Characterization and autoradiographic distribution of vasoactive intestinal peptide binding sites in the rat central nervous system

Besson, J.; Sarrieau, Alain; Vial, Micheline; Marie, Jean‐Claude; Rosselin, G; Rostène, William

doi:10.1016/0006-8993(86)91493-9

Cited by 83 publications

(32 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The vasoactive intestinal peptide (VIP) is an essential neuropeptide widely distributed in the peripheral and central nervous systems [135] , with a large spectrum of biological actions in mammals, including hormonal regulation, analgesia, neurotrophic and mediation of circadian rhythmicity [136] . In the hippocampus, VIP is expressed only in the interneurons [137] .…”

Section: Vasoactive Intestinal Peptidementioning

confidence: 99%

Roles of the hippocampal formation in pain information processing

2009

View full text Add to dashboard Cite

Abstract:Pain is a complex experience consisting of sensory-discriminative, affective-motivational, and cognitive-evaluative dimensions. Now it has been gradually known that noxious information is processed by a widely-distributed, hierarchicallyinterconnected neural network, referred to as neuromatrix, in the brain. Thus, identifying the multiple neural networks subserving these functional aspects and harnessing this knowledge to manipulate the pain response in new and beneficial ways are challenging tasks. Albeit with elaborate research efforts on the cortical responses to painful stimuli or clinical pain, involvement of the hippocampal formation (HF) in pain is still a matter of controversy. Here, we integrate previous animal and human studies from the viewpoint of HF and pain, sequentially representing anatomical, behavioral, electrophysiological, molecular/ biochemical and functional imaging evidence supporting the role of HF in pain processing. At last, we further expound on the relationship between pain and memory and present some unresolved issues.

show abstract

Section: Vasoactive Intestinal Peptidementioning

confidence: 99%

Roles of the hippocampal formation in pain information processing

2009

View full text Add to dashboard Cite

show abstract

“…This receptor is present in lung, liver and intestine, as well as several regions of the brain (e.g. cerebral cortex and hippocampus [5,6]) which contain high densities of specific binding sites for VIE Here we report the cloning and expression of a second, high affinity, VIP receptor. The receptor was identified by PCR of rat pituitary cDNA using degenerate oligonucleotide primers corresponding to the third and seventh transmembrane domains of the secretin/calcitonin/parathyroid hormone family of G protein-linked receptors.…”

Section: Introductionmentioning

confidence: 95%

“…VIP has a number of actions in the periphery, including vasodilatation, stimulation of electrolyte secretion and smooth muscle relaxation [4]. The presence of specific VIP binding sites in defined pathways in the brain indicates that it may play an important role in CNS function [5,6]. VIP may also regulate cerebral energy metabolism [7] and neuronal survival [8].…”

Section: Introductionmentioning

confidence: 99%

The VIP₂ receptor: Molecular characterisation of a cDNA encoding a novel receptor for vasoactive intestinal peptide

Lutz¹,

Sheward²,

Km³

et al. 1993

FEBS Letters

469

270

View full text Add to dashboard Cite

We have cloned and sequenced a cDNA (RPR4) encoding a new member of the secretin/calcitonin/parathyroid hormone (PTH) receptor family. RPR4 was identified by PCR of rat pituitary cDNA, and a full-length clone was isolated from a rat olfactory bulb cDNA library. When RPR4 was functionally expressed in COS 7 cells, cyclic adenosine monophosphate (cAMP) production was stimulated by vasoactive intestinal peptide (VIP), pituitary adenylate cyclase activating peptides (PACAP-38 and PACAP-27) and helodermin, with equal potency. Peptide histidine isoleucine (PHI) and rat growth hormone releasing hormone (rGHRH) also stimulated cAMP production at lower potency. This suggests that RPR4 encodes a novel VIP receptor which we have designated the VIP 2 receptor. In situ hybridisation showed that mRNA for this receptor was present mainly in the thalamus, hippocampus and in the suprachiasmatic nucleus.Vasoactive intestinal peptide (VIP); G protein-linked receptor; Rat pituitary; Rat olfactory bulb; cDNA cloning

show abstract

“…VIP is widely expressed in both the peripheral and central nervous systems. It exerts a variety of physiological effects on the circulation (Gozes & Brenneman 1989), gastrointestinal function (Said 1982), the immune system (Ottaway 1987, Ishioka et al 1992, reproduction (El-Gehani et al 1998) and the central nervous system (Besson et al 1986, Martin et al 1987. There is recent evidence indicating that VIP also plays an important role in the perception of pain (Dickinson & Fleetwood-Walker 1999) and suppression of inflammation (Said 1998).…”

Section: Introductionmentioning

confidence: 99%

Structural and functional identification of the pituitary adenylate cyclase-activating polypeptide receptor VPAC2 from the frog Rana tigrina rugulosa

Hoo

Dionne‐Laporte²,

Chan³

et al. 2001

Journal of Molecular Endocrinology

View full text Add to dashboard Cite

Recently, a frog pituitary adenylate cyclaseactivating polypeptide (PACAP)/vasoactive intestinal peptide (VIP) receptor (fPVR) has been characterized, and interestingly, this receptor exhibits characteristics of both mammalian PACAP type II receptors VPAC 1 R and VPAC 2 R. In order to investigate the receptors responsible for mediating the actions of VIP and PACAP in amphibians, in this report, a frog VPAC 2 receptor (fVPAC 2 R) cDNA was isolated. fVPAC 2 R shares 47·7, 46·9 and 62·5% amino acid sequence identity with fPVR, human VPAC 1 R and human VPAC 2 R respectively. Functionally, fVPAC 2 R, when expressed in CHO cells, was responsive to both frog peptides including VIP, PACAP38 and PACAP27 where the EC 50 values of these peptides in intracellular cAMP production were 0·15, 0·18 and 0·16 µM respectively. The pharmacological profiles of human peptides (VIP, PACAP38 and peptide histidine methionine) to stimulate frog and human VPAC 2 Rs were compared, and it was found that these peptides could only activate the frog receptor at micromolar concentrations. fVPAC 2 R was found to be widely distributed in various peripheral tissues as well as several regions of the brain. The presence of the receptor transcripts suggests the functional roles of the receptor in mediating the actions of PACAP and/or VIP in these tissues. As VIP and particularly PACAP27 are highly conserved peptides in vertebrate evolution, comparative studies of these peptides and their receptors in non-mammalian vertebrates should provide clues to better understand the physiology of these important peptides in human and other vertebrates.

show abstract

Characterization and autoradiographic distribution of vasoactive intestinal peptide binding sites in the rat central nervous system

Cited by 83 publications

References 43 publications

Roles of the hippocampal formation in pain information processing

Roles of the hippocampal formation in pain information processing

The VIP₂ receptor: Molecular characterisation of a cDNA encoding a novel receptor for vasoactive intestinal peptide

Structural and functional identification of the pituitary adenylate cyclase-activating polypeptide receptor VPAC2 from the frog Rana tigrina rugulosa

Contact Info

Product

Resources

About

Characterization and autoradiographic distribution of vasoactive intestinal peptide binding sites in the rat central nervous system

Cited by 83 publications

References 43 publications

Roles of the hippocampal formation in pain information processing

Roles of the hippocampal formation in pain information processing

The VIP2 receptor: Molecular characterisation of a cDNA encoding a novel receptor for vasoactive intestinal peptide

Structural and functional identification of the pituitary adenylate cyclase-activating polypeptide receptor VPAC2 from the frog Rana tigrina rugulosa

Contact Info

Product

Resources

About

The VIP₂ receptor: Molecular characterisation of a cDNA encoding a novel receptor for vasoactive intestinal peptide