Characteristics of Virulent ST5-SCCmec II Methicillin-Resistant Staphylococcus aureus Prevalent in a Surgery Ward
Lei Huang,
Chengcheng Liu,
Zhanjie Li
et al.
Abstract:Objective
To investigate the transmission pathway of a MRSA prevalence in a pancreatic surgery ward in a Chinese teaching hospital.
Methods
Molecular epidemiology investigations were carried out combined PFGE, MLST, SCC
mec
typing and whole-genome sequencing for 20 successive MRSA isolates (2 isolates from the ward environment). Resistance and virulence genes were detected using specific PCR. Bacterial identification and AST were performed usi… Show more
“…This also instigates that the hospital environment and lack of proper hand hygiene could be risk factors for AMR spread. 41 Figure 4 Schematic flow of antibiotic resistance from hotspots of evolution. Reprinted from Kraemer SA, Ramachandran A, Perron GG.…”
Section: Potential Causes Of the Spread Of Antimicrobial Resistance F...mentioning
confidence: 99%
“…This also instigates that the hospital environment and lack of proper hand hygiene could be risk factors for AMR spread. 41 Beyond this, after being discharged into the environment, resistant bacteria can reside on plants and be ingested by animals (Figure 4). Once inside the animals' gut, they transfer the resistant gene, which then alters the structure of the microbiome community since gut contains different microorganisms.…”
Antimicrobial resistance, referring to microorganisms’ capability to subsist and proliferate even when there are antimicrobials is a foremost threat to public health globally. The appearance of antimicrobial resistance can be ascribed to anthropological, animal, and environmental factors. Human-related causes include antimicrobial overuse and misuse in medicine, antibiotic-containing cosmetics and biocides utilization, and inadequate sanitation and hygiene in public settings. Prophylactic and therapeutic antimicrobial misuse and overuse, using antimicrobials as feed additives, microbes resistant to antibiotics and resistance genes in animal excreta, and antimicrobial residue found in animal-origin food and excreta are animals related contributive factors for the antibiotic resistance emergence and spread. Environmental factors including naturally existing resistance genes, improper disposal of unused antimicrobials, contamination from waste in public settings, animal farms, and pharmaceutical industries, and the use of agricultural and sanitation chemicals facilitatet its emergence and spread. Wildlife has a plausible role in the antimicrobial resistance spread. Adopting a one-health approach involving using antimicrobials properly in animals and humans, improving sanitation in public spaces and farms, and implementing coordinated governmental regulations is crucial for combating antimicrobial resistance. Collaborative and cooperative involvement of stakeholders in public, veterinary and ecological health sectors is foremost to circumvent the problem effectively.
“…This also instigates that the hospital environment and lack of proper hand hygiene could be risk factors for AMR spread. 41 Figure 4 Schematic flow of antibiotic resistance from hotspots of evolution. Reprinted from Kraemer SA, Ramachandran A, Perron GG.…”
Section: Potential Causes Of the Spread Of Antimicrobial Resistance F...mentioning
confidence: 99%
“…This also instigates that the hospital environment and lack of proper hand hygiene could be risk factors for AMR spread. 41 Beyond this, after being discharged into the environment, resistant bacteria can reside on plants and be ingested by animals (Figure 4). Once inside the animals' gut, they transfer the resistant gene, which then alters the structure of the microbiome community since gut contains different microorganisms.…”
Antimicrobial resistance, referring to microorganisms’ capability to subsist and proliferate even when there are antimicrobials is a foremost threat to public health globally. The appearance of antimicrobial resistance can be ascribed to anthropological, animal, and environmental factors. Human-related causes include antimicrobial overuse and misuse in medicine, antibiotic-containing cosmetics and biocides utilization, and inadequate sanitation and hygiene in public settings. Prophylactic and therapeutic antimicrobial misuse and overuse, using antimicrobials as feed additives, microbes resistant to antibiotics and resistance genes in animal excreta, and antimicrobial residue found in animal-origin food and excreta are animals related contributive factors for the antibiotic resistance emergence and spread. Environmental factors including naturally existing resistance genes, improper disposal of unused antimicrobials, contamination from waste in public settings, animal farms, and pharmaceutical industries, and the use of agricultural and sanitation chemicals facilitatet its emergence and spread. Wildlife has a plausible role in the antimicrobial resistance spread. Adopting a one-health approach involving using antimicrobials properly in animals and humans, improving sanitation in public spaces and farms, and implementing coordinated governmental regulations is crucial for combating antimicrobial resistance. Collaborative and cooperative involvement of stakeholders in public, veterinary and ecological health sectors is foremost to circumvent the problem effectively.
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