Characterization, antioxidant activity and immunomodulatory activity of polysaccharides from the swollen culms of Zizania latifolia

Wang, Mingchun; Zhu, Pingting; Zhao, Shiwei; Nie, Chenzhipeng; Wang, Naifu; Du, Xiang; Zhou, Yibin

doi:10.1016/j.ijbiomac.2016.12.010

Cited by 134 publications

(52 citation statements)

References 39 publications

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“…The band at 2,927.76 cm −1 reflected the weak anti‐symmetrical C–H stretching vibration (Chen et al, ; You, Yin, Zhang, & Jiang, ). Band at 1,640.67 cm −1 was the bonded water's characteristic absorption and demonstrated the N–H of primary amine (Wang et al, ). The band at 1,398.47 cm −1 was corresponded to the C–H bending vibration (Jin et al, ).…”

Section: Resultsmentioning

confidence: 99%

Characterization, antioxidant, and anticancer activities of a neutral polysaccharide from Duchesnea indica (Andr.) Focke

Xiang

Лі

et al. 2019

J Food Biochem

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A neutral polysaccharide (DIP‐1) from Duchesnea indica (Andr.) Focke was obtained by hot water extraction, ethanol precipitation and chromatographic separation (DEAE‐52 cellulose anion‐exchange column and Sephadex G‐100 gel column). The physicochemical properties of DIP‐1 were elucidated by gel permeation chromatography, monosaccharide composition, Fourier transform infrared spectrometry, UV–visible spectrophotometry, scanning electron microscope and Congo red test. The results indicated that DIP‐1 was consisted of mannose, glucosamine, glucose, galactose and arabinose in a ratio of 1.00:0.42:18.36:14.17:0.81, and its molecular weight was 218.3 kDa. Meanwhile, DIP‐1 presented a straight hexahedron structure, but no triple‐helical conformation. In antioxidant activity tests, DIP‐1 exhibited powerful scavenging activities on hydroxyl, DPPH, ABTS radicals and reducing power in a dose‐dependent manner. Especially, DIP‐1 demonstrated high inhibitory activities against SKOV‐3 and Hep‐G2 cells in vitro, with IC50 values of 1.42 and 1.23 mg/ml, respectively. Practical applications D. indica has been used for a long time as a Chinese medicine for therapy of many diseases, including cancer, inflammation, leprosy, fever, bleeding and so on. At present, polysaccharides have attracted comprehensive attention because of a large range of pharmacological and biological properties, including antitumor, antidiabetic, antioxidant and immunomodulatory activity. In the present study, we purified and characterized a neutral polysaccharide from D. indica for the first time. Moreover, the neutral polysaccharide exhibits significant antioxidant and antitumor activities. Therefore, the present study laid a foundation for the high‐value application of D. indica polysaccharides in functional food and pharmaceutical industries.

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Section: Resultsmentioning

confidence: 99%

Characterization, antioxidant, and anticancer activities of a neutral polysaccharide from Duchesnea indica (Andr.) Focke

Xiang

Лі

et al. 2019

J Food Biochem

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“…It has been demonstrated that low or moderate molecular‐weight polysaccharides have stronger hydrogen‐donating ability, thus exhibiting better antioxidant activities (Ren et al, ). In addition, the high contents of arabinose and uronic acid are beneficial for the antioxidant activity of polysaccharides (Wang, Zhu, et al, ). Therefore, DFHRP‐1 had stronger antioxidant activity, which may be attributed to its higher content of arabinose and uronic acid, and moderate molecular weight.…”

Section: Resultsmentioning

confidence: 99%

“…Natural polysaccharides are widely used in the food and biomedicine fields due to their various functional and biological properties. Many previous studies showed that the functional and biological properties of polysaccharides are greatly affected by their molecular weight, monosaccharide composition, glycosidic bonds, polymerization, and conformation (Wang et al, ; Wang, Zhu, et al, ). Among these factors, molecular weight of native polysaccharides greatly influenced the functional and biological activities of polysaccharides (Xu et al, ).…”

Section: Introductionmentioning

confidence: 99%

Characterization, functional and biological properties of degraded polysaccharides from Hylocereus undatu s flowers

Zhao

Huang

2019

J Food Process Preserv

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The present study aimed at investigating the chemical degradation of the polysaccharide (designated as FHRP) isolated from the flowers of Hylocereus undatus (Haw.) Britton et Rose. Two degraded polysaccharides, designated as DFHRP‐1 and DFHRR‐2, were obtained from FHRP by using the Fe2+‐H2O2 degradation method. Physicochemical characterization showed that Fe2+‐H2O2 degradation could effectively decrease the molecular weight of FHRP, but did not significantly change chemical composition and monosaccharide composition. The functional assays indicated that DFHRP‐1 and DFHRR‐2 showed better oil‐holding, but weaker water‐holding and emulsifying capacities than FHRP. The results of bioactivity assays indicated that DFHRP‐1 and DFHRR‐2 exhibited better antioxidant, hypoglycemic, and immunostimulatory activities than FHRP. The functional and biological properties of the degraded polysaccharides from H. undatus flowers were greatly determined by its molecular weight. Overall, DFHRP‐1 and DFHRP‐2 might have potential applications as multi‐functional additives in foods, pharmaceuticals, and cosmetics. Practical applications It has been reported that degraded polysaccharides exhibited better water solubility, functional, and biological properties than native polysaccharide. In the present study, the degraded polysaccharides were obtained from the flowers of H. undatus by using the Fe2+‐H2O2 degradation method to modify its functional and biological properties. The results will provide valuable information for application of the degraded polysaccharides in the food industry.

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“…Splenocyte proliferation is a crucial event in the activation cascade of both cellular and humoral immune responses. Immunomodulatory effect of the PEPW80-1 was investigated, and the results showed that PEPW80-1 could significantly induce lymphocyte proliferation at a low concentration (25 μg/mL), which is greater than the polysaccharides from the swollen culms of Zizania latifolia (200 and 400 μg/mL) (44).…”

Section: Discussionmentioning

confidence: 99%

Structural characterization and biological activities of a novel polysaccharide from <i>Phyllanthus emblica </i>

Zeng

Lv²,

Jing³

et al. 2017

DD&T

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Characterization, antioxidant activity and immunomodulatory activity of polysaccharides from the swollen culms of Zizania latifolia

Cited by 134 publications

References 39 publications

Characterization, antioxidant, and anticancer activities of a neutral polysaccharide from Duchesnea indica (Andr.) Focke

Characterization, antioxidant, and anticancer activities of a neutral polysaccharide from Duchesnea indica (Andr.) Focke

Characterization, functional and biological properties of degraded polysaccharides from Hylocereus undatu s flowers

Structural characterization and biological activities of a novel polysaccharide from <i>Phyllanthus emblica </i>

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