nutrition Food Res

189

240

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The full consensus on the role of dietary polyphenols as human-healthpromoting compounds remains elusive. The two-way interaction between polyphenols and gut microbiota (GM) (i.e., modulation of GM by polyphenols and their catabolism by the GM) is determinant in polyphenols' effects. The identification of human metabotypes associated with a differential gut microbial metabolism of polyphenols has opened new research scenarios to explain the inter-individual variability upon polyphenols consumption. The metabotypes unequivocally identified so far are those involved in the metabolism of isoflavones (equol and(or) O-desmethylangolesin producers versus non-producers) and ellagic acid (urolithin metabotypes, including producers of only urolithin-A (UM-A), producers of urolithin-A, isourolithin-A, and urolithin-B (UM-B), and non-producers (UM-0)). In addition, the microbial metabolites (phenolic-derived postbiotics) such as equol, urolithins, valerolactones, enterolactone, and enterodiol, and 8-prenylnaringenin, among others, can exert differential health effects. The knowledge is updated and position is taken here on i) the two-way interaction between GM and polyphenols, ii) the evidence between phenolic-derived postbiotics and health, iii) the role of metabotypes as biomarkers of GM and the clustering of individuals depending on their metabotypes (metabotyping) to explain polyphenols' effects, and iv) the gut microbial metabolism of catecholamines to illustrate the intersection between personalized nutrition and precision medicine.A. Cortés-Martín, Dr.

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Characterization of an O-desmethylangolensin-producing bacterium isolated from human feces

Cited by 47 publications

References 40 publications

Complete Genomic Sequence of the O -Desmethylangolensin-Producing Bacterium Clostridium rRNA Cluster XIVa Strain SY8519, Isolated from Adult Human Intestine

Complete Genomic Sequence of the O -Desmethylangolensin-Producing Bacterium Clostridium rRNA Cluster XIVa Strain SY8519, Isolated from Adult Human Intestine

Daidzein, its effects on impaired glucose and lipid metabolism and vascular inflammation associated with type 2 diabetes

Where to Look into the Puzzle of Polyphenols and Health? The Postbiotics and Gut Microbiota Associated with Human Metabotypes

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