Characterization and dissolution–reprecipitation behavior of biphasic tricalcium phosphate powders

Zou, Chao; Cheng, Kui; Weng, Wenjian; Song, Chenlu; Du, Piyi; Shen, Ge; Han, Gaorong

doi:10.1016/j.jallcom.2011.03.158

Cited by 32 publications

(13 citation statements)

References 39 publications

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“…The results showed that different heat treatments of commercially available α‐TCP allowed the formation of biphasic TCP cement precursor powder with a variety of α/β‐TCP ratios. In a previous study, Zou et al and Li et al showed that biphasic α/β‐TCP particles can be prepared also by calcining an amorphous CaP precursor at a temperature ranging from 800 to 900°C. Similar to Zou et al, the current study also used SAED to confirm that both α‐ and β‐TCP polymorphs were present in single powder particles after heat treatment.…”

Section: Discussionmentioning

confidence: 99%

Injectable biphasic calcium phosphate cements as a potential bone substitute

et al. 2013

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Apatitic calcium phosphate cements (CPCs) have been widely used as bone grafts due to their excellent osteoconductive properties, but the degradation properties are insufficient to stimulate bone healing in large bone defects. A novel approach to overcome the lack of degradability of apatitic CPC involves the development of biphasic CPCs (BCPC) based on tricalcium phosphate (TCP) in both α- and β-polymorphs. The aim of the current study was to prepare and analyze the physicochemical properties of BCPCs based on dual phase α/β-TCP as obtained by heat treatment of pure α-TCP. The handling and mechanical characteristics of the samples as well as the degradation behavior under in vitro condition were investigated and compared with a standard monophasic α-TCP-based CPC. The results showed that different heat treatments of commercially available α-TCP allowed the formation of biphasic calcium phosphate powder with a variety of α/β-TCP ratios. The use of biphasic powder particles as a reactant for CPCs resulted into increased setting and injectability times of the final BCPCs. During hardening of the cements, the amount of apatite formation decreased with increasing β-TCP content in the biphasic precursor powders. The morphology of the monophasic CPC consisted of plate-like crystals, whereas needle-like crystals were observed for BCPCs. In vitro degradation tests demonstrated that dissolution rate and corresponding calcium release from the set cements increased considerably with increasing β-TCP content, suggesting that apatitic CPCs can be rendered degradable by using biphasic α/β-TCP as powder precursor phase.

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Section: Discussionmentioning

confidence: 99%

Injectable biphasic calcium phosphate cements as a potential bone substitute

et al. 2013

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“…Among them, the acetate buffer solution is free of these ions, and its use in acid pH range try to simulate an inflammatory process and at the same time reduce the tests periods due to an accelerating dissolution reaction 5,15 . Our aim was to study the effect of the simultaneous incorporation of magnesium and carbonate ions into the apatite lattice on the physico-chemical and dissolution properties of unsintered apatites obtained by aqueous precipitation.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous incorporation of magnesium and carbonate in apatite: effect on physico-chemical properties

et al. 2013

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Synthetic apatites are widely used both in the dental and the orthopaedic fields due to their similarity in composition with the inorganic phase of hard tissues. Biologic apatites are not pure hydroxyapatite (HA), but are calcium-deficient apatites with magnesium and carbonate as minor but important substituents. The aim of the present study was to produce a more soluble biomaterial through the simultaneous substitution of magnesium and carbonate in the apatite structure to accelerate the degradation time in the body. The physico-chemical and dissolution properties of unsintered magnesium and carbonate-substituted apatite (MCAp) with similar Mg/Ca molar ratio (0.03) and varying C/P molar ratio were evaluated. The resultant powders were characterised using several techniques, such as FTIR, TGA, XRD, ICP and SEM, while the release of calcium ions in a pH 6 solution was monitored using a Ca-ion selective electrode. The results showed a decrease of crystallite size and an increase in the release of calcium to the medium as the carbonate content in the samples increased.

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“…Mistura). The microcapsules remained in contact with the solutions for different times (12,24,48, 72 hours, 7 and 14 days). The experiments were performed in triplicate.…”

Section: Methodsmentioning

confidence: 99%

“…Different *e-mail: anapauladm@metalmat.ufrj.br buffer solutions are employed as soaking media in order to mimic the environment in which the biomaterial will be implanted. These buffers can simulate a neutral (simulating body fluid) or acidic pH 12 , corresponding to the inflammatory reactions that precede the osseointegration process.…”

Section: Introductionmentioning

confidence: 99%

Strontium Incorporation on Microspheres of Alginate/β-tricalcium Phosphate as Delivery Matrices

et al. 2014

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Strontium (Sr) is known to positively affect the mechanism of bone remodelling. Consequently, calcium phosphate bioceramics associated with alginate matrices containing strontium could improve bone regeneration due to gradual strontium release. This work aims to incorporate Sr on microspheres of alginate (ALG)/β-tricalcium phosphate (β-TCP) and evaluates the in vitro release of strontium ions into a buffer solution at pH 4.0 and 7.4. In this study, strontium chloride was employed as a cross-linking agent and Sr source. Energy dispersive spectroscopy (EDS) showed that strontium was incorporated mainly at the surface of the microspheres produced. The in vitro experiments revealed that there is a rapid strontium release up to 24 h at pH 7.4 due to Sr location on microspheres' surface. At pH 4.0 both calcium and strontium were released due to the β-TCP dissolution.

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Characterization and dissolution–reprecipitation behavior of biphasic tricalcium phosphate powders

Cited by 32 publications

References 39 publications

Injectable biphasic calcium phosphate cements as a potential bone substitute

Injectable biphasic calcium phosphate cements as a potential bone substitute

Simultaneous incorporation of magnesium and carbonate in apatite: effect on physico-chemical properties

Strontium Incorporation on Microspheres of Alginate/β-tricalcium Phosphate as Delivery Matrices

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