Characterization and Modeling of the Collision Induced Dissociation Patterns of Deprotonated Glycosphingolipids: Cleavage of the Glycosidic Bond

Rožman, Marko

doi:10.1007/s13361-015-1247-2

Cited by 5 publications

(1 citation statement)

References 24 publications

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“…Rožman (2016) has investigated the negative ion fragmentation of 75 gangliosides extracted from mice, calf, and human brain tissues and reported mainly glycosidic bond cleavages with major losses of sialic acids. The bond cleavage in both neutral and acidic glycosphingolipids was found to be the result of a charge‐directed intramolecular nucleophilic substitution (S N 2) mechanism.…”

Section: Studies On Specific Carbohydrate Typesmentioning

confidence: 99%

Analysis of Carbohydrates and Glycoconjugates by Matrix‐assisted Laser Desorption/Ionization Mass Spectrometry: An Update for 2015–2016

Harvey

2021

Mass Spectrometry Reviews

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This review is the ninth update of the original article published in 1999 on the application of matrix‐assisted laser desorption/ionization (MALDI) mass spectrometry to the analysis of carbohydrates and glycoconjugates and brings coverage of the literature to the end of 2016. Also included are papers that describe methods appropriate to analysis by MALDI, such as sample preparation techniques, even though the ionization method is not MALDI. Topics covered in the first part of the review include general aspects such as theory of the MALDI process, matrices, derivatization, MALDI imaging, fragmentation and arrays. The second part of the review is devoted to applications to various structural types such as oligo‐ and poly‐saccharides, glycoproteins, glycolipids, glycosides and biopharmaceuticals. Much of this material is presented in tabular form. The third part of the review covers medical and industrial applications of the technique, studies of enzyme reactions and applications to chemical synthesis. The reported work shows increasing use of combined new techniques such as ion mobility and the enormous impact that MALDI imaging is having. MALDI, although invented over 30 years ago is still an ideal technique for carbohydrate analysis and advancements in the technique and range of applications show no sign of deminishing. © 2020 Wiley Periodicals, Inc.

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Section: Studies On Specific Carbohydrate Typesmentioning

confidence: 99%