Characteristics, Stability and Activity of Epigallocatechin Gallate (EGCG)-Chitosan Microspheres: Effect of Polymer Concentration

Rosita, Noorma; Nailufa, Yuyun; Hariyadi, Dewi Melani

doi:10.5958/0974-360x.2020.00415.1

Cited by 4 publications

(2 citation statements)

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“…However, EGCG has low lipophilicity, is easily degraded at high temperatures, and demonstrates low tissue permeability (10).Moreover, it lacks high bioavailability for oral preparations because it can be degraded by the metabolism of digestive bacteria (11). It has previously been reported that the concentration of EGCG decreases at 50°C during storage periods (12). However, although degraded at pH 6.8, it remains stable at pH 4.5 (13).…”

Section: Introductionmentioning

confidence: 99%

Intravaginal delivery of reverse micellar epigallocatechin loaded in ĸ-carrageenan and HPMC K100M-based gel

ROSİTA,

HARIYADİ,

AMELİA

et al. 2022

jrp

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A gel with mucoadhesive properties and a controlled release profile is a suitable dosage form for reverse micellar EGCG delivery. In this study, ĸ-Carrageenan and HPMC K100M were used as the gel components at a weight ratio of 1:1.5, respectively, for loading native and reverse micellar EGCG. The characteristics of the gel were determined based on pH, swelling index, disintegration time, hardness, and entrapment efficiency. The in vitro EGCG release rate was further determined for EGCG levels. Moreover, in vivo cervical penetration studies of rhodamine-labeled EGCG gels in mice at two and six hours after intravaginal administrations were conducted. The results showed that the pH and hardness characteristics of the gels for each formula did not differ significantly, while the gel-loaded reverse micellar EGCG had a higher swelling index than that of native EGCG gels. In addition, the rate of release and cervical penetration of rhodamine-labeled reverse micellar EGCG loaded in gels was higher than those of rhodamine-labeled native EGCG gels. Therefore, it can be concluded that loading reverse micelles EGCG into gels prepared with ĸ-Carrageenan and HPMC K100M successfully controlled the release rate and improved cervical penetration, thereby enabling its potential use in cervical cancer treatment.

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Section: Introductionmentioning

confidence: 99%

Intravaginal delivery of reverse micellar epigallocatechin loaded in ĸ-carrageenan and HPMC K100M-based gel

ROSİTA,

HARIYADİ,

AMELİA

et al. 2022

jrp

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show abstract

“…It happened by inhibiting inflammatory leukocyte infiltration and production of prostaglandin metabolites, which were used to protect against suninduced suppression of the skin immune system and prevent skin photoaging by reducing matrix expression metalloproteinases triggered by solar UV radiation (Scalia et al, 2014). EGCG has several limitations, namely easy oxidation (photodegradation) and hydrophilic properties so that penetration in the skin is low (log P 1.1) (Avadhani et al, 2017;Rosita et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Characteristic and Physical Stability of Anti-Aging Green Tea Extract (GTE) on NLC with Argan Oil as Liquid Lipid

Suryawijaya

Purwanti

Purwanto

et al. 2022

JFIKI

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Background: Green tea extract is a hydrophilic antioxidant that is difficult to penetrate. A nanostructured lipid carrier (NLC) delivers a system consisting of solid-liquid lipids that can improve penetration. Argan oil is a vegetable oil that can be used as a liquid lipid in NLC, reducing particle size and increasing penetration by hydrating the skin. Objective: To determine the formula of NLC green tea extract (NLC-GTE) with liquid lipid argan oil, which has good characteristics and is stable. Methods: Preparation of NLC-GTE used the High Shear Homogenization with solid lipids (cetyl palmitate-glyceryl stearate) - liquid lipids (argan oil) NLC-GTE1 (50:50), NLC-GTE2 (70:30), and NLC-GTE3 (90:10). Characteristic tests included organoleptic, pH, particle size (PS), and polydispersity index (PI). The physical stability test (organoleptic, pH, PS, and PI) used the thermal cycling method (3 cycles six days). Result: NLC-GTE1 – NLC-GTE2 has an odor of argan oil. NLC-GTE3 has odorless. NLC-GTE1 – NLC-GTE3 has a pH scale from 5.782-5.784; PS ranges from 359.73–432.56 nm; PI ranges from 0.175-0.257. The statistical analysis results showed no significant difference between NLC-GTE1 – NLC-GTE3 in pH and PI, there was a significant difference in PS NLC-GTE1; NLC-GTE2 against NLC-GTE3. Physical stability test NLC-GTE2 – NLC-GTE3 phase separation occurs. The statistical analysis results showed no significant difference in pH values NLC-GTE1 – NLC-GTE3 before and after storage; there was a significant difference in NLC-GTE3 before and after storage. Conclusion: NLC-GTE1 was a formula with good characteristics and stability.

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Microsponge as a Strategy for Effective Drug Delivery System

Yousif

Salman²

2023

AJPS

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The technology of drug delivery has become massively competitive and quickly growing. Enhancing efficacy is the primary objective of delivery system development, and hence cost-effectiveness of the treatment. Nevertheless, controlling the rate of delivery of active pharmaceutical moieties to a target site within the body has been one of the major obstacles confronted by the drug industry. Microsponge represents a delivery system considered a promising innovation that overcomes the different challenges, since, this dosage form provides the delivery of active pharmaceutical moieties in a timely manner, in addition to responding to different stimuli (pressure, temperature, pH). Microsponge drug delivery technology proposed capturing of active moieties into tiny spongy spheres thus, donating towards reducing side effects, improving stability, increasing elegance, and enhancing formulation flexibility. The goal behind this contribution is to cover microsponge as a successful innovation, summarizing the characteristics, advantages, and limitations with certain insight into the mechanism and factors triggering the release. Furthermore, shed light on the methodology of preparation.

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Characteristics, Stability and Activity of Epigallocatechin Gallate (EGCG)-Chitosan Microspheres: Effect of Polymer Concentration

Cited by 4 publications

References 0 publications

Intravaginal delivery of reverse micellar epigallocatechin loaded in ĸ-carrageenan and HPMC K100M-based gel

Intravaginal delivery of reverse micellar epigallocatechin loaded in ĸ-carrageenan and HPMC K100M-based gel

Characteristic and Physical Stability of Anti-Aging Green Tea Extract (GTE) on NLC with Argan Oil as Liquid Lipid

Microsponge as a Strategy for Effective Drug Delivery System

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