Characterization of a seal morbillivirus

Cosby, S. L.; McQuaid, Stephen; Duffy, Noel; Lyons, C.; Rima, B. K.; Allan, Gordon; McCullough, S J; Kennedy, S.; Smyth, Joan A.; McNeilly, F.; Craig, CR; Örvell, Claes

doi:10.1038/336115b0

Cited by 107 publications

(72 citation statements)

References 4 publications

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“…With the exception of one MAb (clone 3.991, NP4), the 17 MAbs used in the study by Cosby et al (1988) reacted identically with the Irish and Danish isolates of PDV. The PDV isolate from Holland (Osterhaus et al, 1989b;Visser et al, 1990) and the Danish PDV isolate reacted identically with the 39 MAbs against CDV and the 16 MAbs against PDV, in simultaneous ELISA testing (C. Orvell et al, unpublished data).…”

Section: Discussionmentioning

confidence: 99%

“…Different numbers of passages of the isolate in mink did not change the antigenic composition of the virus in tests with the MAbs. Two other isolates of PDV from the North Sea have been analysed with the MAbs against CDV (Cosby et al, 1988;Osterhaus et al, 1989b;Visser et al, 1990).…”

Section: Discussionmentioning

confidence: 99%

“…Of the 17 MAbs, eight were used in the study by Cosby et al (1988), and these antibodies reacted similarly with the Irish isolate of PDV. (Fig.…”

Section: The Reaction Of 17 Mabs Directed Against the H And F Proteinmentioning

confidence: 99%

“…The newly discovered virus was named phocid or phocine distemper virus (PDV). Immunological characterization of PDV has been carried out by immunofluorescence (IF) tests with monoclonal antibodies (MAbs) directed against CDV (Cosby et al, 1988 ;Osterhaus et al I989b).…”

Section: Introductionmentioning

confidence: 99%

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Immunological relationships between phocid and canine distemper virus studied with monoclonal antibodies

Örvell

Blixenkrone-Møller²,

Svansson³

et al. 1990

Journal of General Virology

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Of the 17 MAbs, eight were used in the study by Cosby et al (1988), and these antibodies reacted similarly with the Irish isolate of PDV. (Fig.…”

Section: The Reaction Of 17 Mabs Directed Against the H And F Proteinmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Immunological relationships between phocid and canine distemper virus studied with monoclonal antibodies

Örvell

Blixenkrone-Møller²,

Svansson³

et al. 1990

Journal of General Virology

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“…PDV is a single-stranded, negative sense RNA virus that is a member of the morbillivirus genus, family Paramyxoviridae (Cosby et al 1988;Mahy et al 1988;Osterhaus & Vedder 1988). In each individual, disease typically spans a two-week period, including both the latent and infectious disease stages (Osterhaus et al 1989;Harder et al 1990;Baker 1992;Grenfell et al 1992).…”

Section: Introductionmentioning

confidence: 99%

Stage-structured transmission of phocine distemper virus in the Dutch 2002 outbreak

et al. 2009

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Heterogeneities in transmission among hosts can be very important in shaping infectious disease dynamics. In mammals with strong social organization, such heterogeneities are often structured by functional stage: juveniles, subadults and adults. We investigate the importance of such stage-related heterogeneities in shaping the 2002 phocine distemper virus (PDV ) outbreak in the Dutch Wadden Sea, when more than 40 per cent of the harbour seals were killed. We do this by comparing the statistical fit of a hierarchy of models with varying transmission complexity: homogeneous versus heterogeneous mixing and densityversus frequency-dependent transmission. We use the stranding data as a proxy for incidence and use Poisson likelihoods to estimate the 'who acquires infection from whom' (WAIFW) matrix. Statistically, the model with strong heterogeneous mixing and density-dependent transmission was found to best describe the transmission dynamics. However, patterns of incidence support a model of frequency-dependent transmission among adults and juveniles. Based on the maximum-likelihood WAIFW matrix estimates, we use the next-generation formalism to calculate an R 0 between 2 and 2.5 for the Dutch 2002 PDV epidemic.

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