Characteristics of the Skin Microbiome in Selected Dermatological Conditions: A Narrative Review

Olunoiki, Esther; Rehner, Jacqueline; Bischoff, Markus; Koshel, Elena I.; Vogt, Thomas; Reichrath, Jörg; Becker, Sören L.

doi:10.3390/life12091420

Cited by 6 publications

(1 citation statement)

References 129 publications

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“…Although skin microbiome knowledge has advanced in recent years for skin diseases, 81 little is known of the microbiome in dry and sensitive skin conditions. However, the impact of exogenous factors on the skin microbiome is established.…”

Section: Introductionmentioning

confidence: 99%

Epidermal barrier function in dry, flaky and sensitive skin: A narrative review

Fluhr,

Moore,

Lane

et al. 2023

Acad Dermatol Venereol

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The stratum corneum (SC)—the outermost layer of the epidermis—is the principal permeability and protective barrier of the skin. Different components of the SC, including corneocytes, natural moisturizing factor, a variety of enzymes and their inhibitors, antimicrobial peptides and lipids, work interactively to maintain barrier function. The main barrier properties of the SC are the limitation of water loss and the prevention of infection and contact with potentially harmful exogenous factors. Although the SC functions consistently as a protective barrier throughout the body, variations in functions and morphology occur across body sites with age and skin type. Healthy SC function also depends on the interplay between the chemosensory barrier, the skin's microbiome and the innate immune system. Dysregulation of SC barrier function can lead to the development of skin disorders, such as dry, flaky or sensitive skin, but the complete underlying pathophysiology of these are not fully understood. This review provides insight into the current literature and emerging themes related to epidermal barrier changes that occur in the context of dry, flaky and sensitive skin. Additional studies are needed to further elucidate the underlying aetiology of dry, flaky and sensitive skin and to provide tailored treatment.

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Section: Introductionmentioning

confidence: 99%

Epidermal barrier function in dry, flaky and sensitive skin: A narrative review

Fluhr,

Moore,

Lane

et al. 2023

Acad Dermatol Venereol

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Bio‐Inspired Antioxidant Heparin‐Mimetic Peptide Hydrogel for Radiation‐Induced Skin Injury Repair

Hao

Guo

et al. 2023

Adv Healthcare Materials

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Radiotherapy is one of the most important means of cancer treatment, however, radiation can also cause adverse reactions and even serious injuries to the skin. Radiation‐induced excess reactive oxygen species (ROS) production and inflammatory infiltration make skin wounds difficult to heal compared to normal skin injuries. Herein, an antioxidant heparin‐mimetic peptide hydrogel (K16, KYKYEYEYAGEGDSS‐4Sa) is designed for radiation‐induced skin injury (RISI) repair. First, the K16 peptide can self‐assemble into a hydrogel with a 3D mesh‐like porous nanofiber structure, which can provide certain physical support for skin repair like extracellular matrix (ECM). Then, K16 hydrogel not only scavenges ROS and prevents radiation damage to cellular DNA, but also promotes cell proliferation, migration, and angiogenesis. Meanwhile, 4‐sulfobenzoic acid (4Sa) modified at the N‐terminal end of the K16 peptide can adsorb inflammatory cytokines, thus acting to eliminate inflammation at the wound site. In vivo experiments showed that K16 hydrogel can inhibit early wound degradation, reduce inflammatory infiltration, and promote angiogenesis and collagen deposition, thus promoting wound healing. Therefore, the K16 hydrogel designed in this study has good potential for application in the field of radiation‐induced skin injury repair.

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