Characterization of 3D-printed microfluidic chip interconnects with integrated O-rings

Paydar, Omeed; Paredes, Claudia; Hwang, Yongha; Paz, J F Hernandez; Shah, N.B.; Candler, Rob N.

doi:10.1016/j.sna.2013.11.005

Cited by 71 publications

(52 citation statements)

References 14 publications

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“…Recently, Paydar et al employed a multi-material 3D printing technique to fabricate microfluidic interconnects comprising a rigid plastic for the main body and a flexible elastomer for the O-ring (Fig. 13a) [207]. This customizable and easy-to-use connector was tested and withstands pressures in excess of 400 kPa.…”

Section: Monolithic Integration Of Fluidic Connectionsmentioning

confidence: 99%

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Lab-on-a-chip devices: How to close and plug the lab?

Temiz

Lovchik

Kaigala

et al. 2015

Microelectronic Engineering

410

276

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a b s t r a c tLab-on-a-chip (LOC) devices are broadly used for research in the life sciences and diagnostics and represent a very fast moving field. LOC devices are designed, prototyped and assembled using numerous strategies and materials but some fundamental trends are that these devices typically need to be (1) sealed, (2) supplied with liquids, reagents and samples, and (3) often interconnected with electrical or microelectronic components. In general, closing and connecting to the outside world these miniature labs remain a challenge irrespectively of the type of application pursued. Here, we review methods for sealing and connecting LOC devices using standard approaches as well as recent state-of-the-art methods. This review provides easy-to-understand examples and targets the microtechnology/engineering community as well as researchers in the life sciences.

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Section: Monolithic Integration Of Fluidic Connectionsmentioning

confidence: 99%

“…(a) After[207] and (b) after[208]. (a) and (b) reproduced, respectively, with permission from Elsevier and Royal Society of Chemistry.…”

mentioning

confidence: 99%

Lab-on-a-chip devices: How to close and plug the lab?

Temiz

Lovchik

Kaigala

et al. 2015

Microelectronic Engineering

410

276

View full text Add to dashboard Cite

show abstract

“…In such cases, other techniques, including 3D printing [14][15][16], sequential overlapping layers [17][18][19], porous or impermeable membranes [20][21][22] or valves [23] may help to increase multiplicity of variables with higher level of freedom in interconnectivity. Highly sophisticated operations and effective use of the hierarchical structuring of microfluidic compartments can also be achieved in centrifugal microfluidics [24].…”

Section: Screening Cellular Responses In Microfluidic Systemsmentioning

confidence: 99%

High-throughput screening approaches and combinatorial development of biomaterials using microfluidics

2016

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Microfluidics, being a technology characterized by the engineered manipulation of fluids at the submillimeter scale, offers some interesting tools that can advance biomedical research and development. Screening platforms based on microfluidic technologies that allow high-throughput and combinatorial screening may lead to breakthrough discoveries not only in basic research but also relevant to clinical application. This is further strengthened by the fact that reliability of such screens may improve, since microfluidic systems allow close mimicking of physiological conditions. Finally, microfluidic systems are also very promising as micro factories of a new generation of natural or synthetic biomaterials and constructs, with finely controlled properties.

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“…Two or more materials could be directly used in turn by 3D printing to fabricate multiple-functional lab-on-a-chip devices. More importantly, microfluidic chips fabricated by 3D printing could mimic standard micro-titer plates and seamlessly incorporate them with control systems, solving the interfacing issue in the micro-system [39][40][41].…”

Section: Introductionmentioning

confidence: 99%

Chemical and biochemical analysis on lab-on-a-chip devices fabricated using three-dimensional printing

Zhang

2016

TrAC Trends in Analytical Chemistry

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Characterization of 3D-printed microfluidic chip interconnects with integrated O-rings

Cited by 71 publications

References 14 publications

Lab-on-a-chip devices: How to close and plug the lab?

Lab-on-a-chip devices: How to close and plug the lab?

High-throughput screening approaches and combinatorial development of biomaterials using microfluidics

Chemical and biochemical analysis on lab-on-a-chip devices fabricated using three-dimensional printing

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