Characteristics of the purified uteroglobin-like protein from rabbit lung

Beato, Miguel; Beier, Henning M.

doi:10.1530/jrf.0.0530305

Cited by 33 publications

(4 citation statements)

References 27 publications

(42 reference statements)

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“…Later, it turned out that the same protein is also expressed in other tissues in significant amounts. Soon after the discovery of uteroglobin, for example, a uteroglobin‐like antigen or protein 1 was detected in the rabbit lung 2 and male genital tract. 3 By comparing numerous biochemical and physicochemical parameters, purified uteroglobin‐like protein from rabbit lung and uteroglobin from the uterus were shown to be identical.…”

Section: Compilation Of Trivial Names Assigned To Members Of the Secrmentioning

confidence: 99%

“…3 By comparing numerous biochemical and physicochemical parameters, purified uteroglobin‐like protein from rabbit lung and uteroglobin from the uterus were shown to be identical. 1 These early results were rediscovered ten years later when a Clara cell secretory protein (CCSP) was described in the rabbit lung, 4 which was again shown to be identical to uteroglobin. 5 From then on, the name CCSP and related versions thereof were often used by scientists investigating the mouse, rat, and human lung (Table 1).…”

Section: Compilation Of Trivial Names Assigned To Members Of the Secrmentioning

confidence: 99%

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Uteroglobin/Clara Cell 10‐kDa Family of Proteins: Nomenclature Committee Report

Klug

Beier

Bernard

et al. 2000

Annals of the New York Academy of Sciences

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133

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Section: Compilation Of Trivial Names Assigned To Members Of the Secrmentioning

confidence: 99%

Section: Compilation Of Trivial Names Assigned To Members Of the Secrmentioning

confidence: 99%

Uteroglobin/Clara Cell 10‐kDa Family of Proteins: Nomenclature Committee Report

Klug

Beier

Bernard

et al. 2000

Annals of the New York Academy of Sciences

Self Cite

133

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“…A uteroglobin-like protein was also found in other tissues of the rabbit, particularly in the lung (Noske & Feigelson, 1976). On the basis of immunological and chemical studies (Beato & Beier, 1978;Torkkeli et al, 1978), it appears that uterine and lung Abbreviations used: poly(A)+ mRNA, poly(A)-containing mRNA; SDS, sodium dodecyl sulphate. * To whom reprint requests should be addressed.…”

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confidence: 99%

Glucocorticoid and developmental regulation of uteroglobin synthesis in rabbit lung

Lombardero¹,

Nieto²

1981

Biochemical Journal

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The synthesis of uteroglobin in rabbit lung was studied after the administration of glucocorticoids to intact adult animals as well as during the late stages of rabbit development. The synthesis of uteroglobin was compared with levels of translatable uteroglobin mRNA in the lung. Uteroglobin synthesis was determined both by incorporation of [25S]methionine into the protein by lung explants incubated in vitro and by radioimmunoassay measurements of uteroglobin concentration in lung. Lung poly(A)-containing mRNA, isolated by oligo(dT)--cellulose chromatography, was translated in cell-free systems and the activity of uteroglobin mRNA was determined after immunoprecipitation. Dexamethasone administration increased about 2-fold the synthesis of lung uteroglobin compared with the controls. The effect of cortisol was more moderate. Both glucocorticoids did not affect the degradation rate of lung uteroglobin, but produced increases in the translatable levels of uteroglobin mRNA parallel to those observed for uteroglobin synthesis. During the late stages of rabbit development, both the synthesis of lung uteroglobin and the translatable levels of its mRNA increase in parallel about 12-fold in a biphasic fashion. A first increase occurred between 2 days before and 2 days after birth. Starting at 5 days of age, there was a second increase in both parameters, which at 12 days of age reached values close to those observed in adult rabbits. Our results suggest that the rate of lung uteroglobin synthesis could be mainly determined by the translatable levels of its mRNA.

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“…[21][22][23][24] The structure of this protein is similar to that of a previously described protein secreted by rabbit endometrium called uteroglobin. [34][35][36][37][38][39][40] The protein has been referred to by various names in the literature. In the initial description of the protein, related to its appearance in the rabbit reproductive tract around the time of implantation, it was called blastokinin.…”

Section: Cc10 Proteinmentioning

confidence: 99%

Clara Cell Proteins

Singh

Katyal

2000

Annals of the New York Academy of Sciences

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Clara cells are nonciliated, nonmucous, secretory cells of the pulmonary airways. These cells are known to secrete a variety of proteins, including Clara cell 10‐kDa protein/uteroglobin. This protein consists of a homodimer of 70–77 amino acid polypeptides arranged in antiparallel fashion. In vitro testing suggests that the protein suppresses inflammation. The physiologic role of the protein remains to be determined.

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Characteristics of the purified uteroglobin-like protein from rabbit lung

Cited by 33 publications

References 27 publications

Uteroglobin/Clara Cell 10‐kDa Family of Proteins: Nomenclature Committee Report

Uteroglobin/Clara Cell 10‐kDa Family of Proteins: Nomenclature Committee Report

Glucocorticoid and developmental regulation of uteroglobin synthesis in rabbit lung

Clara Cell Proteins

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