Clara Cell Proteins

Singh, Gurmukh; Katyal, Sikandar L.

doi:10.1111/j.1749-6632.2000.tb05518.x

Cited by 95 publications

(95 citation statements)

References 78 publications

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“…CC10 is constitutively expressed in the epithelial cells of organs that directly communicate with the external environment, including the nose, bronchi and lungs (7)(8)(9). Furthermore, CC10 is an important mediator of inflammatory and allergic responses, as well as responses to malignant tumors of the respiratory system (10).…”

Section: Introductionmentioning

confidence: 99%

“…Clara cell 10-kDa protein (CC10), also known as uteroglobin, is a steroid-inducible member of the secretoglobin family that serves an important role in the regulation of anti-inflammatory and immunomodulatory activities (7,8). CC10 is constitutively expressed in the epithelial cells of organs that directly communicate with the external environment, including the nose, bronchi and lungs (7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

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Expression of Clara cell 10-kDa protein and trefoil factor family 1 in patients with chronic rhinosinusitis and nasal polyps

Wang

2018

Exp Ther Med

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Abstract. The current study measured the expression of Clara cell 10-kDa protein (CC10) and trefoil factor family 1 (TFF1) in the sinus mucosa of patients exhibiting chronic rhinosinusitis (CRS) and nasal polyps (NP). CC10 and TFF1 expression in the sinus mucosa of the control group and patients with CRS and NP was determined using reverse transcription-quantitative polymerase chain reaction (RT-qPCR), western blotting and immunohistochemistry. The correlation between CC10 and TFF1 expression was further analyzed using Spearman's correlation analysis. The expression of TFF1 was significantly increased in the sinus mucosa of patients with CRS and NP, whereas CC10 expression was significantly decreased compared with controls. Spearman's correlation analysis identified a negative correlation between CC10 and TFF1 expression in the sinus mucosa of patients with CRS and NP. The results of immunohistochemistry and RT-qPCR were consistent with each other. Hematoxylin and eosin staining revealed notable lesions in the mucous membranes, goblet cells and cilia of sinus mucosa samples from patients with CRS and NP. The negative correlation between CC10 and TFF1 expression during the progression of CRS and NP suggest that CC10 and TFF1 may serve important roles in its pathogenesis.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Expression of Clara cell 10-kDa protein and trefoil factor family 1 in patients with chronic rhinosinusitis and nasal polyps

Wang

2018

Exp Ther Med

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“…Therefore, it is likely that some genes constitutively expressed in the airways maintain homeostasis in the mammalian respiratory system, which suppresses the allergen-mediated inflammatory response. An example of such a gene is uteroglobin (UG) (59), also known as CC10 (60). UG is a secretory protein that manifests immunomodulatory, anti-chemotactic, and anti-inflammatory properties (reviewed in Ref.…”

Section: Gene Expression In Allergic Airway Inflammation and Allergicmentioning

confidence: 99%

Allergic Asthma: Influence of Genetic and Environmental Factors

Mukherjee

Zhang

2011

Journal of Biological Chemistry

122

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Allergic asthma is a chronic airway inflammatory disease in which exposure to allergens causes intermittent attacks of breathlessness, airway hyper-reactivity, wheezing, and coughing. Allergic asthma has been called a "syndrome" resulting from a complex interplay between genetic and environmental factors. Worldwide, >300 million individuals are affected by this disease, and in the United States alone, it is estimated that >35 million people, mostly children, suffer from asthma. Although animal models, linkage analyses, and genome-wide association studies have identified numerous candidate genes, a solid definition of allergic asthma has not yet emerged; however, such studies have contributed to our understanding of the multiple pathways to this syndrome. In contrast with animal models, in which T-helper 2 (T H 2) cell response is the dominant feature, in human asthma, an initial exposure to allergen results in T H 2 cell-dependent stimulation of the immune response that mediates the production of IgE and cytokines. Re-exposure to allergen then activates mast cells, which release mediators such as histamines and leukotrienes that recruit other cells, including T H 2 cells, which mediate the inflammatory response in the lungs. In this minireview, we discuss the current understanding of how associated genetic and environmental factors increase the complexity of allergic asthma and the challenges allergic asthma poses for the development of novel approaches to effective treatment and prevention.

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“…141 Amniotic levels of CC10 during mid-trimester were significantly higher in women who had preterm premature rupture of membranes compared with women who did not, and this elevation of CC10 could be in response to a proinflammatory event. 106 Although CC10 is the most studied secretion of Clara cells, Clara cells also produce SP-A and SP-D. 100,128 Clara cell cytochrome P450 enzymes such as CYP1A1 and CYP1A2 detoxify inhaled compounds and compounds entering the lung hematogenously. This is beneficial for some toxins; however, a toxic metabolite, 3-methylindololam-ine, is a toxic metabolite formed by Clara cell metabolism of 3-methyl indole.…”

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confidence: 99%

“…15 Clara cells are nonciliated bronchiolar epithelial cells with multiple roles in the airways. Clara cells biometabolize xenobiotics, 19 secrete immunomodulatory substances, 128 and act as progenitor cells. 11 Just as type II pneumocytes serve as a proliferation pool to replace dead and damaged type I pneumocytes, Clara cells act as a progenitor for type II cells, forming a proliferation pool that is vulnerable to exhaustion, especially in neonates, 123,124 but also in chronic smokers (chronic toxin exposure).…”

mentioning

confidence: 99%

The Innate Immune System of the Perinatal Lung and Responses to Respiratory Syncytial Virus Infection

Derscheid

Ackermann

2013

Vet Pathol

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The response of the preterm and newborn lung to airborne pathogens, particles, and other insults is initially dependent on innate immune responses since adaptive responses may not fully mature and require weeks for sufficient responses to antigenic stimuli. Foreign material and microbial agents trigger soluble, cell surface, and cytoplasmic receptors that activate signaling cascades that invoke release of surfactant proteins, defensins, interferons, lactoferrin, oxidative products, and other innate immune substances that have antimicrobial activity, which can also influence adaptive responses. For viral infections such as respiratory syncytial virus (RSV), the pulmonary innate immune responses has an essential role in defense as there are no fully effective vaccines or therapies for RSV infections of humans and reinfections are common. Understanding the innate immune response by the preterm and newborn lung may lead to preventive strategies and more effective therapeutic regimens.

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Clara Cell Proteins

Cited by 95 publications

References 78 publications

Expression of Clara cell 10-kDa protein and trefoil factor family 1 in patients with chronic rhinosinusitis and nasal polyps

Expression of Clara cell 10-kDa protein and trefoil factor family 1 in patients with chronic rhinosinusitis and nasal polyps

Allergic Asthma: Influence of Genetic and Environmental Factors

The Innate Immune System of the Perinatal Lung and Responses to Respiratory Syncytial Virus Infection

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