Characterization and biocompatibility evaluation of artificial blood vessels prepared from pristine poly (Ethylene-glycol-co-1,4-cyclohexane dimethylene-co-isosorbide terephthalate), poly (1, 4 cyclohexane di-methylene-co-isosorbide terephthalate) nanofibers and their blended composition

Fabrication of Poly(Ethylene-glycol 1,4-Cyclohexane Dimethylene-Isosorbide-Terephthalate) Electrospun Nanofiber Mats for Potential Infiltration of Fibroblast Cells

“…Recently, bio-based polyesters have been widely studied for biomedical applications such as cell culture, drug delivery, and wound dressing [1][2][3][4][5][6]. Scientists have started exploring the biomedical applications of isosorbide-based polyesters by virtue of their high tensile strength and good thermal stability [4,[6][7][8][9].…”

“…Recently, bio-based polyesters have been widely studied for biomedical applications such as cell culture, drug delivery, and wound dressing [1][2][3][4][5][6]. Scientists have started exploring the biomedical applications of isosorbide-based polyesters by virtue of their high tensile strength and good thermal stability [4,[6][7][8][9]. Electrospun nanofiber mats (ENMs), due to their high surface area, ease of production, fiber network interconnection, biocompatibility, breathability, and resemblance to natural extracellular matrix have been potentially considered for cell culture applications viz cell adhesion, cell migration, and cell viability [10][11][12][13].…”

“…In parallel, ENMs have been utilized in several applications including sensors [14], wound dressing [10], drug delivery [5], tissue engineering [15], smart apparels [16,17] high performance filters (water, bacteria, virus, heavy metal, and such impurities) [18][19][20][21]. Depending on the required application, cell adhesion and cell migration behaviors may differ due to the difference in cell size, type, or the culturing surface [4,6]. Scaffolds based on ENMs possess good biodegradability, biocompatibility, non-thrombogenicity, and non-immunogenicity, however, the optimization of such materials is challenging in terms of cell viability, cell infiltration, cell adhesion, and migration properties [4][5][6]10,11,22].…”

“…Depending on the required application, cell adhesion and cell migration behaviors may differ due to the difference in cell size, type, or the culturing surface [4,6]. Scaffolds based on ENMs possess good biodegradability, biocompatibility, non-thrombogenicity, and non-immunogenicity, however, the optimization of such materials is challenging in terms of cell viability, cell infiltration, cell adhesion, and migration properties [4][5][6]10,11,22].…”

“…Poly(ethylene-glycol 1,4-Cyclohexane dimethylene-isosorbide-terephthalate) (PEICT) ENMs, in light of their high glass transition temperature [23], good mechanical properties [8], flexibility [6], thermal stability [4], and good crystallinity [23] have potentially been studied for various biomedical applications [4,6].…”