Characteristics of Synchronous- and Metachronous-Type Multiple Primary Neoplasms: A Study of Hospital-Based Cancer Registry in Turkey

The aim of this study was to determine the clinical features, treatment factors, and prognosis of patients with multiple primary malignant tumors (MPMTs). In total, 161 patients with MPMTs at our hospital (The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China) were analyzed in this study. We found that among 161 patients with MPMTs, 78 (48.4%) patients had synchronous tumors and 83 (51.6%) patients had metachronous tumors. Most clinical and pathological features were similar in both groups. Most patients with MPMTs were men and older patients (>50 years old), and adenocarcinoma was the most frequent pathology type. The most frequent location of all MPMTs was the digestive system. The leading tumor association was between digestive–digestive tumors, also. However, patients with synchronous tumors and MPMTs of the digestive system showed a shorter survival time. In the metachronous cancer group, the median interval time was 60 months, and a short interval time (≤60 months) was associated with a shorter survival time. In addition, survival time was increased in the younger age group (≤50 years old) and in patients who accepted surgery-based comprehensive therapy. However, only interval time (≤60 months) was an independent prognostic factor associated with survival for the metachronous cancer group. Therefore, careful surveillance and follow-up are especially important in these patients.

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“…This allows more patients with cancer to survive long enough to develop multiple primary malignant tumors (MPMTs). [3] …”

Section: Introductionmentioning

confidence: 99%

Clinical analysis and prognosis of synchronous and metachronous multiple primary malignant tumors

Zhang

Shen

et al. 2017

Medicine

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“…Multiple primary tumours can be metachronous orless frequently -synchronous, defined as tumours diagnosed within 2 months. Synchronous other malignant tumour has been reported in 2.2 -2.5% of renal and 2.5% liver cancer patients (Hayat et al, 2007;Kilciksiz et al, 2007). In addition, both hepatocellular carcinoma and renal clear cell carcinoma are uncommon tumours.…”

Section: Discussionmentioning

confidence: 98%

Synchronous Renal and Hepatocellular Carcinomas

Jēkabsone¹,

Bogdanova²,

Āboliņš³

et al. 2014

Acta Chirurgica Latviensis

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SummaryMultiple synchronous primary tumours can cause diagnostic difficulties regarding primary origin versus metastatic spread. Greater awareness of concurrent carcinogenesis is necessary as more frequent occurrence of multiple primary cancers can be expected in future due to the growing tumour burden in the aging world population along with improved treatment efficacy. Here we report a 58-year-old male patient, who was diagnosed with two rare synchronous tumours: hepatocellular carcinoma and renal clear cell carcinoma. Both tumours were radically removed by simultaneous liver and kidney resection. AIM OF THE DEMONSTRATIONThe aim of our report is to show a case of two synchronous malignant tumours in the liver and kidney in order to increase the awareness about multiple primary cancers and the related diagnostic approach. CASE REPORTA 58-year-old male was admitted to a university hospital for surgical treatment of malignant tumour within kidney and liver. Metastatic spread was suspected. By upper laparotomy approach, the liver segments S5 and S6 were resected. Cholecystectomy and right kidney resection was performed simultaneously. The removed liver segment, gall bladder and kidney segment were sent for histological examination. Grossly, the liver segment measured 11.5x12.5x7.0 cm. A grey, relatively well-demarcated, homogeneous lesion was detected within the removed liver tissue 1.0 cm apart from resection line. Multiple tissue sections were submitted for microscopic evaluation and measurements. Microscopically, an invasive hepatocellular carcinoma was found (Figure 1). The tumour displayed trabecular structure and moderate cellular atypia. Although clear cell areas were present, the cytoplasmic fat vacuoles and rich presence of Mallory hyaline were suggestive of hepatocellular origin. The clear cell areas also contained Mallory hyaline. Areas of typical morphology were present as well. Gall bladder was also removed during the course of operation. It measured 9.0x3.7cm; and the thickness of wall was 0.4 cm. Only tiny cholesterol polyps were identified in the mucosa. There were no signs of malignancy within the gall bladder. Kidney segment grossly measured 6.0x5.4x5.5 cm. At grossing, the resection surface was inked by Alcian blue. In the cross section, a tumour mass 3.4x3.7x4.8 cm was observed. The tumour was soft, yellow with extensive haemorrhage and greyish areas. Multiple sections were submitted for microscopic evaluation yielding invasive renal carcinoma, clear cell type. The malignant tumour cells had irregular morphology, clear cytoplasm, dark and round central nuclei and small nucleoli visible at high magnification corresponding to grade II by Fuhrman (Figure 1).Within tumour mass, secondary changes were presentlarge areas of necrosis and haemorrhages. Tumour was surrounded with fibrous pseudocapsule which was focally penetrated by tumour cells spreading to renal parenchyma. There was no evidence of invasion into perirenal or hilar fat, or large blood vessels. By immunohistochemistry, hepatocellular car...

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“…Les CPM représentent environ 5,5 à 8,5 % de tous les cas de cancers décrits dans la littérature [6]. Leur incidence varie, selon les auteurs, de 0,2 à 13,1 % (toutes formes et tous sièges confondus) [7][8][9][10], alors qu'elle représente environ 7,5 % des cancers de la tête et du cou [7].…”

Section: Discussionunclassified

“…Selon Kilciksiz et al [6], les cancers synchrones sont définis par l'apparition d'un second cancer primitif survenant dans les six mois qui suivent la détection du premier cancer, alors que les tumeurs métachrones sont considérées comme celles diagnostiquées à un intervalle de temps de plus de six mois.…”

Section: Discussionunclassified

Carcinome papillaire de la thyroïde associé à deux autres carcinomes primitifs cutanés : approche épidémiologique et physiopathologique - À propos d’un cas

2012

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Characteristics of Synchronous- and Metachronous-Type Multiple Primary Neoplasms: A Study of Hospital-Based Cancer Registry in Turkey

Cited by 25 publications

References 22 publications

Clinical analysis and prognosis of synchronous and metachronous multiple primary malignant tumors

Clinical analysis and prognosis of synchronous and metachronous multiple primary malignant tumors

Synchronous Renal and Hepatocellular Carcinomas

Carcinome papillaire de la thyroïde associé à deux autres carcinomes primitifs cutanés : approche épidémiologique et physiopathologique - À propos d’un cas

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