Identifying intracranial lesions in patients with maxillofacial injuries is crucial to improving survival. The purpose of this study was to compile a predictive index of the occurrence of intracranial lesions based on age, location of trauma, and cause of injury in maxillofacial trauma patients. An analytical observational study with a retrospective cohort design. Bivariable analysis and Multivariate analysis using SPSS IBM 26. The value of p<0.005 is significant. There were 81 subjects with maxillofacial trauma with intracranial lesions. Most of the samples were 25 years old (71.6%). Meanwhile, based on the location of the fracture, most of the subjects suffered from Le Fort I, Le Fort II, or a combination of both (70.4%). Only 12.3% of subjects had Le Fort III fractures (with or without Le Fort I or II fractures), and only 17. 3% had concurrent Le Fort II and III fractures. As for 80.2% of the subjects suffered injuries caused by traffic accidents. Intracranial lesions were found in 59.3% of subjects with predominant EDH (21%). Age 25 years increased the risk of intracranial lesions with adjusted OR 19.77 (95% CI 3.77–103.67). Le Fort II & III fractures adjusted OR of 52.68 (95%CI 2.50–112.188). Traffic accident an adjusted OR of 16.75 (95%CI 2.83–99.29). There was a significant and independent relationship between age 25 years, location of Le Fort II & III fractures, and traffic accidents as a cause of injury with intracranial lesions in patients with maxillofacial fractures.