Lab-on-a-chip devices: How to close and plug the lab?

Temiz, Yuksel; Lovchik, Robert D.; Kaigala, Govind V.; Delamarche, Emmanuel

doi:10.1016/j.mee.2014.10.013

Cited by 411 publications

(290 citation statements)

References 201 publications

Supporting

Mentioning

276

Contrasting

Unclassified

Order By: Relevance

“…Mark et al (2010), Iliescu et al (2012), Nge et al (2013), Temiz et al (2015), Kim and Meng (2015) The platform presented here is our attempt at creating a platform that can be used as widely as possible, but it is not possible to offer all advantages of other platforms, without any of their drawbacks. One of the advantages of this platform, a very thin channel wall, also is one of its drawbacks.…”

Section: Discussionmentioning

confidence: 99%

A versatile technology platform for microfluidic handling systems, part I: fabrication and functionalization

Groenesteijn

Boer

Lötters

et al. 2017

Microfluid Nanofluid

View full text Add to dashboard Cite

often have to be connected using (external) fluidic interconnects. This way, the fluidic interconnects will have a relatively large volume, resulting in slow response times and requiring large sample sizes.To make the ideal integrated microfluidic handling system, one fabrication process should allow many different microfluidic devices for all kinds of applications to be integrated on the same chip. The functional channels of the devices, the interconnect channels and the required interfacing electronics should be integrated on the same substrate without restricting the design options for each device.Different applications pose different demands on the fabricated system. To avoid leakage and wear, the channel walls should be mechanically strong, chemically inert and leak tight for both liquids and gasses in a large temperature range. It should be possible to locally release the channel (completely or partially) from the substrate, e.g. for thermal isolation or freedom of movement. It is required to integrate transducer structures for actuation and measurement of the devices. This can be anything from metal tracks to piezoelectric or magnetic materials or optical waveguides. Functionalization of the inside of the channel, e.g. with a catalyst or with specific coatings for (bio)chemical reactions or adhesion should be possible. Multiple channels should be able to cross each other or run inside each other. Interface electronics should be integrated directly on the chip or package to reduce noise and other parasitic effects.To be able to transfer proof-of-concepts to commercial devices, it should not only be possible to fabricate low-volume research devices, but it should also be possible to scale up the fabrication to industrial low-cost, high-volume processing in foundries. Last, and certainly not least, it should be straightforward to design the optimal fluidic element with respect to shape and size, for any application. AbstractMany microfluidic devices are made using specialized fabrication processes, limiting the ability to integrate those devices on the same chip. In this paper, a versatile technology platform is presented that allows for integration of many different devices. It provides a method to design channels in a wide range of sizes and shapes with different functionalization options in close proximity to the fluid in the channels. The latter includes release of the channels for thermal isolation or mechanical movement and metal or piezoelectric layers for actuation and read-out. The channel walls are made using silicon-rich silicon nitride to provide durable, strong, chemically inert and thermally stable channels directly below the substrate surface .

show abstract

Section: Discussionmentioning

confidence: 99%

A versatile technology platform for microfluidic handling systems, part I: fabrication and functionalization

Groenesteijn

Boer

Lötters

et al. 2017

Microfluid Nanofluid

View full text Add to dashboard Cite

show abstract

“…PTM is also increasingly integrated with other 3D printing processes to reduce the challenges of multicomponent assembly and to interface microfluidic devices with external systems 29 . Although some PTM devices can interface directly, whether, by punching holes (in a manner, similar to standard soft lithography processes) 36 , molding open wells 33,47 , and adding connectors during the curing process 34,37,48 , other PTM devices can interface indirectly by attaching to 3D-printed components that do have the desired interfaces 39 .…”

Section: Introductionmentioning

confidence: 99%

Rapid assembly of multilayer microfluidic structures via 3D-printed transfer molding and bonding

et al. 2016

View full text Add to dashboard Cite

A critical feature of state-of-the-art microfluidic technologies is the ability to fabricate multilayer structures without relying on the expensive equipment and facilities required by soft lithography-defined processes. Here, three-dimensional (3D) printed polymer molds are used to construct multilayer poly(dimethylsiloxane) (PDMS) devices by employing unique molding, bonding, alignment, and rapid assembly processes. Specifically, a novel single-layer, two-sided molding method is developed to realize two channel levels, non-planar membranes/valves, vertical interconnects (vias) between channel levels, and integrated inlet/outlet ports for fast linkages to external fluidic systems. As a demonstration, a single-layer membrane microvalve is constructed and tested by applying various gate pressures under parametric variation of source pressure, illustrating a high degree of flow rate control. In addition, multilayer structures are fabricated through an intralayer bonding procedure that uses custom 3D-printed stamps to selectively apply uncured liquid PDMS adhesive only to bonding interfaces without clogging fluidic channels. Using integrated alignment marks to accurately position both stamps and individual layers, this technique is demonstrated by rapidly assembling a six-layer microfluidic device. By combining the versatility of 3D printing while retaining the favorable mechanical and biological properties of PDMS, this work can potentially open up a new class of manufacturing techniques for multilayer microfluidic systems.

show abstract

“…However, despite significant research activities in this highly multidisciplinary field over more than two decades, only few concepts have ultimately reached the level of commercialization. Studies addressing this issue [3,4] identified the lack of standardization and integration as the main barriers to acceptance by the end-user and thus to commercial breakthrough: After acquiring one of the few commercially available microfluidic products, the operator may face difficulties in connecting the microfluidic device to ancillary hardware, such as external supplies, valves, pumps and other microfluidic components [5]. In contrast to assessments in the early stages [6], which predicted silicon-based microsystem technology as the most promising approach for microfluidic applications, soft-matter-based and hybrid solutions have become more significant [7].…”

Section: Introductionmentioning

confidence: 99%

“…Electroactive polymers (EAPs), which can be divided into electronic and ionic EAPs, are discussed in the subsequent sections (Sects. 5,6). Generally speaking, electronic EAPs respond to electrostatic charges.…”

Section: Introductionmentioning

confidence: 99%

Stimulus-active polymer actuators for next-generation microfluidic devices

Hilber

2016

Appl. Phys. A

View full text Add to dashboard Cite

Microfluidic devices have not yet evolved into commercial off-the-shelf products. Although highly integrated microfluidic structures, also known as lab-on-a-chip (LOC) and micrototal-analysis-system (lTAS) devices, have consistently been predicted to revolutionize biomedical assays and chemical synthesis, they have not entered the market as expected. Studies have identified a lack of standardization and integration as the main obstacles to commercial breakthrough. Soft microfluidics, the utilization of a broad spectrum of soft materials (i.e., polymers) for realization of microfluidic components, will make a significant contribution to the proclaimed growth of the LOC market. Recent advances in polymer science developing novel stimulus-active soft-matter materials may further increase the popularity and spreading of soft microfluidics. Stimulus-active polymers and composite materials change shape or exert mechanical force on surrounding fluids in response to electric, magnetic, light, thermal, or water/solvent stimuli. Specifically devised actuators based on these materials may have the potential to facilitate integration significantly and hence increase the operational advantage for the end-user while retaining costeffectiveness and ease of fabrication. This review gives an overview of available actuation concepts that are based on functional polymers and points out promising concepts and trends that may have the potential to promote the commercial success of microfluidics.

show abstract

Lab-on-a-chip devices: How to close and plug the lab?

Cited by 411 publications

References 201 publications

A versatile technology platform for microfluidic handling systems, part I: fabrication and functionalization

A versatile technology platform for microfluidic handling systems, part I: fabrication and functionalization

Rapid assembly of multilayer microfluidic structures via 3D-printed transfer molding and bonding

Stimulus-active polymer actuators for next-generation microfluidic devices

Contact Info

Product

Resources

About