Characterization and antiinflammatory properties of fractionated pyroligneous acid from palm kernel shell

Rabiu, Zainab; Hamzah, Mohd Amir Asyraf Mohd; Hasham, Rosnani; Zakaria, Zainul Akmar

doi:10.1007/s11356-020-09209-x

Cited by 15 publications

(11 citation statements)

References 38 publications

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“…Three major components identified were 2,6-dimethoxyphenol (syringol) with a percentage of 29.54%, 2-methoxyphenol (guaiacol), with a percentage of 12.36%, and 3,5dimethoxy-4-hydroxytoluene with a percentage of 11.07%, respectively. Even though the AC is obtained from a pyrolysis of different plant sources, the results shown by Rabiu et al (2020) is similar with the one reported by Yang et al (2016) as PKS contains high percentage of phenolic compounds such as phenol and 2-methoxyphenol (guaiacol).…”

Section: Analysis Of Interaction Between Enzymes With Phenolic Compoundssupporting

confidence: 79%

Molecular docking analysis on antifungal properties of acid condensate produced from palm kernel shell

Azman

Hamzah

Yahayu

et al. 2022

Environmental Quality Mgmt

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The rise in the number of fungi that resisted antifungal action is of serious concern nowadays. In this study, the potential of acid condensate (AC) produced from microwave‐assisted pyrolysis of palm kernel shell (PKS) was investigated for its antifungal properties through molecular docking evaluation. The phenolic‐rich AC was determined for its chemical compositions using the GC–MS analysis where compounds with the highest phenolics content were further evaluated (using the Autodock Tools 1.5.7) for its potential enzymes/protein binding properties. From the GC–MS analysis, catechol, guaiacol and syringol were present at highest percentages. This directly correlates with results obtained from the molecular docking works where all these ligands managed to bind (indicated by H‐bond, π‐stacking, hydrophobic interaction) with some of the amino acid at the active sites which indicate its potential to inhibit substrate binding of this enzyme. As a conclusion, this study demonstrated the potential use of AC from agricultural biomass such as PKS as a natural‐based antifungal agent that can reduce environmental and health impacts.

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Section: Analysis Of Interaction Between Enzymes With Phenolic Compoundssupporting

confidence: 79%

Molecular docking analysis on antifungal properties of acid condensate produced from palm kernel shell

Azman

Hamzah

Yahayu

et al. 2022

Environmental Quality Mgmt

View full text Add to dashboard Cite

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“…For instance, leaf extracts from Thymus algeriensis and Thymus fontanessi from Algeria exhibited IC 50 of 12.4 and 0.05 µg/mL on COX-1 and COX-2, respectively, and their activities were attributed to the presence of several phenolic acids, among them phloretic acid (identified in the tested extract) and apigenin, luteolin and quercetin glucosides (identified in the studied extract) [ 3 ]. Another study demonstrated that several fractions of pyroligneous acid obtained from palm kernel shell, rich in p -hydroxybenzoic acid (a major compound in our extract) exhibited substantial COX-1, COX-2 and LOX inhibitory activities [ 21 ]. Iridoid glucosides are widely distributed in aromatic and medicinal plants and act as prodrugs [ 22 ].…”

Section: Resultsmentioning

confidence: 99%

Anti-Inflammatory, Antipyretic, and Analgesic Properties of Potamogeton perfoliatus Extract: In Vitro and In Vivo Study

et al. 2021

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Natural antioxidants, especially those of plant origins, have shown a plethora of biological activities with substantial economic value, as they can be extracted from agro-wastes and/or under exploited plant species. The perennial hydrophyte, Potamogeton perfoliatus, has been used traditionally to treat several health disorders; however, little is known about its biological and its medicinal effects. Here, we used an integrated in vitro and in vivo framework to examine the potential effect of P. perfoliatus on oxidative stress, nociception, inflammatory models, and brewer’s yeast-induced pyrexia in mice. Our results suggested a consistent in vitro inhibition of three enzymes, namely 5-lipoxygenase, cyclooxygenases 1 and 2 (COX-1 and COX-2), as well as a potent antioxidant effect. These results were confirmed in vivo where the studied extract attenuated carrageenan-induced paw edema, carrageenan-induced leukocyte migration into the peritoneal cavity by 25, 44 and 64% at 200, 400 and 600 mg/kg, p.o., respectively. Moreover, the extract decreased acetic acid-induced vascular permeability by 45% at 600 mg/kg, p.o., and chemical hyperalgesia in mice by 86% by 400 mg/kg, p.o., in acetic acid-induced writhing assay. The extract (400 mg/kg) showed a longer response latency at the 3 h time point (2.5 fold of the control) similar to the nalbuphine, the standard opioid analgesic. Additionally, pronounced antipyretic effects were observed at 600 mg/kg, comparable to paracetamol. Using LC-MS/MS, we identified 15 secondary metabolites that most likely contributed to the obtained biological activities. Altogether, our findings indicate that P. perfoliatus has anti-inflammatory, antioxidant, analgesic and antipyretic effects, thus supporting its traditional use and promoting its valorization as a potential candidate in treating oxidative stress-associated diseases.

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“…The biodegradable antibacterial, antifungal, antioxidant and antiinflammatory properties of PKS have been established due to its high phenolic content when pyrolyzed (Sundalian et al, 2021). Practically, several studies obtained pyroligneous acid from pyrolyzed PKS while fumes from pyrolyzed PKS and empty fruit bunches were condensed into liquid smoke in (Rabiu et al, 2020;Mahmud et al, 2019;Sulong et al, 2020;Ni'mah et al, 2019). Optimal conditions of 375 g PKS with 125 g empty bunches had a yield of 266 ml of liquid smoke at 500 • C. Due to the high phenol content of the fractionated pyroligneous acid or liquified smoke, the products were recommended as a fungicide, antioxidant, and bactericide for nitric oxide inhibition and against odor development in latex.…”

Section: Biotechnological Applications Of Pksmentioning

confidence: 99%

Potentials of palm kernel shell derivatives: a critical review on waste recovery for environmental sustainability

2022

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Characterization and antiinflammatory properties of fractionated pyroligneous acid from palm kernel shell

Cited by 15 publications

References 38 publications

Molecular docking analysis on antifungal properties of acid condensate produced from palm kernel shell

Molecular docking analysis on antifungal properties of acid condensate produced from palm kernel shell

Anti-Inflammatory, Antipyretic, and Analgesic Properties of Potamogeton perfoliatus Extract: In Vitro and In Vivo Study

Potentials of palm kernel shell derivatives: a critical review on waste recovery for environmental sustainability

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