Characterization and Management of Inflammatory Eye Disease in Patients with Hidradenitis Suppurativa

Perforation in interstitial keratitis associated with hidradenitis suppurativa: medical and surgical management

“…Both her ocular symptoms and signs, and her dermatological condition, improved on immunosuppression, though episodic ocular inflammation did not cease entirely. Previously, remission of inflammatory eye disease associated with HS has been reported with adalimumab treatment, in 40%–50% of treated patients in two case series 6 19…”

“…A common dermatological problem with estimated prevalence of 1%,1 2 hidradenitis suppurativa (HS) has been observed to be associated with inflammatory eye disease, in particular peripheral ulcerative keratitis,3–7 but also interstitial keratitis,8 9 scleritis and uveitis 6 7. In one severe HS case, a middle-aged African American man developed Mooren’s type ulceration, which led to corneal perforation in one eye 5.…”

Peripheral ulcerative keratitis secondary to severe hidradenitis suppurativa

“…Hidradenitis suppurativa is a chronic follicular inflammatory skin disorder characterized by recurrent nodules, sinus tracts, abscesses, and scarring within primarily intertriginous regions. 1 , 2 , 3 Its pathogenesis is believed to be initial occlusion of the folliculopilosebaceous units of apocrine gland-bearing skin that subsequently rupture, prompting both an innate and adaptive immune response to the release of antigens and pro-inflammatory stimuli. 1 , 2 , 3 Coexistence of inflammatory eye disease and HS is rare.…”

“… 1 , 2 , 3 Its pathogenesis is believed to be initial occlusion of the folliculopilosebaceous units of apocrine gland-bearing skin that subsequently rupture, prompting both an innate and adaptive immune response to the release of antigens and pro-inflammatory stimuli. 1 , 2 , 3 Coexistence of inflammatory eye disease and HS is rare. In prior studies, the most common manifestation was anterior uveitis, followed by episcleritis/scleritis.…”

“…In prior studies, the most common manifestation was anterior uveitis, followed by episcleritis/scleritis. 2 , 3 Forms of keratitis that have been reported include interstitial keratitis, Mooren-type ulceration, and peripheral ulcerative keratitis. 4 , 5 , 6 , 7 Previous studies have also suggested topical corticosteroids as first-line treatment, however there is particular interest in anti -TNF agents given higher rate of remission for ocular inflammatory disease.…”