Characteristics Of Sarcoidosis In Residents And Workers Exposed To World Trade Center (WTC) Dust, Gas And Fumes Presenting For Medical Care

Parsia, Sam; Yee, Herman; Young, Stephanie; Turetz, Meredith L.; Marmor, Michael; Wilkenfeld, Marc; Kazeros, Angeliki; Caplan-Shaw, Caralee; Reibman, Joan

doi:10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a1740

Cited by 3 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Sarcoidosis has been identified in all WTC cohorts (FDNY, general responders other than FDNY, the survivor population and the WTC Registry), the most extensively described being that from FDNY [4,16,23,24,25,26]. In our current FDNY case-control study, we examine genetic characteristics in our cases as compared with our WTC-exposed controls without sarcoidosis.…”

Section: Discussionmentioning

confidence: 99%

Genetic Variants Associated with FDNY WTC-Related Sarcoidosis

Cleven

Zeig‐Owens

et al. 2019

IJERPH

View full text Add to dashboard Cite

Sarcoidosis is a systemic granulomatous disease of unknown etiology. It may develop in response to an exposure or inflammatory trigger in the background of a genetically primed abnormal immune response. Thus, genetic studies are potentially important to our understanding of the pathogenesis of sarcoidosis. We developed a case-control study which explored the genetic variations between firefighters in the Fire Department of the City of New York (FDNY) with World Trade Center (WTC)-related sarcoidosis and those with WTC exposure, but without sarcoidosis. The loci of fifty-one candidate genes related to granuloma formation, inflammation, immune response, and/or sarcoidosis were sequenced at high density in enhancer/promoter, exonic, and 5’ untranslated regions. Seventeen allele variants of human leukocyte antigen (HLA) and non-HLA genes were found to be associated with sarcoidosis, and all were within chromosomes 1 and 6. Our results also suggest an association between extrathoracic involvement and allele variants of HLA and non-HLA genes found not only on chromosomes 1 and 6, but also on chromosomes 16 and 17. We found similarities between genetic variants with WTC-related sarcoidosis and those reported previously in sporadic sarcoidosis cases within the general population. In addition, we identified several allele variants never previously reported in association with sarcoidosis. If confirmed in larger studies with known environmental exposures, these novel findings may provide insight into the gene-environment interactions key to the development of sarcoidosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Genetic Variants Associated with FDNY WTC-Related Sarcoidosis

Cleven

Zeig‐Owens

et al. 2019

IJERPH

View full text Add to dashboard Cite

show abstract

“…Rather than a single disease entity, sarcoidosis may be a constellation of “sarcoidoses,” with a characteristic pattern of organ involvement, depending upon the underlying genotype and triggering exposure. Exposure to the dust and fumes from the destruction of the World Trade Center (WTC) on 11 September 2001 (9/11) has been suggested to be one such trigger with sarcoidosis diagnoses described in WTC-exposed members of the Fire Department of the City of New York (FDNY), those involved in rescue and recovery efforts (responders), and community members (“survivors”) with WTC dust exposure [2,3,4,5,6,7]. Increased incidence rates have been reported for the firefighters and responders [2,3,6].…”

Section: Introductionmentioning

confidence: 99%

Clinical Evaluation of Sarcoidosis in Community Members with World Trade Center Dust Exposure

Hena

Murphy

Zhang

et al. 2019

IJERPH

View full text Add to dashboard Cite

Background: Sarcoidosis is a granulomatous disease involving intrathoracic and extrathoracic organs. Genetic and environmental factors, such as exposure to World-Trade Center (WTC) dust after 9/11, may play a role in clinical presentation. Characterization of sarcoidosis in community members with exposure to the WTC dust can provide further insight into the relationship between environmental exposure and sarcoidosis. Methods: Patients with documented sarcoidosis were identified in the WTC Environmental Health Center (EHC), a treatment program for community members. Demographic and clinical data were collected from standardized questionnaires and chart review. Organ involvement was assessed with a standard instrument. Results: Among patients in the WTC EHC, 87 were identified with sarcoidosis after 9/11. Sarcoidosis cases were more likely African-American, local workers, and had more respiratory symptoms, compared with non-sarcoidosis WTC EHC patients. Many (46%) had ≥ Scadding stage 3 on chest imaging, and had reduced lung function measures. Extrathoracic involvement was identified in 33/87 (38%) with a diversity of organs involved. Conclusions: WTC-exposed sarcoidosis in community members is often characterized by severe pulmonary disease and a high rate of diverse extrathoracic involvement. Further analysis is required to characterize the course of disease progression or resolution.

show abstract

“…An elevated incidence of sarcoidosis was described among members of the Fire Department of New York (FDNY) between 1985 and 1998, 11 and a further increase in sarcoidosis-like granulomatous pulmonary disease (SLGPD) was observed during the first 5 years after the September 11, 2001, World Trade Center (WTC) disaster (9/11) among FDNY members who had performed postdisaster rescue or recovery work. 12 Sarcoidosislike granulomatous pulmonary disease was also described among 38 rescue or recovery workers enrolled in the WTC Medical Monitoring and Treatment Program, 13 and among 23 lower-Manhattan area residents, workers, and cleanup workers receiving medical care at Bellevue Hospital, 14 as well as in smaller case reports. 15 These reports suggest a potential relationship between sarcoidosis and 9/11-related exposures; however, there are only limited epidemiologic data on the relationship between specific 9/11-related exposures and sarcoidosis among rescue or recovery workers, and even less for other exposed populations.…”

mentioning

confidence: 98%