Characterization and evaluation of antibacterial and wound healing activity of naringenin-loaded polyethylene glycol/polycaprolactone electrospun nanofibers

Farzaei, Mohammad Hossein; Derayat, Pooneh; Pourmanouchehri, Zahra; Kahrarian, Mohsen; Samimi, Zeinab; Haji-Alyani, Marzieh; Bahrami, Gholamreza; Hosseinzadeh, Leila; Rashidi, Khodabakhsh; Tajehmiri, Ahmad; Behbood, Leila

doi:10.1016/j.jddst.2023.104182

Cited by 12 publications

(12 citation statements)

References 52 publications

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“…A total of 15 articles were selected after applying the inclusion criteria. Table 1 summarizes the flavonones loaded-nanocarriers for skin delivery, with emphasis to wound healing (11)(12)(13)(14)(15)(16) . Naringenin (11,12,(17)(18)(19)(20) and hesperidin (13)(14)(15)(16)21) were the most encapsulated flavanones.…”

Section: Resultsmentioning

confidence: 99%

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Citrus Flavonones into nanotechnology-based formulations to skin treatment

Scherer Santos,

Gonzatto

2023

Ars Pharm

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Introduction: Flavonones show potential application in the treatment of skin disorders, whose performance may be improved by using lipid and polymeric nanocarriers. In this review, a recent approach regarding nanocarriers containing either naringin, naringenin, hesperidin or hesperitin for skin application are discussed. Method: This review approaches the publications from the last 6 years about nanosystems containing Citrus flavonones for cutaneous applications. The articles were selected by searching in Scopus database for nanosystem containing either hesperidin, hesperitin, naringin or naringenin for cutaneous application, research articles written in English and published between 2018 and 2023, and reporting about skin penetration or biological evaluation. Results: Majority of reports employed lipid systems as nanocarriers. Naringenin was the most used flavonone. In relation to skin benefits, improved wound healing, atopic dermatitis treatment and stress oxidative-related diseases are highlighted. Despite the probable benefits, the development of plant-based nanomedicines is complex, which imposes limitations on the development of new pharmaceutical products. Further, the potential of flavonoids in the treatment of skin cancer has been shown. Conclusions: Lipid, polymeric and nanohybrid carriers are employed to deliver flavanones. Due to their antioxidant and anti-inflammatory activities, flavanones bear potential applications in the treatment of different skin disorders. Therefore, there is a promising application of flavanones to the improvement of human health, mainly with their loading into nanocarriers.

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Section: Resultsmentioning

confidence: 99%

“…Table 1 summarizes the flavonones loaded-nanocarriers for skin delivery, with emphasis to wound healing (11)(12)(13)(14)(15)(16) . Naringenin (11,12,(17)(18)(19)(20) and hesperidin (13)(14)(15)(16)21) were the most encapsulated flavanones. Regard to nanocarrier, lipid carriers (12,17,19,(22)(23)(24) are the most important ones.…”

Section: Resultsmentioning

confidence: 99%

Citrus Flavonones into nanotechnology-based formulations to skin treatment

Scherer Santos,

Gonzatto

2023

Ars Pharm

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“…Such grafts are usually synthetic biomaterial scaffolds, which may be based on polymers, − ceramics, − metals, , or composites, − as all of these have low risks of immunogenicity, and unlike autografts and allografts they are widely accessible. For instance, polycaprolactone (PCL) and polyethene glycol (PEG) are Food and Drug Administration (FDA) approved synthetic polymers with a proven history in biomedical applications, having favorable biocompatible and biodegradable properties, as well as being easily processed into desired shapes using additive manufacturing or electrospinning techniques. , PCL can be blended with PEG, leading to more favorable rheological and adhesive properties than PCL alone. , Furthermore, the incorporation of PEG into PCL provides greater thermoresistance of the scaffolds as well as enables prolonged, sustained, and controlled release of therapeutic molecules. , Altogether, this combination has resulted in an extensive application of the PCL–PEG blends in bone tissue engineering to mimic the extracellular matrix of the bone or to deliver osteogenic factors …”

Section: Introductionmentioning

confidence: 99%

Stimuli-Responsive Codelivery System-Embedded Polymeric Nanofibers with Synergistic Effects of Growth Factors and Low-Intensity Pulsed Ultrasound to Enhance Osteogenesis Properties

Malekmohammadi,

Jamshidi,

Sadowska

et al. 2024

ACS Appl. Bio Mater.

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The present work aims to develop optimized scaffolds for bone repair by incorporating mesoporous nanoparticles into them, thereby combining bioactive factors for cell growth and preventing rapid release or loss of effectiveness. We synthesized biocompatible and biodegradable scaffolds designed for the controlled codelivery of curcumin (CUR) and recombinant human bone morphogenic protein-2 (rhBMP-2). Active agents in dendritic silica/titania mesoporous nanoparticles (DSTNs) were incorporated at different weight percentages (0, 2, 5, 7, 9, and 10 wt %) into a matrix of polycaprolactone (PCL) and polyethylene glycol (PEG) nanofibers, forming the CUR-BMP-2@DSTNs/PCL−PEG delivery system (S0, S2, S5, S7, S9, and S10, respectively, with the number showing the weight percentage). To enhance the formation process, the system was treated using low-intensity pulsed ultrasound (LIPUS). Different advanced methods were employed to assess the physical, chemical, and mechanical characteristics of the fabricated scaffolds, all confirming that incorporating the nanoparticles improves their mechanical and structural properties. Their hydrophilicity increased by approximately 25%, leading to ca. 53% enhancement in their water absorption capacity. Furthermore, we observed a sustained release of approximately 97% for CUR and 70% for BMP-2 for the S7 (scaffold with 7 wt % DSTNs) over 28 days, which was further enhanced using ultrasound. In vitro studies demonstrated accelerated scaffold biodegradation, with the highest level observed in S7 scaffolds, approximately three times higher than the control group. Moreover, the cell viability and proliferation on DSTNs-containing scaffolds increased when compared to the control group. Overall, our study presents a promising nanocomposite scaffold design with notable improvements in structural, mechanical, and biological properties compared to the control group, along with controlled and sustained drug release capabilities. This makes the scaffold a compelling candidate for advanced bone tissue engineering and regenerative therapies.

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“…In addition, PCL has been widely used as a scaffold material for tissue engineering due to its biocompatibility, biodegradability, and mechanical properties. PCL scaffolds can be fabricated using a variety of techniques such as additive manufacturing [12,[18][19][20][24][25][26], electrospinning [22,[27][28][29][30], solvent casting [31,32], and melt extrusion [33][34][35] to create a range of structures with controlled pore size and mechanical strength. However, the stiffness of PCL is unfavorable for soft tissue scaffold applications such as cardiac, nerve, and muscle repair [36].…”

Section: Introductionmentioning

confidence: 99%

“…Melt blending is the most preferred method for mixing thermoplastics and has the highest relevance for industrial applications [37], including the production of medical devices [38][39][40][41], drug delivery [19][20][21]31,[39][40][41], scaffold [42][43][44], and tissue engineering [43][44][45][46], including the creation of aliphatic polyester blends for tissue engineering [29,47], drug delivery [15][16][17], and scaffolds [41]. In specific to melt blending production methods, hot melt extrusion (HME) has widespread acceptance not only in the production of many pharmaceutical products, but also in the production of implants and medical devices [48].…”

Section: Introductionmentioning

confidence: 99%

The Influence of the Molecular Weight of Poly(Ethylene Oxide) on the Hydrolytic Degradation and Physical Properties of Polycaprolactone Binary Blends

Dalton

Ebrahimi

et al. 2023

Macromol

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The use of biodegradable polymers in tissue engineering has been widely researched due to their ability to degrade and release their components in a controlled manner, allowing for the potential regeneration of tissues. Melt blending is a common method for controlling the degradation rate of these polymers, which involves combining these materials in a molten state to create a homogenous mixture with tailored properties. In this study, polycaprolactone (PCL) was melt blended with hydrophilic poly (ethylene oxide) (PEO) of different molecular weights to assess its effect on PCL material performance. Hydrolytic degradation, thermal and viscoelastic properties, and surface hydrophilicity were performed to contrast the properties of the blends. DSC, DMA, and FTIR were performed on selected degraded PCL/PEO specimens following mass loss studies. The results showed that adding PEO to PCL reduced its melt viscosity-torque and melt temperature while increasing its hydrophilicity, optimizing PCL/PEO blend for soft tissue engineering applications and could contribute to the development of more effective and biocompatible materials for soft tissue regeneration.

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Characterization and evaluation of antibacterial and wound healing activity of naringenin-loaded polyethylene glycol/polycaprolactone electrospun nanofibers

Cited by 12 publications

References 52 publications

Citrus Flavonones into nanotechnology-based formulations to skin treatment

Citrus Flavonones into nanotechnology-based formulations to skin treatment

Stimuli-Responsive Codelivery System-Embedded Polymeric Nanofibers with Synergistic Effects of Growth Factors and Low-Intensity Pulsed Ultrasound to Enhance Osteogenesis Properties

The Influence of the Molecular Weight of Poly(Ethylene Oxide) on the Hydrolytic Degradation and Physical Properties of Polycaprolactone Binary Blends

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