Characterization, antimicrobial, antioxidant, and anticoagulant activities of silver nanoparticles synthesized from Petiveria alliacea L. leaf extract

Abstract

Phytosynthesis of silver nanoparticles (AgNPs) using leaf extract of Petiveria alliacea (PA) was the focus of this research work. The PA-AgNPs were characterized by UV-Vis spectroscopy, Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), and selected area electron diffraction (SAED) study. Studies were made on the AgNPs for antibacterial, antifungal, anticoagulant, free-radical scavenging, and hydrogen peroxide scavenging activities. The crystalline PA-AgNPs were monodispersed, with a size range of 16.70-33.74 nm and maximum absorption at 410 nm. FTIR analysis displayed prominent peaks at 3430.6, 1711.8, and 1165.9/cm, which showed the existence of phenolic compounds and proteins in the synthesis of AgNPs. PA-AgNPs was active against Escherichia coli, Klebsiella pneumoniae, and Staphylococcus aureus, with 100% inhibition. The PA-AgNPs also displayed good antifungal properties, as the concentrations of 100 and 150 µg/mL had 100% inhibition toward Aspergillus fumigatus and Aspergillus flavus. However, there was 66.67% inhibition of Aspergillus niger. It scavenged both DPPH and HO by 70.69 and 89.02%, respectively. PA-AgNPs also prevented the coagulation of human blood. This study, being the first of its kind to use the leaf extract of PA for the synthesis of AgNPs has shown that PA-AgNPs can find biomedical applications.

Silver‐gold alloy nanoparticles biofabricated by fungal xylanases exhibited potent biomedical and catalytic activities

“…The optical microscopic micrographs revealed the effective dispersion of disc‐like red blood cells due to reaction of blood clot with the biosynthesized Ag‐AuNPs. The results in this study are in line with some previous reports on the anticoagulant and thrombolytic potentials of Ag‐AuNPs, AgNPs, and AuNPs . Most recently, we documented a review on the applications of nanoparticles for the control and management of blood coagulation disorders …”

“…These attributes are very important in the management of blood coagulation disorders using nano-based products. 87 Ag-AuNPs, 5,13 AgNPs, 14,17,52,74,88 and AuNPs. 5,7 Most recently, we documented a review on the applications of nanoparticles for the control and management of blood coagulation disorders.…”

Eco-friendly synthesis of silver nanoparticles using leaf extract of Flemingia wightiana: spectral characterization, antioxidant and anticancer activity studies

“…Biological methods involve simple bioreduction methods and need not separate capping processes and separate capping agents. AgNPs have been prepared using different plant extracts including Gymnema sylvestre [36], Centella asiatica [37], Melia dubia [38], Rhynchosia suaveolens [39], Shorea roxburghii [40], Morus alba [41], Priva cordifolia [42], Catharanthus roseus [43], Andrographis paniculata [44], Cordia dichotoma [45], Cassia angustifolia [46], Amaranthus cruentus [47], Cola nitida [48], Arnebia hispidissima [49], Petiveria alliacea [50], Persea Americana [51], Buchanania axillaris [52], and Jatropha curcas [53] etc.…”

Green Nanotechnology in Nigeria: The Research Landscape, Challenges and Prospects

“…The synthesized AgNPs using the extracts of cobweb, pod, seed and seed shell of C. nitida achieved 77.0-99.8 % scavenging of H2O2. Similarly, Petiveria alliacea leaf extract-mediated AgNPs(Lateef et al, 2018b) were shown to scavenge H2O2 and DPPH by 89.02 and 70.69 %, respectively Elegbede et al (2018a). also reported xylanase-mediated AgNPs to have scavenged DPPH and H2O2 by 37.48-79.42 and 20.50-96.50 % respectively.…”