Characterization of a hybrid pixel counting detector using a silicon sensor and the IBEX readout ASIC for electron detection

Fernandez-Perez, S.; Boccone, V.; Broennimann, Ch.; Disch, C.; Piazza, Luca; Radicci, V.; Rissi, M.; Schulze-Briese, Clemens; Trueb, Peter; Zambon, P.

doi:10.1088/1748-0221/16/10/p10034

Cited by 7 publications

(7 citation statements)

References 19 publications

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“…The sinc 2 function corresponding to the DQE of the ideal pixel is also shown for comparison. Incidentally, I would like to point out that both the DQE and the MTF of the SC method are in excellent agreement with the experimental data shown in [14]. 2 At zero frequency, all methods involving normalization of the events and CoG 1 have a higher DQE value with respect to the SC method and are close to the theoretical limit of 1.…”

Section: Figuresupporting

confidence: 67%

“…A custom-developed software environment-an improved version of the one described and validated in [14]-processes each individual track to mimic the physics of the charge collection and signal formation at the pixelated electrode. The generated charge distribution of each track segment was thus propagated through the remaining sensor thickness to the pixels, and a Gaussian blurring was added to reproduce the effect the thermal diffusion, with a total width depending on an initial intrinsic contribution σ 0 and, under the assumption of the constant electric field, to a contribution depending on the total travel length:…”

Section: Simulation Frameworkmentioning

confidence: 99%

“…Doseindependent DQE is also a noteworthy property [9]. For these reasons, these technologies have started being introduced to the field of electron microscopy, and many existing counting HPD like MEDIPIX2 [10], MEDIPIX3 [11], EIGER [12], EIGER2 [13], and IBEX [14] were investigated. For all electron detectors in general, and for dose-sensitive applications such as cryoEM [15] in particular, the quest for an optimization of the DQE performance is one of the driving forces of all the design phases, from the hardware to the image processing methods.…”

Section: Introductionmentioning

confidence: 99%

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Enhanced DQE and sub-pixel resolution by single-event processing in counting hybrid pixel electron detectors: A simulation study

Zambon¹

2023

Front. Phys.

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Detective quantum efficiency (DQE) is a prominent figure of merit for imaging detectors, and its optimization is of fundamental importance for the efficient use of the experimental apparatus. In this work, I study the potential improvement offered by data processing on a single-event basis in a counting hybrid pixel electron detector (HPD). In particular, I introduce a simple and robust method of single-event processing based on the substitution of the original cluster of pixels with an isotropic Gaussian function. Key features are a better filtering of the noise power spectrum (NPS) and readily allowing for sub-pixel resolution. The performance of the proposed method is compared to other standard techniques such as centroiding and event normalization, in the simulated realistic scenario of 100 keV electrons impinging on a 450 μm-thick silicon sensor with a pixel size of 75 μm, yielding the best results. The DQE can potentially be enhanced over the entire spatial frequency range, increasing from 0.86 to nearly 1 at zero frequency and extending up to 1.40 times the physical Nyquist frequency of the system thanks to the sub-pixel resolution capability.

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Section: Figuresupporting

confidence: 67%

Section: Simulation Frameworkmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Enhanced DQE and sub-pixel resolution by single-event processing in counting hybrid pixel electron detectors: A simulation study

Zambon¹

2023

Front. Phys.

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“…A key aspect of the recent boost in 3D ED-related research has been the development of ultra-high-speed hybrid-pixel detectors, as they enable fast data collection during ED rotation experiments because there is no dead time, noise-free electron counting and shutterless operation (Gru ¨ne & Mugnaioli, 2021). Hybridpixel detectors are available from several commercial providers (ASI Amsterdam Scientific Instruments, 2023;Fernandez-Perez et al, 2021;Quantum Detectors, 2023;Rigaku Corporation, 2023;X-Spectrum, 2023) as well as the 'Jungfrau' detector developed at the PSI Switzerland (Paul Scherrer Institute, 2023; Mozzanica et al, 2016). However, other hardware and software aspects in 3D ED research remain less optimized.…”

Section: Dedicated Electron Diffraction Instrumentationmentioning

confidence: 99%

“…As there are no lenses present downstream of the sample, a spacious sample environment can be realized, allowing the implementation of a five-axis goniometer and access to various custom attachments for cryo-ED or in situ studies. The Eldico ED-1 is equipped with a Dectris Quadro detector (Fernandez-Perez et al, 2021) with the following specifications: (i) zero-noise read-out, (ii) single-electron sensitivity with a detective quantum efficiency DQE > 0.8, (iii) full frame rate of 2250 (16-bit) or 4500 (8-bit) fps. The software enables intuitive switching between pre-set imaging and diffraction modes within seconds.…”

Section: Dedicated Electron Diffraction Instrumentationmentioning

confidence: 99%

Electron crystallography and dedicated electron-diffraction instrumentation

Simoncic¹,

Romeijn²,

Hovestreydt³

et al. 2023

Acta Crystallogr E Cryst Commun

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Electron diffraction (known also as ED, 3D ED or microED) is gaining momentum in science and industry. The application of electron diffraction in performing nano-crystallography on crystals smaller than 1 µm is a disruptive technology that is opening up fascinating new perspectives for a wide variety of compounds required in the fields of chemical, pharmaceutical and advanced materials research. Electron diffraction enables the characterization of solid compounds complementary to neutron, powder X-ray and single-crystal X-ray diffraction, as it has the unique capability to measure nanometre-sized crystals. The recent introduction of dedicated instrumentation to perform ED experiments is a key aspect of the continued growth and success of this technology. In addition to the ultra-high-speed hybrid-pixel detectors enabling ED data collection in continuous rotation mode, a high-precision goniometer and horizontal layout have been determined as essential features of an electron diffractometer, both of which are embodied in the Eldico ED-1. Four examples of data collected on an Eldico ED-1 are showcased to demonstrate the potential and advantages of a dedicated electron diffractometer, covering selected applications and challenges of electron diffraction: (i) multiple reciprocal lattices, (ii) absolute structure of a chiral compound, and (iii) R-values achieved by kinematic refinement comparable to X-ray data.

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Temporal and spatial variance in pixelated counting detectors with dead time and retrigger capability

Zambon¹

2022

Nuclear Instruments and Methods in Physics Research Section A:

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Characterization of a hybrid pixel counting detector using a silicon sensor and the IBEX readout ASIC for electron detection

Cited by 7 publications

References 19 publications

Enhanced DQE and sub-pixel resolution by single-event processing in counting hybrid pixel electron detectors: A simulation study

Enhanced DQE and sub-pixel resolution by single-event processing in counting hybrid pixel electron detectors: A simulation study

Electron crystallography and dedicated electron-diffraction instrumentation

Temporal and spatial variance in pixelated counting detectors with dead time and retrigger capability

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