Characterization and identification of steroidal alkaloids in Fritillaria species using liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry

Zhou, Jian‐Liang; Xin, Gui-Zhong; Shi, Zi-Qi; Ren, Mei-Ting; Qi, Lian‐Wen; Li, Huijun; Li, Ping

doi:10.1016/j.chroma.2010.09.019

Cited by 90 publications

(54 citation statements)

References 27 publications

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“…The molecular phylogeny results are not congruent with those inferred from chemotaxonomy (Li et al, 2009a;Zhou et al, 2010). Many secondary metabolites have a taxonomically restricted distribution.…”

Section: Phylogenycontrasting

confidence: 69%

Phytochemical and biological research of Fritillaria medicinal resources

Hao¹

2015

Medicinal Plants

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Section: Phylogenycontrasting

confidence: 69%

Phytochemical and biological research of Fritillaria medicinal resources

Hao¹

2015

Medicinal Plants

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“…Some Fritillaria species have also been studied due to the anticholinesterase activity of their steroidal alkaloids. Usually, these compounds possess a C27 cholestane carbon skeleton, with five or six carbocyclic or heterocyclic rings . As for the other steroidal alkaloids, the Fritillaria alkaloids are more selective for BChE, with IC 50 values ranging from 0.7 to 121 μ m , chuanbeinone being the most active.…”

Section: Classes Of Anticholinesterase Alkaloidsmentioning

confidence: 99%

Alkaloids as a source of potential anticholinesterase inhibitors for the treatment of Alzheimer's disease

Konrath

Passos

Klein‐Júnior

et al. 2013

Journal of Pharmacy and Pharmacology

178

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Objectives The inhibition of acetylcholinesterase (AChE), the key enzyme in the breakdown of acetylcholine, is currently the main pharmacological strategy available for Alzheimer's disease (AD). In this sense, many alkaloids isolated from natural sources, such as physostigmine, have been long recognized as acetyl-and butyrylcholinesterase (BChE) inhibitors. Since the approval of galantamine for the treatment of AD patients, the search for new anticholinesterase alkaloids has escalated, leading to promising candidates such as huperzine A. This review aims to summarize recent advances in current knowledge on alkaloids as AChE and BChE inhibitors, highlighting structure-activity relationship (SAR) and docking studies. Key findings Natural alkaloids belonging to the steroidal/triterpenoidal, quinolizidine, isoquinoline and indole classes, mainly distributed within Buxaceae, Amaryllidaceae and Lycopodiaceae, are considered important sources of alkaloids with anti-enzymatic properties. Investigations into the possible SARs for some active compounds are based on molecular modelling studies, predicting the mode of interaction of the molecules with amino acid residues in the active site of the enzymes. Following this view, an increasing interest in achieving more potent and effective analogues makes alkaloids good chemical templates for the development of new cholinesterase inhibitors. Summary The anticholinesterase activity of alkaloids, together with their structural diversity and physicochemical properties, makes them good candidate agents for the treatment of AD.

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“…Based on the scaffold, FAs can be divided into cevanine, jervine, veratramine, solanidine, and secosolanidine types (Li, Jiang, & Li, ). The cevanine type which contains the hexacyclic benzofluorene quinolizine nucleus, comprised the typical skeleton of FAs (Atta‐ur‐Rahman et al ., , ; Oh, Kang, Lee, Li, & Lee, ; Jiang, Li, Li, Cai, & Ye, ; Zhou et al ., , ; Li, Jiang, & Li, ). Previous pharmacological studies demonstrated that FAs possess remarkable antitussive, expectorant, and anti‐asthmatic activities (Zhou, Ji, Li, & Jiang, ; Wang et al ., , ).…”

Section: Introductionmentioning

confidence: 99%