Characterization of a dextran–coated layered double hydroxide acetylsalicylic acid delivery system and its pharmacokinetics in rabbit

Dong, Li-E.; Gou, Guojing; Lin, Johnson

doi:10.1016/j.apsb.2013.09.003

Cited by 21 publications

(12 citation statements)

References 10 publications

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“…192 Acetylsalicylic acid-dextran-coated LDH in vivo biocompatibility Dong et al designed drug-delivery systems based on dextrancoated LDHs for acetylsalicylic acid, and conducted a pharmacokinetic study with rabbits as the model animal. 160 They found the LDH-based delivery system increased the bioavailability and half-life and reduced the side effects of acetylsalicylic acid. 160 Table 2 summarizes the in vitro cytotoxic studies of inorganic nanolayers.…”

Section: Ketoprofen Ldh In Vivo Biocompatibilitymentioning

confidence: 99%

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Inorganic nanolayers: structure, preparation, and biomedical applications

Saifullah¹,

Hussein²

2015

IJN

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Hydrotalcite-like compounds are two-dimensional inorganic nanolayers also known as clay minerals or anionic clays or layered double hydroxides/layered hydroxy salts, and have emerged as a single type of material with numerous biomedical applications, such as drug delivery, gene delivery, cosmetics, and biosensing. Inorganic nanolayers are promising materials due to their fascinating properties, such as ease of preparation, ability to intercalate different type of anions (inorganic, organic, biomolecules, and even genes), high thermal stability, delivery of intercalated anions in a sustained manner, high biocompatibility, and easy biodegradation. Inorganic nanolayers have been the focus for researchers over the last decade, resulting in widening application horizons, especially in the field of biomedical science. These nanolayers have been widely applied in drug and gene delivery. They have also been applied in biosensing technology, and most recently in bioimaging science. The suitability of inorganic nanolayers for application in drug delivery, gene delivery, biosensing technology, and bioimaging science makes them ideal materials to be applied for theranostic purposes. In this paper, we review the structure, methods of preparation, and latest advances made by inorganic nanolayers in such biomedical applications as drug delivery, gene delivery, biosensing, and bioimaging.

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Section: Ketoprofen Ldh In Vivo Biocompatibilitymentioning

confidence: 99%

“…160 They found the LDH-based delivery system increased the bioavailability and half-life and reduced the side effects of acetylsalicylic acid. 160 Table 2 summarizes the in vitro cytotoxic studies of inorganic nanolayers.…”

Section: Ketoprofen Ldh In Vivo Biocompatibilitymentioning

confidence: 99%

Inorganic nanolayers: structure, preparation, and biomedical applications

Saifullah¹,

Hussein²

2015

IJN

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“…In the physiological condition, the positively charged drug-LDH is likely to tend to aggregate each other as well as to bind with nonspecific foreign substances in the bloodstream which are commonly negatively charged when clinically administrated into the human body. To increase the water solubility, bioavailability, circulation time, and accumulation in the targeted sites, those nanohybrids can be additionally coated with hydrophilic surfactants, lipid, enteric polymers, biopolymers, and biodegradable copolymers, e.g., tween [77], dextran [64,78], phospholipid [79], polyethylene glycol (PEG) [80], PEGylated phospholipid [65], Eudragit ® L100 [81], Eudragit ® S100 [82], poly (lactic-co-glycolic acid) (PLGA) [83,84], and heparin [66] (Fig. 6c).…”

Section: Bio-ldh Nanohybrids With Targeting Functionsmentioning

confidence: 99%

Bio-Layered Double Hydroxides Nanohybrids for Theranostics Applications

Park

Choi

2015

Structure and Bonding

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“…Recently, we develop acetyl salicylic acid (ASA)‐ZnAl‐LDH nanohybrid for skin care application . ASA is a salicylate derivative which possesses anti‐inflammatory effect, and for this reason, it is extensively used for pain relief in topical after shave skincare products . However, in presence of moisture it undergoes hydrolysis into salicylic and acetic acids, which reduces its pain relief effect and develops undesirable smell.…”

Section: Controlled Release Systems For Drugsmentioning

confidence: 99%

Layered Double Hydroxide‐Based Functional Nanohybrids as Controlled Release Carriers of Pharmaceutically Active Ingredients

Ray

Mosangi

Pillai

2018

The Chemical Record

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The chemical stability, degradation and penetration ability of pharmaceutically active ingredients in topical formulations are the greatest challenges because of problems with the protection of actives for long times and with delivery. Therefore, the development of unique and efficient substrate material is vital for their protection and controlled drug release. Layered double hydroxides (LDHs) known as hydrotalcite like compounds possess positive charges due to isomorphic substitutions, which are counterbalanced by hydrated exchangeable anions located in the interlayer region. Some of the active ingredient molecules can be intercalated into the inner region of the LDHs through ionic bonding, hydrogen bonding or van der Waals interaction to form nanohybrids, which are more potent for their protection and controlled-release. This account focuses on our recent research efforts and key scientific and technical challenges in the development of LDH based nanohybrids for commercial use in advanced controlled release carriers of active ingredients in topical formulations.

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Characterization of a dextran–coated layered double hydroxide acetylsalicylic acid delivery system and its pharmacokinetics in rabbit

Cited by 21 publications

References 10 publications

Inorganic nanolayers: structure, preparation, and biomedical applications

Inorganic nanolayers: structure, preparation, and biomedical applications

Bio-Layered Double Hydroxides Nanohybrids for Theranostics Applications

Layered Double Hydroxide‐Based Functional Nanohybrids as Controlled Release Carriers of Pharmaceutically Active Ingredients

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Characterization of a dextran–coated layered double hydroxide acetylsalicylic acid delivery system and its pharmacokinetics in rabbit

Cited by 21 publications

References 10 publications

Inorganic nanolayers: structure, preparation, and&nbsp;biomedical applications

Inorganic nanolayers: structure, preparation, and&nbsp;biomedical applications

Bio-Layered Double Hydroxides Nanohybrids for Theranostics Applications

Layered Double Hydroxide‐Based Functional Nanohybrids as Controlled Release Carriers of Pharmaceutically Active Ingredients

Contact Info

Product

Resources

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Inorganic nanolayers: structure, preparation, and biomedical applications

Inorganic nanolayers: structure, preparation, and biomedical applications