Characterization of a bioactive meroterpenoid isolated from the marine-derived fungus Talaromyces sp.

Hong, Xuan; Guan, Xiaoqing; Lai, Qiliang; Yu, Dehua; Chen, Zhongwei; Fu, Xiaoteng; Zhang, Beibei; Chen, Changkun; Shao, Zongze; Xia, Jin‐Mei; Qin, Jiang‐Jiang; Wang, Weiyi

doi:10.1007/s00253-022-11914-1

Cited by 16 publications

(9 citation statements)

References 37 publications

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“…As described before (Hong et al, 2022), cells were seeded at 3,000 cells per well in 96-well plates overnight. Then the cells were exposed to indicated compounds at concentrations of 1, 10, 100 μΜ.…”

Section: Cell Viability Assaymentioning

confidence: 99%

Design, synthesis, and biological characterization of a potent STAT3 degrader for the treatment of gastric cancer

Wang

Cao

et al. 2022

Front. Pharmacol.

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Gastric cancer is a common malignant tumor that threatens human health, and its occurrence and development mechanism is a complex process involving multiple genes and multiple signals. Signal transducer and activator of transcription 3 (STAT3) has been elucidated as a promising target for developing anticancer drugs in gastric cancer. However, there is no FDA-approved STAT3 inhibitor yet. Herein, we report the design and synthesis of a class of STAT3 degraders based on proteolysis-targeting chimeras (PROTACs). We first synthesized an analog of the STAT3 inhibitor S3I-201 as a ligand, using the cereblon (CRBN)/cullin 4A E3 ligase ligand pomalidomide to synthesize a series of PROTACs. Among them, the SDL-1 achieves the degradation of STAT3 protein in vitro, and exhibits good anti-gastric cancer cell proliferation activity, inhibits invasion and metastasis of MKN1 cell, and induces MKN1 cell apoptosis and arrests cell cycle at the same time. Our study shows that SDL-1 is a potent STAT3 degrader and may serve as a potential anti-gastric cancer drug, providing ideas for further development of drugs for clinical use.

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Section: Cell Viability Assaymentioning

confidence: 99%

Design, synthesis, and biological characterization of a potent STAT3 degrader for the treatment of gastric cancer

Wang

Cao

et al. 2022

Front. Pharmacol.

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“…The CCK8 experimental setup was conducted in triplicate. Data were analyzed with GraphPad Prism software to determine IC 50 of each compound ( Wang et al, 2018 , 2019 ; Hong et al, 2022 ; Lv et al, 2022 ).…”

Section: Methodsmentioning

confidence: 99%

“…The Minimum Inhibitory Concentration (MIC) was determined as the lowest concentration at which no color change occurred. All experiments were conducted in triplicate, and the average MIC values were calculated for the test compound ( Wang et al, 2018 , 2019 ; Hong et al, 2022 ; Lv et al, 2022 ).…”

Section: Methodsmentioning

confidence: 99%

Secondary metabolites from the deep-sea derived fungus Aspergillus terreus MCCC M28183

Huang,

Wang,

et al. 2024

Front. Microbiol.

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Aspergillus fungi are renowned for producing a diverse range of natural products with promising biological activities. These include lovastatin, itaconic acid, terrin, and geodin, known for their cholesterol-regulating, anti-inflammatory, antitumor, and antibiotic properties. In our current study, we isolated three dimeric nitrophenyl trans-epoxyamides (1–3), along with fifteen known compounds (4–18), from the culture of Aspergillus terreus MCCC M28183, a deep-sea-derived fungus. The structures of compounds 1–3 were elucidated using a combination of NMR, MS, NMR calculation, and ECD calculation. Compound 1 exhibited moderate inhibitory activity against human gastric cancer cells MKN28, while compound 7 showed similar activity against MGC803 cells, with both showing IC50 values below 10 μM. Furthermore, compound 16 exhibited moderate potency against Vibrio parahaemolyticus ATCC 17802, with a minimum inhibitory concentration (MIC) value of 7.8 μg/mL. This promising research suggests potential avenues for developing new pharmaceuticals, particularly in targeting specific cancer cell lines and combating bacterial infections, leveraging the unique properties of these Aspergillus-derived compounds.

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“…246 Other Talaromyces strains yielded a diverse range of metabolites including thioester-containing benzoate derivatives 765 – 770 , 247 sulfur containing spiro alkaloid 771 , unusual diacid 772 and alkaloids 773 – 777 , 248 aromatic polyketides 778 – 782 , 249 tripeptides 783 and 784 , containing an N-trans -cinnamoyl group, 250 chlorinated unsaturated alcohol 785 and coumarin derivative 786 , 251 decalin derivatives 787 and 788 , 252 meroterpenoid 789 (ref. 253) and oligophenalenone 790 and 791 and xanthoradone 792 dimers. 254 Culture of a Trametes strain yielded spiromeroterpenoids 793 and 794 (ref.…”

Section: Marine Microorganisms and Phytoplanktonmentioning

confidence: 98%

Marine natural products

Carroll,

Copp,

Grkovic

et al. 2024

Nat. Prod. Rep.

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Characterization of a bioactive meroterpenoid isolated from the marine-derived fungus Talaromyces sp.

Cited by 16 publications

References 37 publications

Design, synthesis, and biological characterization of a potent STAT3 degrader for the treatment of gastric cancer

Design, synthesis, and biological characterization of a potent STAT3 degrader for the treatment of gastric cancer

Secondary metabolites from the deep-sea derived fungus Aspergillus terreus MCCC M28183

Marine natural products

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