Characteristics of type 1 and 2 CNV in exudative AMD in OCT-Angiography

Farecki, Marie-Louise; Gutfleisch, Matthias; Faatz, Henrik; Rothaus, Kai; Heimes, B.; Spital, Georg; Lommatzsch, Albrecht; Pauleikhoff, Daniel

doi:10.1007/s00417-017-3588-y

Cited by 77 publications

(50 citation statements)

References 25 publications

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“…In einer eigenen Patientenkohorte ließen sich Typ-1-CNV am häufigsten von den umgebenden Blutgefäßen auf Höhe der mittleren Aderhaut (84,6 %) und der Choriokapillaris (92,2 %) darstellen [26]. Auf dieser Ebene, unterhalb des RPEs, ist nicht in erster Linie von Segmentierungsartefakten auszugehen.…”

Section: Exsudative Amd In Der Oct-angiografieunclassified

“…Als Ursache sind hier neben Lasermodalitäten und der Geschwindigkeit der Scans auch die höhere Wellenlänge der Swept-Source-OCT-A denkbar [27,28]. In unserem Patientenkollektiv zeigten Typ-1-CNV auf Höhe der Aderhaut mit 4,5 mm 2 (± 3,14 mm 2 ) die größte Ausdehnung und wiesen eine Größenabnahme in Richtung der äußeren Netzhautschicht auf [26].…”

Section: Exsudative Amd In Der Oct-angiografieunclassified

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Exsudative AMD in der OCT-Angiografie

Farecki

Gutfleisch

Faatz

et al. 2017

Klin Monatsbl Augenheilkd

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OCT angiography provides a combination of vascular and structural information. In contrast to conventional fluorescein angiography, there is no need for dye injection to give an image of choroidal neovascularisation. Although there is currently no classification of OCT angiography, different neovascular patterns can be observed, with criteria for activity. In the future, OCT angiography may help us to understand pathophysiological mechanisms and to develop therapeutic strategies.

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Section: Exsudative Amd In Der Oct-angiografieunclassified

Exsudative AMD in der OCT-Angiografie

Farecki

Gutfleisch

Faatz

et al. 2017

Klin Monatsbl Augenheilkd

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“…Type I CNV appears on the choriocapillaris layer penetrating the Brusch's membrane and below the RPE [62]. This CNV appears as a minimal demarcated vascularization arising from choroid, choriocapillaris, and RPE with no evidence of neovascularization in outer retina [63]. A retrospective case series by Roisman et al found that OCTA exhibits more detailed images in detecting CNV compared to FFA and ICGA in asymptomatic ARMD patients [64].…”

Section: The New Advance In Retinal Imaging For Age-related Macular Dmentioning

confidence: 99%

“…Andi Arus Victor Department of Ophthalmology, Faculty of Medicine, Cipto Mangunkusumo National General Hospital, Universitas Indonesia, Jakarta, Indonesia *Address all correspondence to: arvimadao@yahoo.com at the choroid, choriocapillaris, RPE, and extending to outer retina [63]. Lastly, the appearance of RAP or type III CNV is hyperreflective cluster situated in outer retinal layer with interconnecting vessel with the inner retinal circulation (Figure 7) [66].…”

Section: Author Detailsmentioning

confidence: 99%

The Role of Imaging in Age-Related Macular Degeneration

Victor¹

2020

Visual Impairment and Blindness - What We Know and What We Have to Know

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Age-related macular degeneration (ARMD) is the leading cause of blindness affecting adults. The disease alters the macula, center of the retina, responsible for the keenest vision. Although ARMD is part of the aging process, the exact pathophysiology is still unknown. The evidence suggests that oxidative stress, lipofuscin accumulation, drusen accumulation, chronic inflammation, choroidal neovascularization, and mutations of the complement contribute to the development of ARMD. Early recognition and prompt treatment halt the progression of the disease. The advanced technology in imaging modalities provides comprehensive and complete management at the earliest stage of ARMD.Keywords: macular degeneration, age-related macular degeneration, imaging, fundus photography, fundus autofluorescence, fundus fluorescence angiography, indocyanine green angiography, optical coherence tomography, optical coherence tomography angiography Visual Impairment and Blindness -What We Know and What We Have to Know 2 2. An overview of age-related macular degeneration Age-related macular degeneration is commonly classified based on its characteristics into dry (nonexudative) ARMD and wet (exudative) ARMD [5,7]. Meanwhile, according the natural course of the disease, it categorizes into early, intermediate, and advanced ARMD [6,7]. Dry ARMD represents approximately 90% of diagnosed ARMD cases [5,7]. This type is distinguished by the present drusen accumulation, the absence of choroid neovascularization, and retinal pigment epithelium (RPE) atrophy [8]. The hallmark of wet ARMD is the development of choroidal neovascularization, and this fragile new blood vessel tends to leak forming exudates [9]. It counts for 10% of ARMD cases and has been linked with rapid deterioration toward blindness [7].Beyond aging process, smoking and ethnicity are the only consistent risk factors related with ARMD documented in studies. A cohort study of 65 years old or older patients found smoking doubles the risk of having ARMD in 5 years compared to nonsmokers [10]. The exact underlying pathophysiology of ARMD is still unknown. Several theories are hypothesized to be the fundamental factors behind ARMD. These include lipofuscin accumulation, drusen accumulation, chronic inflammation, oxidative stress, reduction of antioxidant, mutation of complements, and choroidal neovascularization [10,11]. The new blood vessels are fragile and generate complications to the surrounding structure causing hemorrhages, exudate, RPE and/or retinal detachment, and scar, hence the progression into the end-stage ARMD, which is exudative ARMD [5,6,9,12].The identification of ARMD in patients is a crucial aspect in delivering early treatment. Elder patients especially those aged above 40 years are more susceptible to develop ARMD. According to the American Academy of Ophthalmology, it is suggested that individuals aged 40 years and above should be screened for the possible ARMD. Binocular slit-lamp examination with three mirror lens or condensing lens is also needed to disclose drus...

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“…Perhaps the most immediate clinical application of OCT‐A is in the detection and management of choroidal neovascularisation (Figure ). Based on the anatomical location of new vessel growth – either below the retinal pigmented epithelium layer (type 1 or occult choroidal neovascularisation); between the retinal pigmented epithelium layer and the retina (type 2 or classic choroidal neovascularisation); or starting within the retina and anastomosing with the choroidal circulation (type 3 or retinal angiomatous proliferation) – all subtypes of choroidal neovascularisation can be detected with OCT‐A …”

Section: Applications In Retinal Diseasementioning

confidence: 99%

Future clinical applicability of optical coherence tomography angiography

Chua

Tan

Ang

et al. 2019

Clinical and Experimental Optometry

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Optical coherence tomography angiography (OCT-A) is an emerging technology that allows for the non-invasive imaging of the ocular microvasculature. Despite the wealth of observations and numerous research studies illustrating the potential clinical uses of OCT-A, this technique is currently rarely used in routine clinical settings. In this review, technical and clinical aspects of OCT-A imaging are discussed, and the future clinical potential of OCT-A is considered. An understanding of the basic principles and limitations of OCT-A technology will better inform clinicians of its future potential in the diagnosis and management of ocular diseases.

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Characteristics of type 1 and 2 CNV in exudative AMD in OCT-Angiography

Cited by 77 publications

References 25 publications

Exsudative AMD in der OCT-Angiografie

Exsudative AMD in der OCT-Angiografie

The Role of Imaging in Age-Related Macular Degeneration

Future clinical applicability of optical coherence tomography angiography

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