Characterization and Anti-Microbial Susceptibility of Gram-Negative Bacteria Isolated From Bloodstream Infections of Cancer Patients on Chemotherapy in Pakistan

Saghir, Sultan Ayesh Mohammed; Faiz, Mariam; Saleem, Mohammad; Younus, A; Aziz, H. M.

doi:10.4103/0255-0857.55454

Cited by 24 publications

(25 citation statements)

References 18 publications

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“…These findings for E. coli and Klebsiella spp. were consistent with the studies done by Saghir et al [2009] and Fayyaz et al [2013] who reported 28% and 22.44%, respectively, sensitivity to Enterobacteriacae family. However, the findings of Citrobacter spp.…”

Section: Antibioticsupporting

confidence: 93%

Bloodstream infections and antimicrobial sensitivity patterns in a tertiary care hospital of India

Vasudeva

Nirwan

Shrivastava

2016

Therapeutic Advances in Infection

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Background: Invasion of the bloodstream by microorganisms constitutes one of the most serious situations in infectious disease. Microorganisms present in circulating blood whether continuously, intermittently, or transiently are a threat to every organ in the body. Prevalence and antimicrobial susceptibility of microorganisms vary depending upon the geography and the use of antibiotics. Methods: A cross-sectional study to determine the prevalent organisms causing bloodstream infection was conducted. BACTEC BD 9050 system was used to identify the causative organism, and sub-cultures were done on MacConkey Agar and Blood Agar. Antibiotic susceptibility test (AST) was done using Kirby B Disk diffusion method. Results: A total of 170 patients were enrolled, and blood samples of 53 patients showed growth of organisms. Staphylococcus aureus was the most commonly isolated organism. Most of the Gram-positive cocci (GPC) were susceptible to vancomycin and linezolid. Most of the Gram-negative bacilli (GNB) showed sensitivity to cefoperazone/sulbactam followed by imipenem.

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Section: Antibioticsupporting

confidence: 93%

Bloodstream infections and antimicrobial sensitivity patterns in a tertiary care hospital of India

Vasudeva

Nirwan

Shrivastava

2016

Therapeutic Advances in Infection

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“…In his study, E. coli led the list of pathogens. In our study, 4.4% of the total gram-negative isolated bacteria were E. coli followed by Yersinia enterocolitica(4.4%) which is similar to a study by Saghir, 2009 10 . Previous studies have shown the presence of some multi drug resistant bacterial species among cancer patients.…”

Section: Discussionsupporting

confidence: 91%

Isolation of Multidrug Resistant Bacteria from Aspirates of Cancer Patients

Ahsan

Mahmud²,

Ahsan

et al. 2019

Bangla. J. Microbiol.

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Infections due to Gram-negative bacteria are common affairs in cancer patients during aggressive therapy. The present study characterizedmulti-drug resistant bacteria (MDR) isolated from cancer aspirates collected from patients admitted to the National Cancer Hospital in Dhaka, Bangladesh. A total of 210 aspirate samples were collected from cancer patients. Out of 210 samples Acinetobacter spp.led the list of isolates (8.89%, n=45). Of these species, 50% exhibited resistance to Amoxycillin and Nitrofurantoin, each, 25% exhibited resistant to Cefotaxime, Azithromycin, Ciprofloxacin, Clindamycin, and Sulfamethoxazole. A total of 33.33% of the Bordetella spp.which accounted 6.67%of the total isolates exhibited resistance to Cefotaxime. All oftheLegionellapneumophila,comprising 4.4%of the isolated species, wereresistant to Cefotaxime, Azithromycin, and Clindamycin.In contrast, 50% were resistant to Cefotaxime, Azithromycin, and Ceftriaxone. Of the Escherichia coli(4.4%, n=45) isolated,50% exhibited resistance to Cefotaxime, Clindamycin, Ceftriaxone, Amoxycillinand Sulfamethoxazole.The only isolate of Klebsiella sp. was demonstrated to be an ESBL producer. The isolation of multidrug resistant bacteria from cancer patients is of particular concern in Bangladesh where cancer and drug resistance are both common phenomena but treatment facilities are poor. To our knowledge this is the first report of the isolation of drug resistant bacteria from cancer patients from Dhaka city. Bangladesh J Microbiol, Volume 35 Number 1 June 2018, pp 61-66

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“…4 However, other studies have reported a lower resistance proportion for ceftriaxone. 30 , 37 , 38 This high resistance rate in our study could have been due to the fact that these antibiotics have already been in use for empirical therapy of patients with cancer in our setting. The higher resistance rate for ceftriaxone is an important issue, as this antibiotic has been commonly used to treat critically ill patients in our country.…”

Section: Discussionmentioning

confidence: 86%

Microbial spectrum and drug-resistance profile of isolates causing bloodstream infections in febrile cancer patients at a referral hospital in Addis Ababa, Ethiopia

Arega¹,

Woldeamanuel²,

Adane³

et al. 2018

IDR

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BackgroundThe spectrum of pathogens causing bloodstream infections (BSIs) in cancer patients has shown significant fluctuations in different geographical areas and time. We studied the microbial spectrum and drug-resistance profile of pathogens causing BSIs in febrile cancer patients at a referral hospital in Ethiopia.MethodsThis cross-sectional study was conducted between December 2011 and June 2012 at Tikur Anbessa Hospital in Addis Ababa. Blood cultures from febrile cancer patients (n=107) were performed. Bacterial and fungal pathogens were identified and antimicrobial susceptibility testing done for the bacterial isolates using the Kirby–Bauer disk diffusion method.ResultsA total of 82 pathogens were isolated from 112 blood culture tests of the 76 patients: 71 (86.6%) of the isolates were bacteria and 11 (13.4%) were fungi. The majority (60.5% [43 of 71]) of the isolates were Gram-positive bacteria, where Staphylococcus aureus was predominant (72% [31 of 43]), and 68% of S. aureus isolates were resistant to ceftriaxone and oxacillin. Gram-negative bacteria accounted for 39.5% (28 of 71) of the isolates. Stenotrophomonas maltophilia (17.9% [five of 28]) was the most frequent Gram-negative isolate. In Gram-negative bacteria, the highest rates of resistance were observed in amoxicillin–clavulanic acid (80% [12 of 15]), followed by ceftriaxone (73.3%) and trimethoprim–sulfamethoxazole (73.3%). Multidrug resistance (resistance to three or more types of antibiotics, in this case to ceftriaxone, tetracycline, and trimethoprim-sulfamethoxazole) was observed in 26.3% (13 of 43) of Gram-positive and 40% (six of 16) of Gram-negative bacteria. Neutropenia was an independent risk factor for BSIs (P=0.02).ConclusionGram-positive bacteria were the predominant etiologic agents of BSIs in Ethiopian patients with cancer. Both Gram-positive and Gram-negative bacteria showed an increasing level of resistance for most of the antibiotics used for empiric therapy. Routine bacterial surveillance and study of their resistance patterns must be an essential component of cancer-related infection control and care in our setting.

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Characterization and Anti-Microbial Susceptibility of Gram-Negative Bacteria Isolated From Bloodstream Infections of Cancer Patients on Chemotherapy in Pakistan

Cited by 24 publications

References 18 publications

Bloodstream infections and antimicrobial sensitivity patterns in a tertiary care hospital of India

Bloodstream infections and antimicrobial sensitivity patterns in a tertiary care hospital of India

Isolation of Multidrug Resistant Bacteria from Aspirates of Cancer Patients

Microbial spectrum and drug-resistance profile of isolates causing bloodstream infections in febrile cancer patients at a referral hospital in Addis Ababa, Ethiopia

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